Near infrared quantitative analysis model for radix glycyrrhizae medicinal material and detection method and standard

A technology for quantitative analysis of licorice herbs, which is applied in the direction of material analysis, analysis materials, and measurement devices by optical means, to achieve the effects of reducing detection costs, accurate results, and shortening detection time.

Inactive Publication Date: 2018-09-11
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there is no relevant literature report on the establishment of a simultaneous rapid detection method and standard for multiple indicators of licorice medicinal materials and decoction pieces based on near-infrared spectroscopy. Therefore, it is of great significance and prospect to provide rapid quantitative analysis methods and standards for quality indicators of licorice medicinal materials

Method used

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  • Near infrared quantitative analysis model for radix glycyrrhizae medicinal material and detection method and standard
  • Near infrared quantitative analysis model for radix glycyrrhizae medicinal material and detection method and standard
  • Near infrared quantitative analysis model for radix glycyrrhizae medicinal material and detection method and standard

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Experimental program
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Effect test

Embodiment 1

[0073] Collection of licorice samples from different origins and determination of quality indicators moisture, total ash, liquiritin and glycyrrhizic acid.

[0074] Seventy-seven batches of licorice material samples were collected from licorice producing areas across the country as calibration set samples. The samples were pulverized separately and passed through a 40-mesh sieve. spare. According to the method specified in the Chinese Pharmacopoeia 2015 edition of licorice, the contents of moisture, total ash, liquiritin and glycyrrhizic acid were detected. The instruments, reagents, materials and experimental methods used are as follows.

[0075] SA1. Instruments, reagents and materials.

[0076] SA1.1 Instrument: Agilent 1260 high performance liquid chromatograph; Mettler XS-205 electronic analytical balance (1 / 100,000); Bruker Matrix-F Fourier transform near-infrared spectrometer; Shanghai Airlang WFO-700W air supply type Constant temperature drying oven.

[0077] SA1.2 ...

Embodiment 2

[0096] On the basis of Example 1, a method for rapidly detecting the moisture content of licorice herbs based on near-infrared spectroscopy technology is established, which specifically includes the following steps:

[0097] SB1. Collection of NIR Spectra

[0098] Take 77 batches of licorice material sample powder in the calibration set described in Example 1, take about 3 g of each batch, and put them into glass sample bottles with stoppers respectively. The near-infrared spectrum was scanned with a Bruker Matrix-F Fourier transform near-infrared spectrometer. Resolution: 8cm -1 ; Number of scans: 32Scans; Spectral range: 12000 cm -1 ~4000cm -1 . Each sample was measured 6 times in parallel, and the average value was taken as the original spectrum of the sample. The environmental conditions were: temperature 23°C±0.5°C, relative humidity 40%±2%. To obtain the original near-infrared absorption spectrum of licorice herbs, see figure 1 .

[0099] SB2. Using Partial Least ...

Embodiment 3

[0115] On the basis of Example 1, a method for rapidly detecting the total ash content of licorice herbs based on near-infrared spectroscopy technology is established, which specifically includes the following steps:

[0116] SC1. Collection of NIR Spectra

[0117] Take 77 batches of licorice material sample powder in the calibration set described in Example 1, take about 3 g of each batch, and put them into glass sample bottles with stoppers respectively. The near-infrared spectrum was scanned with a Bruker Matrix-F Fourier transform near-infrared spectrometer. Resolution: 8cm -1 ; Number of scans: 32Scans; Spectral range: 12000 cm -1 ~4000cm -1 . Each sample was measured 6 times in parallel, and the average value was taken as the original spectrum of the sample. The environmental conditions were: temperature 23°C±0.5°C, relative humidity 40%±2%. To obtain the original near-infrared absorption spectrum of licorice herbs, see figure 1 .

[0118] SC2. Using Partial Least...

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Abstract

The invention belongs to the technical field of traditional Chinese medicinal materials analysis and detection and the technical field of near infrared spectroscopic analysis and detection and relatesto a near infrared quantitative analysis model for a radix glycyrrhizae medicinal material, an establishment method and a detection method and standard for the radix glycyrrhizae medicinal material.The establishment method for the model comprises the following steps: collecting a radix glycyrrhizae medicinal material sample; measuring the content of a quality control index component of the radixglycyrrhizae medicinal material; acquiring a near infrared spectrum; preprocessing the original near infrared spectrum and determining an optimal preprocessing method and a modeling spectrum waveband; establishing a near infrared quantitative calibration model for the near infrared spectrum and a corresponding measured value of the content of the quality control index component of the radix glycyrrhizae medicinal material by use of a multivariate calibration method; verifying the near infrared quantitative calibration model. The detection method for the radix glycyrrhizae medicinal material comprises the following steps: acquiring and importing a near infrared spectrum of a radix glycyrrhizae sample into the quantitative calibration model and predicting the content of the quality controlindex component. According to the method, the radix glycyrrhizae medicinal material can be nondestructively detected rapidly, and the authenticity and the quality of the medicinal material can be qualitatively and quantitatively detected rapidly.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection of traditional Chinese medicinal materials and the technical field of near-infrared spectrum analysis and detection, and relates to a near-infrared quantitative analysis model and establishment method of licorice medicinal materials, a detection method and detection standards of licorice medicinal materials. Background technique [0002] Licorice is the dry root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhizainflata Bat. or Glycyrrhiza glabra L. of leguminous plant Glycyrrhiza uralensis Fisch. The roots and rhizomes of Glycyrrhizauralensis Fisch. are one of the main sources of traditional Chinese medicine licorice. It has the functions of invigorating spleen and Qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasms and relieving pain, and harmonizing various medicines. It is known as "ten prescriptions and nine herbs". In the first part...

Claims

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Application Information

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IPC IPC(8): G01N21/359
CPCG01N21/359
Inventor 王汉卿温奎申陶伟伟雍婧姣张霞高晓娟赵建军付慧玲柳全霞
Owner NINGXIA MEDICAL UNIV
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