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Molecularly imprinted polymer, chemiluminescence kit and detection method specific for phenothiazine drug family

A technology of phenothiazines and detection methods, applied in chemical instruments and methods, chemiluminescence/bioluminescence, and other chemical processes, to achieve strong tolerance, ensure safety, and reduce detection costs

Inactive Publication Date: 2020-11-06
HEBEI AGRICULTURAL UNIV.
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are no relevant research reports on the molecularly imprinted polymer-chemiluminescence method or kit for phenothiazine drugs at home and abroad.

Method used

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  • Molecularly imprinted polymer, chemiluminescence kit and detection method specific for phenothiazine drug family
  • Molecularly imprinted polymer, chemiluminescence kit and detection method specific for phenothiazine drug family
  • Molecularly imprinted polymer, chemiluminescence kit and detection method specific for phenothiazine drug family

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Molecularly imprinted polymer synthesis example 1

[0029] (a) 1 part of molecular template 2-trifluoromethylphenothiazine and 5 parts of functional monomer methacrylic acid were dissolved in a solvent, stirred and dissolved, and left to react for 10 hours;

[0030] (b) Add 30 parts of initiator azobisisobutyronitrile and 10 parts of crosslinking agent ethylene glycol dimethyl acrylate to the above reaction system, and shake for 10 hours;

[0031] (c) Put the solid particles obtained after the above reaction in a Soxhlet extractor, and continuously reflux with the extract for 12 hours to extract the imprinted template molecules. The extract used is a mixed solution of methanol and acetic acid, and methanol and The volume ratio of acetic acid is 9:1;

[0032] (d) drying the solid particles after the above reaction to obtain a phenothiazine drug family-specific molecularly imprinted polymer.

Embodiment 2

[0033] Example 2 Molecularly imprinted polymer synthesis example 2

[0034] (a) 1 part of molecular template 2-trifluoromethylphenothiazine and 7 parts of functional monomer methacrylic acid were dissolved in a solvent, stirred and dissolved, and left to react for 12 hours;

[0035] (b) Add 40 parts of initiator azobisisobutyronitrile and 20 parts of crosslinking agent ethylene glycol dimethyl acrylate to the above reaction system, and shake for 12 hours;

[0036] (c) Put the solid particles obtained after the above reaction in a Soxhlet extractor, and continuously reflux with the extract for 24 hours to extract the imprinted template molecules. The extract used is a mixed solution of methanol and acetic acid, and methanol and The volume ratio of acetic acid is 9:2;

[0037] (d) drying the solid particles after the above reaction to obtain a phenothiazine drug family-specific molecularly imprinted polymer.

Embodiment 3

[0038] Example 3 Molecularly imprinted polymer synthesis example 3

[0039] (a) 1 part of molecular template 2-trifluoromethylphenothiazine and 6 parts of functional monomer methacrylic acid were dissolved in a solvent, stirred and dissolved, and left to react for 11 hours;

[0040] (b) Add 35 parts of initiator azobisisobutyronitrile and 15 parts of crosslinking agent ethylene glycol dimethyl acrylate to the above reaction system, and shake for 11 hours;

[0041] (c) Put the solid particles obtained after the above reaction in a Soxhlet extractor, and continuously reflux with the extract for 18 hours to extract the imprinted template molecules. The extract used is a mixed solution of methanol and acetic acid, and methanol and The volume ratio of acetic acid is 9:0.5;

[0042] (d) drying the solid particles after the above reaction to obtain a phenothiazine drug family-specific molecularly imprinted polymer.

[0043] The scanning electron micrographs of the molecularly impri...

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Abstract

The invention discloses molecularly imprinted polymer with phenothiazine drug specificity, a chemiluminiscence kit and a detection method. The molecularly imprinted polymer is prepared by taking 2-trifluoromethyl phenothiazine as a molecular template, methacrylic acid as functional monomer, azodiisobutyronitrile as an initiator, and ethylene dimethacrylate as a crosslinking agent. The chemiluminiscence kit is prepared by taking a molecularly imprinted compound as a core reagent, imidazole as a catalyst, and bis (2, 4, 6-trichlorophenyl) oxalic ester and hydrogen peroxide as chemiluminescence reagents, and meanwhile the detection method adopting the kit is further provided. The molecularly imprinted polymer can capture various phenothiazine drugs, and the chemiluminiscence kit can accurately, rapidly and efficiently detect various phenothiazine drugs.

Description

technical field [0001] The invention relates to the field of animal food safety, in particular to a molecularly imprinted polymer capable of capturing four phenothiazine drugs, a chemiluminescence kit prepared therefrom, and a detection method using the kit. Background technique [0002] Phenothiazines are a class of sedatives that can be used to treat convulsions and mania in animals, or to administer drugs before anesthesia. Common varieties include chlorpromazine, promethazine, perphenazine, and acepromazine. When this type of medicine is added to animal feed as a feed additive, it can reduce the amount of activity of the animal, thereby improving the feed conversion rate and playing the role of fattening. However, such drugs are metabolized slowly and can remain in animals for 2-3 months, directly endangering the health of consumers. The Ministry of Agriculture of the People's Republic of China stipulates that the use of such products in animal feed and drinking water i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/06C08F222/14B01J20/26B01J20/30C08J9/26G01N21/76
CPCB01J20/268C08F220/06C08J9/26C08J2201/0424G01N21/76C08F222/102
Inventor 王建平夏婉秋王庚南
Owner HEBEI AGRICULTURAL UNIV.
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