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Efficient preparation method of L-alpha-glycerylphosphorylcholine

A glycerophosphatidylcholine, high-efficiency technology, applied in chemical instruments and methods, phosphorus organic compounds, compounds of Group 5/15 elements of the periodic table, etc., can solve problems such as low yields

Inactive Publication Date: 2018-11-13
WUHU FOMAN BIOPHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although the above method can prepare glycerol phosphatidylcholine, it generally has a low yield

Method used

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  • Efficient preparation method of L-alpha-glycerylphosphorylcholine
  • Efficient preparation method of L-alpha-glycerylphosphorylcholine

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preparation example Construction

[0021] The invention provides a high-efficiency preparation method of glycerol phosphatidylcholine, comprising:

[0022] 1) mixing vanadium chloride, copper salt, tin salt, nano rare earth oxide and alcohol to form a mixed solution;

[0023] 2) mixing the mixed solution and water, and then performing a solvothermal reaction to obtain a reaction product;

[0024] 3) Calcining the reaction product to obtain a catalyst;

[0025] 4) mixing phosphatidylcholine, water, and the catalyst, followed by alcoholysis, and finally performing column chromatography purification to obtain L-α-glycerophosphatidylcholine.

[0026] In step 1) of the above-mentioned preparation method, the consumption of materials can be selected in a wide range, but in order to further improve the yield of the preparation method, preferably, in step 1), the vanadium chloride, copper salt, The dosage ratio of tin salt, nano rare earth oxide and alcohol is 10mmol: 0.2-0.6mmol: 3-6mmol: 0.05-0.15mmol: 20-40mL.

...

Embodiment 1

[0036] 1) Mix vanadium chloride, copper salt (copper chloride), tin salt (tin methanesulfonate), nano-rare earth oxide (nano-cerium oxide) and alcohol (ethanol) according to 10mmol: 0.4mmol: 4mmol: 0.09mmol: 30mL The dosage ratio is mixed (the mixing temperature is 25°C, and the mixing time is 50min) to form a mixed solution;

[0037] 2) Mix the mixed solution and water according to the volume ratio of 1:1.8 (the mixing temperature is 25°C, the mixing time is 50min), and then carry out solvothermal reaction (the reaction temperature is 130°C, the reaction time is 7h) to obtain the reaction product;

[0038] 3) The reaction product is calcined (from 25°C to 200°C at a rate of 1.8°C / min and kept for 3 hours, then heated to 470°C at a rate of 1°C / min and kept for 3.5 hours, then cooled to 25° C.) to prepare Catalyst A1.

Embodiment 2

[0040] 1) Vanadium chloride, copper salt (copper sulfate), tin salt (tin ethanesulfonate), nano rare earth oxide (nano samarium oxide) and alcohol (propanol) according to 10mmol: 0.2mmol: 3mmol: 0.05mmol: 20mL is mixed in proportion (mixing temperature is 15°C, mixing time is 60min) to form a mixed solution;

[0041] 2) Mix the mixed solution and water according to the volume ratio of 1:1.5 (the mixing temperature is 15°C, the mixing time is 60min), and then perform solvothermal reaction (the reaction temperature is 120°C, the reaction time is 8h) to obtain the reaction product;

[0042] 3) Calcining the reaction product (increasing the temperature from 15°C to 180°C at a rate of 1.5°C / min and maintaining it for 2 hours, then raising the temperature to 450°C at a rate of 0.8°C / min and maintaining it for 3 hours, then cooling to 15°C ℃) to prepare catalyst A2.

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Abstract

The invention discloses an efficient preparation method of L-alpha-glycerylphosphorylcholine. The preparation method comprises the following steps: (1) mixing vanadinu chloride, copper salt, tin salt,nano rare earth oxide and alcohol to form a mixed solution; (2) mixing the mixed solution with water, then carrying out solvothermal reaction to obtain a reaction product; (3) calcining the reactionproduct to prepare a catalyst; and (4) mixing phosphatidylcholine, the water and the catalyst, then carrying out alcoholysis reaction, and finally carrying out column chromatography purification to prepare L-alpha-glycerylphosphorylcholine. The preparation method is capable of efficiently preparing L-alpha-glycerylphosphorylcholine.

Description

technical field [0001] The invention relates to the preparation of glycerol phosphatidylcholine, in particular to an efficient preparation method of glycerol phosphatidylcholine. Background technique [0002] Glycerol phosphatidylcholine is the product of two fatty acyl groups on the phosphatidylcholine (PC) molecule being completely hydrolyzed. It has a significant effect on stabilizing the cognitive ability of the brain, and can even repair some of the early senile dementia patients. Impaired cognitive abilities. Unlike drugs that inhibit the breakdown of acetylcholine, GPC stimulates the body to produce new phosphatidylcholine. Animal studies have shown that GPC can prevent memory loss. Compared with a control group of experimental conditions, it was found that older mice fed GPC mice had less loss of neural connections in the hippocampus, an area of ​​the brain dedicated to memory and learning. Based on a review of 13 clinical trial reports, scientist Kidd PM conclude...

Claims

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Application Information

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IPC IPC(8): C07F9/09
CPCC07F9/091
Inventor 苏福男
Owner WUHU FOMAN BIOPHARMA CO LTD
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