Thermo-sensitive polymer as well as synthetic method and application thereof

A temperature-sensitive polymer and synthesis method technology, applied in the direction of medical preparations and pharmaceutical formulas of non-active ingredients, can solve the problems of narrow adjustable range, unfavorable precise adjustment, etc., and achieve the effect of easy promotion and simple preparation method

Inactive Publication Date: 2018-09-04
SUZHOU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the adjustable range of this type of polymer is narrow, and the LCST or UCST characteristics can only be adjusted in the range of 20% and 10%. Smaller polymer composition fluctuations correspond to larger LCST or UCST cloud point temperature changes, which is not conducive to accurate adjustment.

Method used

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  • Thermo-sensitive polymer as well as synthetic method and application thereof
  • Thermo-sensitive polymer as well as synthetic method and application thereof
  • Thermo-sensitive polymer as well as synthetic method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A thermosensitive polymer prepared by the following method:

[0038] (1) Add 0.71g glycidyl methacrylate, 3.76g 2-(2-methoxyethoxy) ethyl methacrylate, 0.051g trimethylsilylpropyne to a 100ml round bottom flask Ethyl-2-bromoisobutyrate, 0.150g 4,4'-dinonylbipyridyl and 10ml anisole, the reaction system was stirred and dissolved, and argon was bubbled for 30 minutes to remove oxygen, and then 0.026g bromine was added Cuprous chloride was polymerized at 80°C for 2.5 hours. The reaction product was diluted with tetrahydrofuran and passed through a neutral alumina column. The filtrate was concentrated and then precipitated in ether. The product was precipitated and washed twice, and then dried in vacuum at room temperature for 24 hours. To constant weight, obtain 3.87g glycidyl methacrylate and 2-(2-methoxyethoxy) ethyl methacrylate copolymer, product yield is 86.5%.

[0039] product 1 H NMR results as figure 1 As shown in (a), the result analysis shows that the degree o...

Embodiment 2

[0044] A thermosensitive polymer prepared by the following method:

[0045] (1) Add 2.84g glycidyl methacrylate, 0.94g 2-(2-methoxyethoxy) ethyl methacrylate, 0.053g trimethylsilylpropyne to a 100ml round bottom flask Ethyl-2-bromoisobutyrate, 0.152g 4,4'-dinonylbipyridyl and 10ml anisole, the reaction system was stirred and dissolved, and argon was bubbled for 30 minutes to remove oxygen, and then 0.025g bromine was added Cuprous chloride was polymerized at 80°C for 1.0 h. The reaction product was diluted with tetrahydrofuran and passed through a neutral alumina column. The filtrate was concentrated and then precipitated in ether. The product was precipitated and washed twice, and then dried in vacuum at room temperature for 24 h. To a constant weight, 3.49 g of glycidyl methacrylate and 2-(2-methoxyethoxy) ethyl methacrylate copolymer were obtained, and the product yield was 90.3%.

[0046] product 1 H NMR results as figure 2 As shown in (a), the result analysis shows th...

Embodiment 3

[0051] A thermosensitive polymer prepared by the following method:

[0052] (1) Add 2.12g glycidyl methacrylate, 2.83g 2-(2-methoxyethoxy) ethyl methacrylate, 0.061g trimethylsilyl propyne to a 50ml round bottom flask Ethyl-2-bromoisobutyrate, 0.183g 4,4'-dinonylbipyridine and 10ml anisole, the reaction system was stirred and dissolved, and argon was bubbled for 30 minutes to remove oxygen, and then 0.032g bromine was added Cuprous chloride was polymerized at 80°C for 1.5 hours. The reaction product was diluted with tetrahydrofuran and then passed through a neutral alumina column. The filtrate was concentrated and then precipitated in ether. The product was precipitated and washed twice, and then dried in vacuum at room temperature for 24 hours. To a constant weight, 4.36 g of glycidyl methacrylate and 2-(2-methoxyethoxy) ethyl methacrylate copolymer were obtained, and the product yield was 88.1%.

[0053] product 1 Analysis of H NMR results showed that the degree of polymer...

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Abstract

The invention discloses a thermo-sensitive polymer as well as a synthetic method and application thereof. A structure of the thermo-sensitive polymer is as shown in formula I. The synthetic method comprises the following steps: adding an initiator, a monomer and a ligand into a solvent, deoxygenating, adding cuprous bromide, reacting for 0.5 to 5 hours, washing product precipitates for a pluralityof times, drying, and obtaining a copolymer; dissolving the copolymer in a N,N-dimethyl formamide solution; and adding imidazole, reacting for 24 to 48 hours, precipitating a product, washing for a plurality of times, drying, and obtaining the thermo-sensitive polymer. The thermo-sensitive polymer can have different thermo-sensitive characteristics by adjusting the composition of the copolymer; and by adjusting the polymer composition in a wider range, the turbidity point temperature of LCST or UCST can be changed, and the thermo-sensitive polymer can be applied to various fields such as biochemistry, medicine or food of drug controlled release, catalyst step-by-step release, cell embedding and the like.

Description

technical field [0001] The invention belongs to the field of high-molecular polymers, and in particular relates to a temperature-sensitive polymer and its synthesis method and application. The polymer has a certain range of LCST (lower critical solution temperature) and UCST (higher critical solution temperature). Background technique [0002] Thermosensitive polymers are very sensitive to temperature, and are generally divided into low critical solution temperature (LCST) type and high critical solution temperature (UCST) type, corresponding to insolubility of the polymer in solution below and above the critical temperature, respectively. However, when referring to heat-sensitive polymers, it generally refers to polymers with LCST properties, because the number of polymers with UCST properties in water is very small. However, UCST-type polymers have potential applications in many ways relative to LCST-type polymers. Therefore, it is very important to develop new polymers w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/28C08F220/36A61K47/32
CPCA61K47/32C08F220/28C08F220/36C08F2438/01C08F220/285
Inventor 张干伟白仁碧沈舒苏雷建斌吴龙波郭晨晨方嘉隆
Owner SUZHOU UNIV OF SCI & TECH
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