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A microneedle patch for intelligently regulating blood sugar and its preparation method

An intelligent adjustment and micro-needle sticking technology, applied in the field of biomedicine, can solve the problems of inability to achieve glucose levels, inconvenience and pain of patients, and achieve the effect of good skin piercing, pain relief, and protection of activity.

Active Publication Date: 2020-08-07
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional blood sugar detection needs to prick the finger to draw blood, repeated needle pricking blood
This method of blood sugar testing and drug injection not only brings inconvenience and pain to patients, but also requires long-term compliance
More importantly, the conventional treatment without direct coupling of glucose sensing and drug therapy cannot achieve strict regulation of the patient's glucose level.

Method used

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  • A microneedle patch for intelligently regulating blood sugar and its preparation method
  • A microneedle patch for intelligently regulating blood sugar and its preparation method
  • A microneedle patch for intelligently regulating blood sugar and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of the medicine of embodiment 1 intelligent regulation blood sugar

[0029] (1) According to the method described in the applicant's previous patent application "Gold Nanocluster Particles for Intelligently Released Insulin to Regulate Blood Sugar and Its Preparation Method" (Application No. 201810075085.8, Publication No. CN 108079282 A) to prepare intelligently released insulin to regulate blood sugar Gold nanocluster particles (GNC-FPBA-Insulin or GNC-PBA-Insulin).

[0030] (2) Preparation of gold nanocluster particles (BSA-GNC-PBA-Insulin) responsive to blood glucose regulation

[0031] 1) Preparation of BSA-coated gold nanocluster particles (BSA-GNCs)

[0032] Contains HAuCl 4 . The BSA mixed solution was reacted at 35-40° C. for 10-18 h under the condition of pH ≥ 12 to obtain BSA-coated gold nanocluster particles (BSA-GNCs).

[0033] 2) Convert the amino groups on the surface of BSA to carboxyl groups

[0034] First add glutaraldehyde to the B...

Embodiment 2

[0042] Example 2 Preparation of microneedle patch for intelligent blood sugar regulation

[0043] (1) Microneedle template

[0044] The microneedle template was purchased from Blueacre Technology Company in Ireland. The microneedle template was made of silicone material, and its design and size were as follows: figure 1 As shown: the template contains a 11×11 array of conical hole structures, wherein the diameter of the upper base of each conical hole is 300-400 μm, the height is 600-800 μm, and the distance between adjacent conical holes is 600 μm.

[0045] (2) Preparation of microneedle patch

[0046] The preparation of the microneedle patch includes the following steps:

[0047] 1) Prepare a biocompatible hydrogel solution. For example, biocompatible hydrogels include gelatin / starch hydrogels, sodium alginate hydrogels, hyaluronic acid hydrogels, polyvinyl alcohol hydrogels, and the like.

[0048] 2) Adding drugs for intelligent regulation of blood sugar (GNC-FPBA-Insul...

Embodiment 3

[0053] Example 3 Using different hydrogel materials to prepare microneedle patches for intelligent regulation of blood sugar

[0054] According to the method in Example 2, different hydrogel materials were used to prepare smart blood sugar regulation.

[0055] (1) Gelatin / starch as hydrogel material

[0056] Dissolve starch and gelatin with a mass ratio of 1:1 in deionized water respectively, heat to 60°C, stir for 30 minutes to fully dissolve, and prepare gelatin and starch with a concentration of 5% (w / v) (total concentration of gelatin+starch 10%) gelatin / starch solution.

[0057] An appropriate amount of medicine for intelligently regulating blood sugar is added to the gelatin / starch solution to obtain a medicine-containing gelatin / starch solution.

[0058] Use a pipette gun to take 50 μL of drug-containing gelatin / starch solution and deposit it directly on the surface of the microneedle template, and place it under vacuum (400mmHg) for 15 minutes to remove the air bubbl...

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Abstract

The invention discloses a microneedle patch for intelligently regulating blood sugar and a preparation method thereof, belonging to the field of biomedicine. The intelligent microneedle part of the microneedle patch for regulating blood sugar of the present invention is filled with the medicine for intelligently regulating blood sugar, the medicine carrier material, the sensitive switch factor of glucose response, and the medicine molecule. Fill the drug-containing hydrogel solution into the microneedles of the microneedle template by vacuuming and centrifuging; and prepare the base of the microneedle patch with the drug-free hydrogel solution by centrifuging again, The hydrogel material is solidified by a suitable method, and after drying, the microneedle patch is peeled off from the template to obtain a microneedle patch for intelligently regulating blood sugar. The microneedle patch of the present invention can puncture the skin, and intelligently release the contained insulin in the body according to the blood sugar concentration, so as to intelligently regulate the blood sugar level. Through the invention, painless, intelligent response blood sugar regulation is realized, and it is expected to guide the integration of diagnosis and treatment of diabetes.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a microneedle patch for intelligently regulating blood sugar and a preparation method thereof. Background technique [0002] Diabetes mellitus is a metabolic disease in which high glucose in the body is caused by insufficient insulin secretion or impaired insulin biological action. Among them, type 1 diabetes is due to autoimmune destruction of pancreatic beta cells leading to insufficient insulin secretion, and type 2 diabetes is a combination of insulin resistance and impaired insulin secretion. In recent years, diabetes has become an increasingly serious threat to public health in the world. According to statistics, in 2017, there were about 425 million adult patients with type 1 and type 2 diabetes in the world, and China became the country with the largest population of diabetics in the world with 114.4 million adult patients. [0003] For patients with type 1 diabetes and advan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61K47/69A61K47/54A61K47/52A61K38/28A61P3/10
CPCA61K38/28A61K47/52A61K47/54A61K47/6929A61M37/0015A61P3/10A61M2037/0023A61M2037/0061A61M2037/0053A61K9/0021A61M2037/0046A61K9/06A61K47/42
Inventor 雷祎凤刘胜张玉洁李银萍
Owner WUHAN UNIV
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