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Superhydrophilic coating with function of catalyzing NO long-period stable release and preparation method thereof

A super-hydrophilic and functional technology, applied in the field of medical materials, can solve the problems of limited NO catalyst content and inability to achieve long-term effective NO release, achieve good anti-coagulation function, excellent resistance to fibrinogen adhesion, and inhibit activation. and aggregation effect

Active Publication Date: 2018-11-13
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the traditional NO-generating materials are grafted or immobilized NO catalysts on the surface of the material. The content of NO catalysts grafted or immobilized on the surface is limited, a

Method used

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  • Superhydrophilic coating with function of catalyzing NO long-period stable release and preparation method thereof

Examples

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Effect test

Embodiment 1

[0022] A super-hydrophilic coating with long-term and stable release function of catalytic NO, the preparation method of which comprises the following steps:

[0023] (1) Polishing, cleaning and drying medical stainless steel materials;

[0024] (2) placing the treated base material in an acetic acid-sodium acetate buffer solution with a pH value of 4, then adding gallic acid, L-arginine, cystamine and concentrated nitric acid with a mass fraction of 65%-68%, The final concentrations of gallic acid, L-arginine, cystamine and concentrated nitric acid are 0.01mg / mL, 0.01mg / mL, 0.01mg / mL respectively, the mass fraction of concentrated nitric acid is 34%, and then react at 40°C for 30h;

[0025] (3) Submerge the product obtained in step (2) in deionized water, ultrasonically clean it 3 times for 5 minutes each time, and then dry it under nitrogen to obtain the obtained product.

Embodiment 2

[0027]A super-hydrophilic coating with long-term and stable release function of catalytic NO, the preparation method of which comprises the following steps:

[0028] (1) polishing, cleaning and drying the nickel-titanium alloy material;

[0029] (2) Place the treated base material in a phthalic acid-hydrochloric acid buffer solution with a pH value of 3.5, then add epigallocatechin gallate (EGCG), ethylenediamine, copper chloride and mass fraction It is 30% hydrogen peroxide solution, the final concentrations of epigallocatechin gallate (EGCG), ethylenediamine, and copper chloride are 1 mg / mL, 2 mg / mL, and 1 mg / mL respectively, and the hydrogen peroxide solution The mass fraction is 15%, and then reacted at 30°C for 10h;

[0030] (3) Submerge the product obtained in step (2) in deionized water, ultrasonically clean it 3 times for 5 minutes each time, and then dry it under nitrogen to obtain the obtained product.

Embodiment 3

[0032] A super-hydrophilic coating with long-term and stable release function of catalytic NO, the preparation method of which comprises the following steps:

[0033] (1) cleaning and drying the polytetrafluoroethylene material;

[0034] (2) Place the treated base material in 2-(N-morpholine)ethanesulfonic acid buffer solution with a pH value of 6, then add epicatechin gallate (ECG), 1,8-diamino Octane, selenocystamine, and sodium periodate solutions, the final concentrations of epicatechin gallate (ECG), 1,8-diaminooctane, selenocystamine, and sodium periodate solutions were 2 mg each / mL, 4mg / mL, 2mg / mL and 4mg / mL, then react at 25°C for 2h;

[0035] (3) Submerge the product obtained in step (2) in deionized water, ultrasonically clean it 3 times for 5 minutes each time, and then dry it under nitrogen to obtain the obtained product.

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Abstract

The invention provides a superhydrophilic coating with the function of catalyzing NO long-period stable release and a preparation method thereof. The preparation method comprises the following steps of performing pretreatment on the substrate material surface; putting the treated substrate material in partial acid buffer liquid; then, adding polyphenol compounds, multi-amine compounds, NO catalysts and oxidants for reaction; soaking a product obtained through reaction in deionized water; performing ultrasonic cleaning; then, performing drying under the nitrogen gas condition; preparing the superhydrophilic coating. The method has the advantages that the operation is simple; the reaction conditions are mild; the prepared coating material contains polyphenol compounds, a large number of functional groups such as carboxyl, phenolic hydroxyl groups, benzoquinonyls and amido groups and metal ions or chemicals capable of catalyzing an NO donor to release NO; the metal ions and the chemicalsmutually act with phenolic hydroxy functional groups or act with a system Pi-Pi accumulation for realizing the long-period existence of NO catalysts; further, the long-period sustained release function of NO is realized; the superhydrophilic coating can be used for preparation of materials for resisting blood coagulation, resisting hyperplasia, promoting endothelium growth, resisting tumor and thelike.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to a super-hydrophilic coating with the function of catalyzing the long-term stable release of NO and a preparation method thereof, which can be used for surface modification of materials such as anticoagulant, antiproliferation, endothelial promotion, and antitumor Research. Background technique [0002] Excellent hemocompatibility and cell compatibility are one of the conditions that biomaterials must meet, especially for cardiovascular implants that are in direct contact with blood (for example: vascular stents, heart valves, artificial blood vessels, pacemakers, etc. ), good blood compatibility is the most important consideration. Nitric oxide (NO) is an important cell messenger molecule that regulates the function of the cardiovascular system. Under the catalysis of nitric oxide synthase (NOS), L-arginine (L-Arginine Hydrochloride) is converted into L-guanidine (L-C...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/50A61L27/28A61L31/14A61L31/16A61L31/08
CPCA61L27/28A61L27/50A61L27/507A61L27/54A61L31/08A61L31/14A61L31/16A61L2300/114A61L2300/416A61L2300/42A61L2300/602A61L2300/606A61L2430/20A61L2430/22
Inventor 王云兵罗日方
Owner SICHUAN UNIV
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