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Buccal tablets containing cefalexin

A technology of cephalexin and buccal tablets, which is applied in the field of buccal tablets containing cephalexin, can solve problems such as poor taste, unsustainable drug effectiveness, and uneven blood drug concentration, achieving remarkable effects, stable and long-lasting curative effect, Better dispersion effect

Inactive Publication Date: 2018-11-23
SICHUAN XINGZHI ZHIHUI INTPROP OPERATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the buccal preparations in the prior art have a poor mouthfeel when administered, and after administration, the blood drug concentration of the drug in the lesion is not uniform, and there is a situation of an administration peak and trough, resulting in the drug being effective. sex doesn't last

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A buccal tablet containing cephalexin, by weight percentage, comprising:

[0031] 1-4 servings of cephalexin;

[0032] 1-3 parts of microcrystalline cellulose;

[0033] 16-20 servings of maltitol;

[0034] 2-4 copies of beta-cyclodextrin;

[0035] Hydrogenated vegetable oil 1-3 parts.

[0036] In this embodiment, cephalexin is preferably 3 parts; microcrystalline cellulose is preferably 3 parts; maltitol is preferably 18 parts; beta-cyclodextrin is preferably 3 parts; hydrogenated vegetable oil is preferably 2 parts.

[0037] The preparation technology of above-mentioned cephalexin buccal tablet is as follows:

[0038] First, mix cephalexin and hydrogenated vegetable oil uniformly according to the proportion, then add microcrystalline cellulose and mix well to make mixture 1;

[0039] Secondly, the maltitol and beta cyclodextrin are mixed and heated to make a molten state, and then the mixture is added and mixed evenly;

[0040] Finally, after cooling and solidifi...

Embodiment 2

[0043] The difference between this embodiment and Embodiment 1 is that the specific composition ratio is optimized in this embodiment, and the specific settings are as follows:

[0044] In this embodiment, cephalexin is preferably 4 parts; microcrystalline cellulose is preferably 2 parts; maltitol is preferably 20 parts; beta-cyclodextrin is preferably 2 parts; hydrogenated vegetable oil is preferably 3 parts.

[0045] The buccal tablets prepared in this example were used to conduct a release test, and the results showed that the release was 7% at 0 min, 7% at 3 min, and 8% at 10 min. The dissolution rate is very uniform and the effect is remarkable.

Embodiment 3

[0047] This example is a comparative example, and the buccal tablet in this example includes: 4 parts of cephalexin; 20 parts of maltitol; and 2 parts of beta-cyclodextrin.

[0048] The buccal tablet prepared in this example was used to conduct a release test, and the results showed that the release was 6% at 0 min, 20% at 3 min, and 3% at 10 min.

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PUM

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Abstract

The invention discloses buccal tablets containing cefalexin, aiming at solving the problems in the prior art that the mouthfeel is relatively poor when a buccal preparation is administrated, the plasma drug concentration of a drug on a lesion part is not uniform and the effectiveness of the drug is not lasting. The buccal tablets are prepared from the following components in percentage by weight:1 to 4 parts of the cefalexin, 1 to 3 parts of microcrystalline cellulose, 16 to 20 parts of maltitol, 2 to 4 parts of beta-cyclodextrin and 1 to 3 parts of hydrogenated vegetable oil. According to the buccal tablets disclosed by the invention, a relatively good mouthfeel can be effectively realized and the drug effect can be alleviated better; the drug effect is uniformly released in a mouth holding process and the curative effect is more stable and lasting.

Description

technical field [0001] The invention relates to a buccal tablet, in particular to a buccal tablet containing cephalexin. Background technique [0002] Pharyngitis is the most common disease that plagues modern people's lives. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, which is often a part of upper respiratory tract infection. Clinically, it is divided into acute and chronic. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be confined to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections are dominated by gram-positive cocci such as streptococcus, staphylococcus and pneumococcus. Among them, group A group B streptococcus is the most serious cause. Bacteria or toxins enter the blood and can cause purulent lesi...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/545A61K47/38A61K47/40A61K47/44A61K47/26A61P11/04A61P31/04
CPCA61K31/545A61K9/0056A61K9/2013A61K9/2018A61K9/205A61K9/2054A61P11/04A61P31/04
Inventor 周豪
Owner SICHUAN XINGZHI ZHIHUI INTPROP OPERATION CO LTD
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