Nasal secretion acquisition retention device, acquisition retention processing method, and applications of nasal secretion acquisition retention device and acquisition retention processing method

Abstract

The invention provides a nasal secretion acquisition retention device, an acquisition retention processing method, and applications of the nasal secretion acquisition retention device and the acquisition retention processing method, and belongs to the technical field of medical equipment and method. According to the nasal secretion acquisition retention device, the adopted elements are produced through standard production; operation is more convenient, safe, and healthy; errors caused by equipment and methods in artificial sample loading process are reduced; stabilized, standard nasal secretion samples with higher homogeneity can be obtained for clinical detection. The invention also provides the acquisition retention processing method of the nasal secretion. The nasal secretion acquisition retention device is used for acquisition and retention processing of nasal secretion; the nasal secretion liquid samples obtained through centrifugation are subjected to freeze condensation and freeze drying so as to obtain free-dried powder; the free-dried powder is diluted, and is subjected to corresponding detection, so that it is possible to ensure the dilution rate of nasal secretion is uniform, and a problem in the prior art that false negative detection results are caused by different dilution rate in nasal secretion acquisition process. The invention also provides applications of thenasal secretion acquisition retention device and the acquisition retention processing method.

Description

technical field [0001] The invention relates to the technical field of medical equipment and methods, in particular to a device for collecting and indwelling nasal secretions, a collection and indwelling treatment method, and an application. Background technique [0002] The prevalence of allergic rhinitis (Allergic Rhinitis, AR) in the world is 10-25%. The self-reported prevalence of AR in large and medium-sized cities in China has risen from 11.1% in 2005 to 17.6% in 2011. The prevalence rate increased from 8.7% to 20.2%. The diagnosis of allergic rhinitis is mainly based on the patient's clinical symptoms and signs, medical history and allergen identification test results. Among them, the determination of allergens plays an important role in the diagnosis of allergic rhinitis and subsequent immunotherapy. At present, clinical allergen determination mainly relies on skin prick test and serum specific IgE detection. The skin prick test is easily affected by oral drugs, a...

AI Technical Summary

Problems solved by technology

[0004] At present, the tools and materials used to collect nasal secretions are different, generally simple gauze, hand-made expansion sponge or negative pressure suction device, there is no strict standardized device and method; at the same time, due to the rough collection device, The patient’s experience is not good; in addition, in order to completely transfer and collect the nasal secretions in the collection materials, different volumes of stabilizing solutions that can dissolve cytokines and proteins in the nasal secretions are added, that is, the nasal secretions are diluted during the collection process. The ratio is different, and the collected nasal secretions need to be calibrated according to the weight of the nasal secretions. Therefore, it is difficult to obtain stable and standardized nasal secretions that can be used for clinical detection of specific IgE detection.

Images