Tc-99m marked ciprofloxacin xanthate complex, as well as preparation method and application thereof
A technology of ciprofloxacin and xanthate, applied in the fields of radiopharmaceutical chemistry and clinical nuclear medicine, can solve the problems of low specificity, false positives and low labeling rate.
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[0043] Describe the present invention in detail below by embodiment: a kind of 99m TcN-CPF2XT complex, its structural formula is as follows:
[0044]
[0045] a. Synthesis of Ligand CPF2XT
[0046] Weigh 2.00g (6.00mmol) of ciprofloxacin, dissolve it in 100mL of anhydrous methanol, slowly add 1.72g (8.90mmol) p-toluenesulfonic acid, stir until the mixture is uniform and fully dissolved. Heated in an oil bath at 80°C, stirred and refluxed for 12 hours, and cooled to room temperature. Slowly add NaHCO 3 solution, with CH 2 Cl 2 Extraction (100mL×3), the organic phases were combined and dried over anhydrous magnesium sulfate, filtered, and rotary evaporated to obtain a white solid, compound I;
[0047] Weigh compound I1.00g (2.88mmol), K 2 CO 3 1.20g (8.64mmol) and bromoethanol 0.72g (5.76mmol), add 50mL of acetonitrile as solvent, heat in an oil bath at 80°C, stir and reflux for 12h; add appropriate amount of deionized water to the reaction system to dissolve, and use ...
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