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Nerve injury resisting method of ischemic brain injury animal model

A technology of ischemic brain injury and animal models, which can be applied to nervous system diseases, drug combinations, pharmaceutical formulations, etc., and can solve problems such as unsatisfactory curative effects

Inactive Publication Date: 2018-09-07
LANZHOU UNIVERSITY
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Problems solved by technology

At present, the treatment drugs or methods for nerve damage caused by ischemic brain injury have not achieved satisfactory curative effect. In view of this situation, the present invention proposes a traditional Chinese medicine dilongsu as an anti-nerve injury drug for ischemic brain injury. , good curative effect, overcomes the disadvantages of using western medicine, and can provide a scientific basis for the later research and application of drugs with multiple functions and multiple targets

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  • Nerve injury resisting method of ischemic brain injury animal model
  • Nerve injury resisting method of ischemic brain injury animal model
  • Nerve injury resisting method of ischemic brain injury animal model

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Embodiment Construction

[0028] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0029] An anti-nerve injury method for an animal model of ischemic brain injury, comprising the following steps:

[0030] Step 1, the establishment method of animal model of ischemic brain injury

[0031] Taking 6-8 week-old mice as experimental animals, the experimental mice were anesthetized by ketamine / xylazine (100mg / kg, 15mg / mg, intraperitoneal injection), and the dose of ketamine / xylazine used was 100mg / kg, 15mg / mg, anesthetized by intraperitoneal injection, then the scalp was cut in the middle to expose the skull, the double-sided blade was glued to the skull, the screw was tightened to fi...

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Abstract

The invention discloses a nerve injury resisting method of an ischemic brain injury animal model. The nerve injury resisting method comprises the following steps of S1, establishing the ischemic braininjury animal model; S2, performing lumbricusion administration experiment; S3, performing behavioristics testing, measuring infarct volume, and observing the influence of the lumbricusion on the expression of VEGF (vascular endothelial growth factor) and CD34 related with ischemic penumbra and angiogenesis of an ischemic brain injury mouse; observing the influence of the lumbricusion on the protein expression of related VEGF, PI3K (phosphatidyl inositol-3-kinase) and AKT (protein kinase B) factors of the PI3K-AKT signal channels of a local ischemic brain injury mouse. The nerve injury resisting method has the advantages that according to the animal experiment, the optimum dosage of the lumbricusion for realizing the nerve protection effect on the ischemic brain injury animal is determined; according to the reliable testing indexes, the lumbricusion can be used for performing nerve protection on the ischemic brain injury.

Description

technical field [0001] The invention belongs to the technical field of anti-nerve injury, and in particular relates to an anti-nerve injury method for an animal model of ischemic brain injury. Background technique [0002] Stroke is a common disease, frequently-occurring disease, high mortality rate and disability rate, and no ideal treatment method has been found clinically. Although antithrombotic western medicines have definite curative effects, they have obvious adverse reactions, a single target of action, and the condition is prone to relapse. The traditional Chinese medicine Dilong has the advantages of less toxic and side effects and multiple targets. At present, the treatment drugs or methods for nerve damage caused by ischemic brain injury have not achieved satisfactory curative effect. In view of this situation, the present invention proposes a traditional Chinese medicine dilongsu as an anti-nerve injury drug for ischemic brain injury. , good curative effect, o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K35/62A61P9/10A61P25/00
CPCA61K31/352A61K35/62A61P9/10A61P25/00
Inventor 李娟李应东陈新年把昱萱李茂煜把多利高育鹏赵信科
Owner LANZHOU UNIVERSITY
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