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Medicine for treating central diabetes insipidus and application thereof

A diabetes insipidus, central technology, applied in the field of medicine, can solve problems such as side effects, multiple adverse reactions and side effects, and high price

Active Publication Date: 2018-11-23
郑士平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few therapeutic drugs available for clinical selection, and antidiuretic hormone and its analogues are polypeptide drugs, which are expensive; carbamazepine, hydrochlorothiazide, chlorpropamide, etc. have many adverse reactions and side effects
Some even have more serious side effects

Method used

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  • Medicine for treating central diabetes insipidus and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Oral tablets for the treatment of central diabetes insipidus

[0024] The amount of raw materials and pharmaceutical excipients:

[0025] Compound (I) 25g

[0026] 400g lactose

[0027] Pregelatinized starch 360g

[0028] Microcrystalline cellulose 100g

[0029] Hydroxypropyl cellulose 100g

[0030] Magnesium stearate 10g

[0031] Water 2000g

[0032] Preparation:

[0033] A: The prescription amount of compound (I), lactose, pregelatinized starch, and microcrystalline cellulose are separately crushed, passed through a 100-mesh sieve, and mixed to obtain a powder mixture;

[0034] B. Dissolve the prescription amount of hydroxypropyl cellulose in the prescription amount of water to make a solution, add the powder mixture obtained in step A to the soft material, pass through an 18-mesh sieve, dry at 60°C, sizing on a 16-mesh sieve, and then add magnesium stearate and mix well Press the tablet into 10,000 tablets.

Embodiment 2

[0035] Example 2 Oral tablets for the treatment of central diabetes insipidus

[0036] The amount of raw materials and pharmaceutical excipients:

[0037] Compound (I) 25g

[0038] Indapamide 20g

[0039] 400g lactose

[0040] Pregelatinized starch 360g

[0041] Microcrystalline cellulose 100g

[0042] Hydroxypropyl cellulose 100g

[0043] Magnesium stearate 10g

[0044] Water 2000g

[0045] Preparation:

[0046] A: The prescription amount of compound (I), indapamide, lactose, pregelatinized starch, and microcrystalline cellulose are respectively crushed, passed through a 100-mesh sieve, and mixed to obtain a powder mixture;

[0047] B. Dissolve the prescription amount of hydroxypropyl cellulose in the prescription amount of water to make a solution, add the powder mixture obtained in step A to the soft material, pass through an 18-mesh sieve, dry at 60°C, sizing on a 16-mesh sieve, and then add magnesium stearate and mix well Press the tablet into 10,000 tablets.

Embodiment 3

[0048] Example 3 Oral tablets for the treatment of central diabetes insipidus

[0049] The amount of raw materials and pharmaceutical excipients:

[0050] Compound (I) 25g

[0051] Indapamide 15g

[0052] 400g lactose

[0053] Pregelatinized starch 360g

[0054] Microcrystalline cellulose 100g

[0055] Hydroxypropyl cellulose 100g

[0056] Magnesium stearate 10g

[0057] Water 2000g

[0058] Preparation:

[0059] A: The prescription amount of compound (I), indapamide, lactose, pregelatinized starch, and microcrystalline cellulose are respectively crushed, passed through a 100-mesh sieve, and mixed to obtain a powder mixture;

[0060] B. Dissolve the prescription amount of hydroxypropyl cellulose in the prescription amount of water to make a solution, add the powder mixture obtained in step A to the soft material, pass through an 18-mesh sieve, dry at 60°C, sizing on a 16-mesh sieve, and then add magnesium stearate and mix well Press the tablet into 10,000 tablets.

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Abstract

The invention belongs to the field of medicines, and particularly relates to a medicine for treating central diabetes insipidus and application thereof. The medicine for treating central diabetes insipidus comprises a compound shown in a formula (I) or a formula (II), and further comprises indapamide. The compound shown in the formula (I) or the formula (II) has good treatment function on the central diabetes insipidus, and can reach better treatment effect by combining with the indapamide; the safety is good. The medicine is preferably an oral tablet; the medical auxilari materials preferablycomprise lactose, pregelatinized starch, fine cellulose, hydroxypropyl cellulose and magnesium stearate.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to a medicine for treating central diabetes insipidus and its use. Background technique [0002] Central diabetes insipidus (central diabetes insipidus) is a decrease or lack of antidiuretic hormone, which affects the reabsorption of water by the distal convoluted tubules and collecting ducts of the kidney, resulting in polyuria, polydipsia, low specific gravity and low osmolality. As the main feature of urinary system diseases. According to its cause, the disease is an endocrine disease. The disease and diabetes have similar urinary system symptoms, such as polydipsia, polyuria, etc., but the pathological mechanisms of the two are completely different, so the treatment methods are also different. In recent years, the incidence of the disease has shown an upward trend, and it is more common in children and the elderly. [0003] At present, the clinical treatment of central diabetes in...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/36A61K47/38A61K47/26A61K31/404A61K31/437A61P7/12
CPCA61K9/2018A61K9/2054A61K9/2059A61K31/404A61K31/437A61P7/12A61K2300/00
Inventor 郑士平宋秀艳张玉清
Owner 郑士平
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