Application of atractylenolide I in preparation of anti-hepatocarcinoma drugs

A technique of atractylide, anti-hepatocellular carcinoma, applied in the field of medicine, can solve the problem that there is no anti-hepatocellular carcinoma of Atractylidene I

Inactive Publication Date: 2018-09-04
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Atractylodes lactone Ⅰ is one of the active ingredients of Atractylodes macrocephala, which has the function of regulating gastrointestinal tract function and promoting the absorption of nutrients. So far, there is no report on the anti-liver cancer of Atractylodes lactone Ⅰ

Method used

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  • Application of atractylenolide I in preparation of anti-hepatocarcinoma drugs
  • Application of atractylenolide I in preparation of anti-hepatocarcinoma drugs
  • Application of atractylenolide I in preparation of anti-hepatocarcinoma drugs

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Embodiment Construction

[0012] The present invention will be further described below in conjunction with the examples. It should be noted that the following descriptions are only for explaining the present invention and not limiting its content.

[0013] 1. Test material

[0014] BALB / c nude mice, provided by the Animal Experiment Research Center of Zhejiang University of Traditional Chinese Medicine, experimental animal use license: SYXK (Zhejiang) 2013-0184; age: 4-5w; body weight: 18-22g; sex: female; number of animals : 30 pieces in total. Cyclophosphamide: produced by Jiangsu Hengrui Pharmaceutical Co., Ltd., batch number H32020857.

[0015] 2. Test method and content

[0016] 2.1 Animal grouping and modeling

[0017] Tumor model: Human liver cancer cell line HepG2 uses RPMI-164 culture medium containing 10% volume fraction of calf serum, and the tumor cell line is maintained at 37°C and 5% CO 2 Routine culture under experimental conditions, the cells grow in a single layer adherent, when th...

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Abstract

The invention discloses an application of atractylenolide I in the preparation of anti-hepatocarcinoma drugs. The cell experiment results show that atractylenolide I can induce apoptosis of hepatocarcinoma HepG2 cells, which is confirmed to induce apoptosis of human hepatocarcinoma cell lines. The animal experiment results show that atractylenolide I has a good anti-tumor effect on the human hepatocarcinoma HepG2 cell line.

Description

technical field [0001] The invention relates to a new application of medicine, in particular to the application of atractyloderm I in the preparation of anti-liver cancer medicine. It belongs to the field of medical technology. Background technique [0002] Primary hepatocellular carcinoma (hepatocellular carcinoma for short) is a type of cancer cells with extremely high malignancy and the worst prognosis. According to the statistics of the World Health Organization, there were about 745,500 liver cancer deaths worldwide in 2012, of which my country accounted for half of the global liver cancer deaths. Treatment methods include surgery, hepatic artery ligation, hepatic arterial chemoembolization, radiofrequency, cryotherapy, laser, chemotherapy and radiation therapy, etc., with relatively large side effects. Because most patients with liver cancer have hidden disease, long incubation period, no or no obvious symptoms in the early stage, and their aggressiveness and rapid d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P35/00A61P1/16
CPCA61K31/365A61P1/16A61P35/00
Inventor 曹岗张纪达
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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