Organic electrosynthesis method of phenothiazine/phenoxazine compound

Abstract

The invention discloses an organic electrosynthesis method of a phenothiazine / phenoxazine compound. The organic electrosynthesis method adopts an organic electrosynthesis means for a compound shown ina formula I and a compound shown in a formula II to prepare the phenothiazine / phenoxazine compound. The organic electrosynthesis method disclosed by the invention has the beneficial effects that a target product shown in a formula III can be obtained by directly activating C-H without need of expensive halogenated raw materials and additional reduction and substitution processes, so that the process flow is obviously shortened, the operation is simplified, the preparation efficiency is improved, and the production cost is reduced; the reaction condition is simple, mild and environmentally friendly, the atom economy is high, the adaptation range of a reaction substrate is wide, and the yield of a target product is high.

Description

technical field [0001] The application belongs to the technical field of organic synthesis, and in particular relates to an electrochemical synthesis method of phenothiazine / phenoxazine compounds. Background technique [0002] Phenothiazine compounds have been found to have a series of pharmacological activities from the beginning of their synthesis, and their traditional medicinal properties are antihistamine and mental stability. There are a large number of applications in both. And, phenothiazine structures are also widely used in the treatment of Parkinson's disease, malaria, tumors and other diseases (for example, see (1) "Synthesis and application of phenothiazine and its derivatives", Jiang Yuntao et al., "Dye and Staining", Vol. 47, No. 3, Pages 35-42, June 2010; (2) "Research on the Potential Anti-tumor Mechanism of Phenothiazines", Qi Lu et al., "Science in China: Life Sciences", Vol. 43, No. 11, pp. 939-946, 2013; et al.). At present, the research hotspots on p...

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Problems solved by technology

However, such synthetic methods involve defects such as high temperature, expensive halogenation reaction substrates, and multi-step reaction operations, resulting in low efficiency and high cost.

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