A kind of nano antibacterial agent and preparation method thereof
A nano-antibacterial agent and antibiotic technology, applied in the field of antibacterial agents and their preparation, can solve the problems of non-targeting, low utilization rate of antibiotics, poor biocompatibility in the field of antibacterial, etc., achieve simple and low-cost raw materials, and improve effective utilization The effect of energy saving and simple synthesis method
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specific Embodiment approach 1
[0038] Embodiment 1: In this embodiment, a kind of nano antibacterial agent is sodium hyaluronate to modify the surface of the synergistic system of MOF and antibiotics; the synergistic system of MOF and antibiotics is that the antibiotics are encapsulated in the zeolite imidazolate framework material ZIF -8 in.
specific Embodiment approach 2
[0039] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the described zeolite imidazolate framework structure material ZIF-8 is made of Zn(NO) 3 ·6H 2 O provides metal ions, 2-methylimidazole is used as a ligand, and deionized water is used as a dispersion medium, which is formed by cross-linking interaction at room temperature. Other steps are the same as in the first embodiment.
specific Embodiment approach 3
[0040] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the antibiotics are tetracycline antibiotics, aminoglycoside antibiotics, lactam antibiotics or polypeptide antibiotics. Other steps are the same as those in Embodiment 1 or 2.
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