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External traditional Chinese medicine preparation for treating effusion of knee joint

A technology for knee joint effusion and external preparation, which is applied in the directions of medical preparations, pharmaceutical formulations, and drug combinations containing active ingredients, can solve problems such as adverse reactions and increase the probability of joint infection, achieve good curative effects, and reduce knee joint circumferences. diameter, the effect of safe use

Inactive Publication Date: 2018-11-02
上海昱烁管理咨询有限公司
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In current clinical practice, the prevention and treatment of knee osteoarthritis and its secondary joint effusion often use NSAIDS drugs to reduce inflammation and analgesia, or use chondroitin sulfate and glucosamine drugs to protect articular cartilage, or perform joint puncture to draw fluid, or Intra-injection of sodium hyaluronate, glucocorticoids, etc. improves synovial fluid secretion. However, clinical practice shows that long-term use of NSAIDS drugs can lead to adverse reactions such as gastrointestinal tract; joint puncture injection is an invasive treatment, and repeated injections may increase joint infection Probability; based on the status quo of the prior art, the inventor of the present application intends to provide a new safe, effective and convenient treatment drug, specifically related to a traditional Chinese medicine external preparation for the treatment of knee joint effusion

Method used

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  • External traditional Chinese medicine preparation for treating effusion of knee joint
  • External traditional Chinese medicine preparation for treating effusion of knee joint
  • External traditional Chinese medicine preparation for treating effusion of knee joint

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Take 1000 g of Glauber's salt and 100 g of borneol by weight, form powder, and after physical mixing, put into non-woven bags to prepare traditional Chinese medicine external dressings;

[0019] A total of 64 patients with knee osteoarthritis with mild to moderate joint effusion diagnosed by magnetic resonance imaging, aged between 40 and 75 years old, were selected and randomly divided into two groups after signing the informed consent. After mixing 1000 g of Glauber's salt and 100 g of borneol, put it into a non-woven bag, and apply it to the affected area for 8 hours a day. Pain visual analogue scale (VAS score) and Western Ontario and Mc Master Universities Osteoarthritis Index (WOMAC score), some patients underwent knee MRI before and after treatment respectively; the results showed that after 2 weeks of treatment, the indicators in the two groups were significantly better than those before treatment Improvement (pfigure 1 , 2 There were no obvious adverse reactio...

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Abstract

The invention belongs to the technical field of biological medicine and relates to an external traditional Chinese medicine preparation for treating effusion of knee joint. The external traditional Chinese medicine preparation provided by the invention is characterized in that mirabilite and borneol are used for preparing medicine composition which can be used for preparing the external traditional Chinese medicine preparation. A patient suffering from knee osteoarthritis, confirmed by magnetic resonance, with mild or moderate effusion of knee joint is selected, and the application result of external application of clinical trial shows that the effect in treating of effusion of knee joint is relatively good; the external traditional Chinese medicine preparation has the advantages that theknee joint cross-section diameter, VAS (Visual Analogue Scale) value and WOMAC (Western Ontario and Mc Master Universities Osteoarthritis Index) score of a patient suffering from knee osteoarthritis can be reduced remarkably, no obvious side effect is caused during treating, and the use is safe, effective and convenient.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a traditional Chinese medicine external preparation, in particular to a traditional Chinese medicine external preparation for treating knee joint effusion. Background technique [0002] Knee osteoarthritis is a chronic, degenerative joint disease caused by cartilage degeneration and bone hyperplasia of the knee joint. According to statistics, 80% of people over the age of 50 suffer from proliferative changes in the knee joint, and about 90% over the age of 60 and up to 100% over the age of 70 suffer from hyperplastic changes of the knee joint. Studies have shown that in the process of knee joint degeneration, factors such as osteophytes and shed cartilage fragments induce inflammatory changes in the synovium, promote synovial hyperplasia and exudation, form joint effusion, and secrete mediators that directly or indirectly lead to cartilage degradation to the joint. In the fluid, the join...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61P19/02A61P19/08A61K31/045
CPCA61K9/0014A61K31/045A61K33/04A61K2300/00
Inventor 尚西亮吴金峰
Owner 上海昱烁管理咨询有限公司
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