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Application of benzoyl aconine in preparation of rheumatoid arthritis therapeutic drugs

A technology of benzoyl aconitine and arthritis, applied in the field of medicine, can solve the problems of large toxic and side effects of medication, strong medication compliance and the like

Inactive Publication Date: 2018-09-07
SICHUAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the disadvantages of existing drugs for the treatment of rheumatoid arthritis, such as large drug toxicity and side effects and strong drug compliance, to provide a drug that can produce low toxicity, high efficiency, and multi-action targets for the treatment of rheumatoid arthritis diseases. The natural medicine benzaldehyde aconitine and its use in the preparation of medicines for treating rheumatoid arthritis

Method used

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  • Application of benzoyl aconine in preparation of rheumatoid arthritis therapeutic drugs
  • Application of benzoyl aconine in preparation of rheumatoid arthritis therapeutic drugs
  • Application of benzoyl aconine in preparation of rheumatoid arthritis therapeutic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Study on the therapeutic effect of benzoyl aconitine on foot swelling caused by rheumatoid arthritis

[0026] The effect of benzoyl aconitine on rheumatoid arthritis was studied by simulating the swelling symptoms of rheumatoid arthritis caused by the swelling of rat feet caused by existing egg whites, and the following animal simulation experiments were carried out.

[0027] The specific experimental operations are as follows:

[0028] S1: 50 male rats with a body weight of (180±10) g were taken and randomly divided into 5 groups with 10 rats in each group, namely the model control group (N=10) and the dexamethasone acetate group (positive control group, ) ( N=10), low-dose benzoyl aconitine group (N=10), benzoyl aconitine medium-dose group (N=10), benzoyl aconitine high-dose group (N= 10).

[0029] S2: Mark the same part of the right hind paw of each rat before the test, and measure the thickness of the marked part of the right hind paw of each rat with a vernier ca...

Embodiment 2

[0043] Study on the mechanism of action of benzoyl aconitine on rheumatoid arthritis

[0044] The inventor studies the mechanism of action of benzoyl aconitine on rheumatoid arthritis through collagen-induced arthritis animal model experiments. The specific experimental operation steps are as follows:

[0045] S1: Take 70 SPF (no specific pathogen) male SD rats, weighing (140±10) g, and after adaptive feeding for 5 days, 10 rats were randomly selected as the normal control group, and the rest were modeled by collagen arthritis. .

[0046] S2: The modeling method refers to the existing relevant literature, specifically:

[0047]The acetic acid solution of bovine type Ⅱ collagen (CⅡ) (containing bovine CⅡ 2.0mg·ml) -1 ) and an equal volume of complete Freund's adjuvant (CFA), mixed thoroughly, and fully emulsified. liquid. Take 0.2ml of the emulsion and inject it at four points intradermally on the back and tail root (two points on the back and two points on the base of the ...

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Abstract

The invention belongs to the medicine field and particularly discloses application of benzoyl aconine in preparation of rheumatoid arthritis therapeutic drugs, the benzoyl aconine is taken as a natural medical material extractive, remarkable multi-acting target, low toxicity and high-efficiency therapeutic effects to the rheumatoid arthritis can be realized through multiple action mechanisms of anti-inflammation and detumescence, ankle pathologic change reduction, immune visceral organ pathologic change reduction and / or serum cell factor reduction, the cure rate of the rheumatoid arthritis patients is increased, the possibility of the medicine kinds and the dosage is reduced, and the benzoyl aconine has a remarkable and advanced meaning in the preparation of the rheumatoid arthritis therapeutic drugs.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new medicinal application of benzoyl aconitine, which is an important active component of monoester-type alkaloids in the medicinal preparation of Chuanwu, Caowu and Fuzi, that is, in the preparation of therapeutic drugs Use in rheumatoid arthritis drugs. Background technique [0002] Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by joint synovitis, mainly manifested as symmetrical, chronic, progressive polyarthritis. The global incidence is about 0.24%, with a high disability rate, more common in middle-aged women. The pathogenesis of RA is still unclear. The main pathological features are synovial tissue hyperplasia, inflammatory cell infiltration and pannus formation, and the destruction of cartilage and bone, which can eventually lead to joint deformity and loss of function. [0003] At present, the treatment of RA mainly uses drugs to relieve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61P29/00A61P19/02
CPCA61K31/439A61P19/02A61P29/00
Inventor 李晋奇顾平童荣生李杰王佳凤
Owner SICHUAN PROVINCIAL PEOPLES HOSPITAL
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