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Modified porous chitosan gel matrix drug loading medical sponge, and preparation method thereof

A technology of porous chitosan and gel matrix, which is applied in the fields of pharmaceutical formulation, application, and medical science, and can solve the problems of small drug loading dose and insignificant drug effect, and achieve large drug loading dose, significant drug effect, natural good effect

Inactive Publication Date: 2018-11-02
SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problem that the existing chitosan gel matrix medical sponge has a small drug loading dose and no significant drug effect, and provides a modified porous chitosan gel matrix drug-loaded medical sponge and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) With microbial modifier, press 30% of microbial modifier, 15% of peptone, 12% of agar, after the balance is mixed with water, after cultivating at 20 ℃ for 36h, the gained culture liquid makes modified finishing solution; The mass ratio of cellulobacterium fusarium, acetobacter xylinum and lactic acid bacteria in the microorganism modifying agent is 1:4:6; the drug carrier liquid is prepared by mixing the bletilla striata polysaccharide drug carrier and pure water according to the solid-liquid ratio of 18:1;

[0033] (2) Chitosan solution with a mass fraction of 40% was taken as a synthetic raw material, polyethylene glycol was used as a cross-linking agent, and a chitosan porous gel with a porosity of 88% was obtained after a chemical cross-linking reaction.

[0034] (3) Utilize ultrasonic frequency to be the ultrasonic spray mode of 900Hz, with the modified finishing solution prepared in step (1), spray on the chitosan porous gel matrix surface prepared in step (2)...

Embodiment 2

[0038] (1) With microbial modifying agent, by microbial modifying agent 28%, peptone 12%, agar 8%, after the balance is mixed with water, after cultivating at 30 ℃ for 32h, the gained nutrient solution makes modified finishing solution; The mass ratio of cellulobacterium fusarium, Acetobacter xylinum and lactic acid bacteria in the microorganism modifying agent is 1:3:5; the drug carrier liquid is prepared by mixing chitosan drug carrier and pure water at a solid-to-liquid ratio of 10:1;

[0039] (2) Chitosan solution with a mass fraction of 32% was taken as a synthetic raw material, polyethylene glycol was used as a cross-linking agent, and a chitosan porous gel with a porosity of 75% was obtained after a chemical cross-linking reaction.

[0040] (3) Utilize ultrasonic frequency to be the ultrasonic spray mode of 800Hz, with the modified finishing solution prepared in step (1), spray on the chitosan porous gel matrix surface prepared in step (2), carry out modification treatme...

Embodiment 3

[0044] (1) With microbial modifier, press 20% of microbial modifier, 6% of peptone, 10% of agar, after the balance is mixed with water, after cultivating at 40 ℃ for 24h, the gained culture liquid makes modified finishing solution; The mass ratio of cellulobacterium fusarium, Acetobacter xylinum and lactic acid bacteria in the microorganism modifying agent is 1:2:3; the drug carrier liquid is prepared by mixing the cartin hydrochloride drug carrier and pure water at a solid-to-liquid ratio of 20:1;

[0045] (2) Chitosan solution with a mass fraction of 40% was taken as a synthetic raw material, polyethylene glycol was used as a cross-linking agent, and a chitosan porous gel with a porosity of 85% was obtained after a chemical cross-linking reaction.

[0046] (3) Utilize ultrasonic frequency to be the ultrasonic spray mode of 900Hz, with the modified finishing solution prepared in step (1), spray on the chitosan porous gel matrix surface prepared in step (2), carry out modificat...

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Abstract

The invention discloses a modified porous chitosan gel matrix drug loading medical sponge, and a peparation method thereof. The modified porous chitosan gel matrix drug loading medical sponge is prepared through following steps: a chitosan porous gel matrix is subjected to modification treatment using a microorganism modifying agent, and the polar groups on the surface of the obtained modified chitosan porous gel matrix are adopted to complete loading of a drug carrier. The microorganism modifying agent comprises cellfalcicula, acetobacter xylinum, and lactic acid bacteria; the drug carrier isa hydrophilic drug which is inert to the chitosan porous gel matrix. According to the preparation method, the microorganism modifying agent is adopted for biochemical reaction so as to generate a large amount of hydrophilic groups, a modifying finishing liquid containing high concentration hydrophilic groups is sprayed onto the surface of the chitosan porous gel to complete modification treatment; the drug carrier solution is sprayed onto the surface of the modified chitosan porous gel matrix, and drug loading is completed through bonding effect, the drug carrying amount of the matrix on thehydrophilic drug is increased. The modified porous chitosan gel matrix drug loading medical sponge is large in drug loading amount, excellent in drug using effect, and long in drug effect lasting period.

Description

technical field [0001] The invention relates to the field of new medical materials, in particular to a modified porous chitosan gel matrix drug-loaded medical sponge and a preparation method thereof. Background technique [0002] There are many kinds of existing medical sponges, which can be classified into synthetic and biological according to the material of the sponge. In view of the increasingly high requirements for the biocompatibility of medical sponges, biological medical sponges have also become the main materials used. The material sources of biological sponges that are currently studied mainly include collagen, chitin and its derivatives, and alginate. Natural biopolymer materials have the characteristics of resolvability, and different materials have their unique biological activities, which is an important trend in the future development of the field of medical materials. Among them, collagen is the main extracellular matrix component, with a triple helical st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L24/08A61L24/00C08J9/36C08L5/08
CPCA61L26/0023A61L24/001A61L24/0015A61L24/0031A61L24/0036A61L24/08A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L2300/606A61L2400/04C08J9/36C08J2305/08C08L5/08
Inventor 舒春柳洪艳
Owner SICHUAN LIZHI JIUCHUANG INTPROP OPERATION CO LTD
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