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PH response type star-like amphiphilic polymer and preparation method thereof

An amphiphilic polymer and star-shaped technology, which is applied in the field of pH-responsive star-shaped amphiphilic polymers and their preparation, can solve the problems of less structure types, and achieves low molecular weight distribution coefficient, good application prospect and high yield. Effect

Inactive Publication Date: 2018-10-02
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are still relatively few structural types of star-shaped block polymers currently used for biomedical polymer materials (mainly concentrated on pentaerythritol as the core), so it is urgent to design new star-shaped block polymers to construct new biomedical materials. High molecular polymer materials to meet the needs of clinical applications

Method used

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  • PH response type star-like amphiphilic polymer and preparation method thereof
  • PH response type star-like amphiphilic polymer and preparation method thereof
  • PH response type star-like amphiphilic polymer and preparation method thereof

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Embodiment 1

[0035] Such as figure 1 As shown, the synthetic steps of the present embodiment include:

[0036] (1) Synthesis of adamantyl polycaprolactone

[0037] Add 1,3,5,7-tetrahydroxyadamantane (0.04g, 0.2mmol) into the Shrek reaction flask containing a stirring bar, and after pumping air and argon for 3 times, the hydrophobic monomer ε-hexyl Lactone (9.12g, 8mmol), the first catalyst stannous octoate (0.009g, 0.022mmol) and the first reaction solvent anhydrous toluene (30mL) were added into the reaction flask through a syringe, and after ultrasonication for 20min, the reaction was carried out at 90°C for 36h to obtain Crude product containing adamantyl polycaprolactone.

[0038] In order to obtain pure adamantyl polycaprolactone, after the reaction is completed, the excess first reaction solvent toluene in the crude product is removed by rotary evaporation; dissolved with the second solvent tetrahydrofuran, and slowly added dropwise to 10 times the first In the precipitating agent...

Embodiment 2

[0049] (1) Synthesis of adamantyl polycaprolactone

[0050] Add 1,3,5,7-tetrahydroxyadamantane (0.04g, 0.2mmol) into the Shrek reaction flask containing a stirring bar, pump air-argon in this way for 3 times, and the hydrophobic monomer ε-hexene Ester (28.5g, 25mmol), the first catalyst zinc acetate (0.029g, 0.155mmol) and the first reaction solvent anhydrous xylene (30mL) were added into the reaction flask through a syringe, and after ultrasonication for 20min, they were reacted at 100°C for 12h to obtain Crude product of adamantyl polycaprolactone.

[0051] In order to obtain pure adamantyl polycaprolactone, after the reaction is completed, the redundant first reaction solvent xylene in the crude product is removed by rotary evaporation; dissolved with the second solvent tetrahydrofuran, and then slowly added dropwise to 10 times the amount A precipitating agent, ether, filtered the precipitated solid, and repeated this operation 2-3 times to obtain adamantyl polycaprolacto...

Embodiment 3

[0059] (1) Synthesis of adamantyl polycaprolactone

[0060] Add 1,3,5,7-tetrahydroxyadamantane (0.04g, 0.2mmol) into the Shrek reaction flask containing a stirring bar, and after pumping air and argon for 3 times, the hydrophobic monomer ε-hexyl Lactone (42.75g, 37.5mmol), the first catalyst aluminum isopropoxide (0.086g, 0.419mmol) and the first reaction solvent anhydrous toluene (30mL) were added to the reaction bottle through a syringe, and after ultrasonication for 20min, the reaction was carried out at 130°C for 48h , to obtain a crude product containing adamantyl polycaprolactone.

[0061] In order to obtain pure adamantyl polycaprolactone, after the reaction is finished, the excess first reaction solvent toluene in the crude product is removed by rotary evaporation; dissolved with the second solvent methylene chloride, and then slowly added dropwise to 10 times In methanol as the first precipitant, filter the precipitated solid, and repeat this operation 2 to 3 times; ...

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Abstract

The invention belongs to the technical field of high-molecular polymer materials for biological medicines, and particularly relates to a pH response type star-like amphiphilic polymer and a preparation method thereof. The invention provides the pH response type star-like amphiphilic polymer of a chemical structure of formula (I) as shown in the specification, in the formula, adamantane which is non-toxic and odor-free, good in biocompatibility and unique in spatial configuration is adopted as a core of the pH response type star-like amphiphilic polymer, polycaprolactone which is good in biocompatibility and biodegradability is adopted as a hydrophobic block, a poly-alkaline type polymer, namely polymethylacrylic acid lignocaine ethyl ester, is adopted as a pH response block, and polymethylacrylic acid methoxy polyethylene glycol ester is adopted as a hydrophilic block. The invention further provides a preparation method of the pH response type star-like amphiphilic polymer. The preparation method is simple to operate, gentle in reaction condition, easy in product purification process and controllable in structure. The pH response type star-like amphiphilic polymer has a molecular weight distribution coefficient less than 1.3, and a product yield as high as 85% or greater.

Description

technical field [0001] The invention belongs to the technical field of high molecular polymer materials for biomedicine, and in particular relates to a pH-responsive star-shaped amphiphilic polymer and a preparation method thereof. Background technique [0002] With the rapid development of polymer synthesis technology, functional polymers with different structures have been widely studied and applied in the field of biomedical polymer materials. This type of biomedical polymer usually needs to have the characteristics of biocompatibility, degradability, stimulus-response and clear chemical structure. [0003] Usually, polymers are obtained through rational structure design and living-controllable polymerization methods, such as living ring-opening polymerization, atom transfer radical polymerization, etc. Atom transfer radical polymerization is a good method for synthesizing low molecular weight distribution coefficient acrylate block copolymers and methacrylate block copo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00
CPCC08F293/005C08F2438/01
Inventor 郭建维羊惠燕
Owner GUANGDONG UNIV OF TECH
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