Furacilin microsphere biocolloid liquid and preparation method thereof

A technology of nitrofurazone microspheres and biological colloids, which is applied in the field of nitrofurazone microspheres biological colloids and its preparation, which can solve the problems of inability to use gasification electric resection surgery, and achieve good effects of killing mold and promoting the healing of ulcers

Inactive Publication Date: 2018-11-06
JIANGSU HAIERZI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Pure nitrofurazone solution must be prepared with sodium chloride to have conductivity, and cannot be used for gasification electrotomy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of nitrofurazone microsphere biological colloid liquid, it is characterized in that: be made up of following component and mass fraction: nitrofurazone 0.2%; Sodium chloride 0.3%; Carboxymethyl chitosan 0.5%; Sodium alginate 0.1%; Calcium bicarbonate Or calcium chloride 0.35%; tea polyphenols 0.2%; glycine 1.2%; water for injection or purified water to a sufficient amount.

[0033] The preparation method of described nitrofurazone microsphere biological colloid liquid, prepares as follows:

[0034] Step 1) Add nitrofurazone into water for injection or purified water with sodium chloride and stir thoroughly to obtain solution ①, set aside;

[0035] Step 2) Mix and stir carboxymethyl chitosan with water for injection or purified water to fully dissolve to obtain liquid ②, set aside;

[0036] Step 3) Sodium alginate and glycine are miscible with water for injection or purified water and stirred to fully dissolve to obtain liquid ③, set aside;

[0037] Step 4) Mix ...

Embodiment 2

[0041] A kind of nitrofurazone microsphere biological colloid liquid, is made up of following component and mass fraction: nitrofurazone 0.5%; Sodium chloride 0.6%; Carboxymethyl chitosan 0.5%; Sodium alginate 0.65%; Calcium bicarbonate or calcium chloride 0.4%; tea polyphenols 0.3%; glycine 1.6%; water for injection or purified water to a sufficient amount.

[0042] The preparation method of described nitrofurazone microsphere biological colloid liquid, prepares as follows:

[0043] Step 1) Add nitrofurazone into water for injection or purified water with sodium chloride and stir thoroughly to obtain solution ①, set aside;

[0044] Step 2) Mix and stir carboxymethyl chitosan with water for injection or purified water to fully dissolve to obtain liquid ②, set aside;

[0045] Step 3) Sodium alginate and glycine are miscible with water for injection or purified water and stirred to fully dissolve to obtain liquid ③, set aside;

[0046] Step 4) Mix calcium bicarbonate or calciu...

Embodiment 3

[0050] A kind of nitrofurazone microsphere biological colloid liquid, it is characterized in that: be made up of following component and mass fraction: nitrofurazone 0.9%; Sodium chloride 0.6%; Carboxymethyl chitosan 0.7%; Sodium alginate 0.9%; Calcium bicarbonate Or calcium chloride 0.4%; tea polyphenols 0.35%; glycine 1.5%; water for injection or purified water to a sufficient amount.

[0051] The preparation method of described nitrofurazone microsphere biological colloid liquid, prepares as follows:

[0052] Step 1) Add nitrofurazone into water for injection or purified water with sodium chloride and stir thoroughly to obtain solution ①, set aside;

[0053] Step 2) Mix and stir carboxymethyl chitosan with water for injection or purified water to fully dissolve to obtain liquid ②, set aside;

[0054] Step 3) Sodium alginate and glycine are miscible with water for injection or purified water and stirred to fully dissolve to obtain liquid ③, set aside;

[0055] Step 4) Mix ...

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Abstract

The invention discloses furacilin microsphere biocolloid liquid and a preparation method thereof. In the biocolloid liquid provided by the invention, a microsphere wall material prepared from carboxymethyl chitosan and sodium alginate wraps a furacilin solution to form a nanometer microsphere colloid system. The biocolloid liquid is non-toxic, non-irritant and non-sensitized to the human body whenbeing applied to clinic, and has good molds and fungi- killing, antimicrobial, anti-inflammatory, analgesic and ulcerative surface healing-promoting effects. The biocolloid liquid is externally usedfor the treatment of trauma, burns, purulent dermatitis, otitis media, dacryocystitis, vaginitis, bladder irrigation, hemorrhoids and the like, and can also be used for washing vapor electrotomy of wounds to achieve the effects of cooling, maintaining clear surgery field and promoting wound healing.

Description

technical field [0001] The invention relates to nitrofurazone microsphere biological colloid liquid and a preparation method thereof, belonging to biological medicine. Background technique [0002] Clinically used to treat trauma, burns, suppurative dermatitis, otitis media, dacryocystitis, vaginitis, bladder irrigation, bedsores, etc. But the crystallization of nitrofurazone solution is the difficult problem of preparing nitrofurazone solution. At the same time, nitrofurazone is irritating to the mucous membrane, so it is of great significance to solve this problem. [0003] Simple nitrofurazone solution must be prepared with sodium chloride to have conductivity, and cannot be used for vaporization electrotomy. Contents of the invention [0004] In order to overcome the above-mentioned deficiencies in the prior art, the invention provides a kind of nitrofurazone microsphere biological colloid liquid, it is characterized in that: be made up of following component and mas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/345A61K31/722A61K31/734A61P31/04A61P31/10A61P29/00A61P17/02A61P17/00A61P27/16A61P27/02A61P15/02A61P13/10
CPCA61K9/10A61K31/345A61K31/722A61K31/734A61K47/22A61P13/10A61P15/02A61P17/00A61P17/02A61P27/02A61P27/16A61P29/00A61P31/04A61P31/10A61K2300/00
Inventor 胡军胡梦胡静雯
Owner JIANGSU HAIERZI BIOTECH CO LTD
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