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Callicarpa nudiflora extract composition for treating hand-foot-and-mouth disease and application thereof

A technology for Auranthus nudiflora and hand, foot and mouth disease, which is applied in the field of Auranthus nudiflora extract composition, can solve the problems of unclear active ingredients, poor controllability of quality standards, large dosage, etc., and achieve remarkable curative effect and stable quality , The effect of simple preparation method

Active Publication Date: 2018-08-17
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above-mentioned prior art, there are disadvantages such as large doses of the related preparations of nudibranchs, unclear active ingredients, and poor controllability of quality standards, which make it difficult to meet the requirements of "safe, effective, controllable, and stable" drugs.

Method used

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  • Callicarpa nudiflora extract composition for treating hand-foot-and-mouth disease and application thereof
  • Callicarpa nudiflora extract composition for treating hand-foot-and-mouth disease and application thereof
  • Callicarpa nudiflora extract composition for treating hand-foot-and-mouth disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 The extraction of total flavonoids, total phenolic acids and phenylethanol glycosides

[0046] (1) Preparation of the water extract of Auranthus nudiflora:

[0047] Add water to 100°C and extract 3 times, add 8 times of water each time, extract for 2.5 hours for the first time, and extract for 0.5 hours for the second and third times, combine the filtrates, filter, and concentrate under reduced pressure at 60°C to a relative density of 1.30-1.35 In the form of extract, dried at 60°C to dry extract, set aside;

[0048] (2) Preparation of total flavonoids from Auranthus nudica:

[0049] ① Dissolve the water extract of Aurora nudiflora in ethanol, and prepare a 0.5mg / mL ethanol solution of Aurora nudiflora;

[0050] ②The ethanol solution of Auranthus nudica was passed through AB-8 resin (the ratio of diameter to height was 1:15), 95% ethanol was used as eluent, the injection rate was 1.5mL / min, the elution rate was 20 drops / min, and the eluate was collected. D...

Embodiment 2

[0060] Example 2 The extraction of total flavonoids, total phenolic acids and phenylethanol glycosides

[0061] (1) Preparation of the water extract of Auranthus nudiflora:

[0062] Add water 105°C to extract 2 times, each time add 10 times of water, extract for 2 hours for the first time, extract for 1 hour for the second time, combine the filtrate, filter, concentrate under reduced pressure at 80°C to an extract with a relative density of 1.30-1.35 , dried at 70°C to form a dry extract, and set aside;

[0063] (2) Preparation of total flavonoids from Auranthus nudica:

[0064] ①The water extract of Aurora nudiflorum, dissolved in ethanol, is prepared as 0.8mg / mL ethanol solution of Aurora nudiflora;

[0065] ②The ethanol solution of Aurantia nudica is passed through AB-8 resin (the ratio of diameter to height is 1:10), 90% ethanol is used as the eluent, the injection rate is 2mL / min, the elution rate is 25 drops / min, and the eluted After the total flavonoid content of the...

Embodiment 3

[0075] Example 3 The extraction of total flavonoids, total phenolic acids and phenylethanol glycosides

[0076] (1) Preparation of the water extract of Auranthus nudiflora:

[0077] Add water to 110°C for extraction once, add 12 times of water each time, extract for 1 hour for the first time, extract for 3 hours for the second time, combine the filtrates, filter, concentrate under reduced pressure at 90°C to an extract with a relative density of 1.30-1.35 , dried at 75°C to form a dry extract, and set aside;

[0078] (2) Preparation of total flavonoids from Auranthus nudica:

[0079] ① Dissolve the water extract of Aurora nudiflora in ethanol, and prepare a 1 mg / mL ethanol solution of Aurora nudiflora;

[0080] ②The ethanol solution of Auranthus nudica is passed through AB-8 resin (the ratio of diameter to height is 1:8), 85% ethanol is used as the eluent, the injection rate is 3mL / min, the elution rate is 30 drops / min, and the eluted After the total flavonoid content of th...

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly provides a callicarpa nudiflora extract composition for treating a hand-foot-and-mouth disease. According to the parts by weight, the composition is prepared by 22-40 parts of total callicarpa nudiflora flavone, 20-26 parts of total callicarpa nudiflora phenolic acid, and 40-50 parts of total callicarpa nudifloraphenylethanoid glycosides. The invention further discloses an application of the composition. Three components used by the composition are extracted from callicarpa nudiflora, and the components of the composition are clear. Through the synergistic effect of each component, the composition has the good efficacy of treating and / or preventing the hand-foot-and-mouth disease.

Description

technical field [0001] The present invention relates to an extract composition and application thereof, in particular to an extract composition of Auranthus nudica with the effect of treating hand, foot and mouth disease and an application thereof. Background technique [0002] Hand, foot, and mouth disease (HFMD) is a common acute infectious disease in pediatrics, which often occurs in preschool children. The clinical manifestations are fever, sore throat, oral herpes, rash on hands and / or feet or other parts, herpes or small ulcers , can be cured in about 7 days. However, there are still some children with severe complications such as encephalitis and pulmonary edema. The main harm of hand, foot and mouth disease to young children and infants is the high mortality rate and high disability rate of severe and critical hand, foot and mouth disease. , especially HFMD patients with brainstem encephalitis, neurogenic pulmonary edema, and cardiorespiratory failure. HFMD is high...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P31/14
CPCA61K36/85A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P31/14A61K2300/00
Inventor 陈梁李小锋胡吉忠夏淑英吴木繁杨伟庆
Owner JIANGXI POZIN PHARMA
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