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Application of fraxin in preparation of drugs for preventing or treating acute respiratory distress syndrome

A technology for acute respiratory distress and qinpiside, which is applied in drug combinations, respiratory diseases, pharmaceutical formulations, etc., and can solve problems such as no specific treatment drugs, no qinpiside to prevent or treat acute respiratory distress syndrome, and secondary infections.

Inactive Publication Date: 2018-08-17
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no specific drug for the treatment of ARDS, and the main clinical treatment is mechanical ventilation support, which is used to improve the symptoms of respiratory distress and refractory hypoxemia in patients with ARDS
Although it plays an important role in the treatment of ARDS, there are also risks of secondary infection and ventilator-associated lung injury. Therefore, the development of effective drugs for the treatment of ARDS has always been a focus of attention and a difficulty in research.
At present, there is no relevant report on the prevention or treatment of acute respiratory distress syndrome by aziperidin

Method used

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  • Application of fraxin in preparation of drugs for preventing or treating acute respiratory distress syndrome
  • Application of fraxin in preparation of drugs for preventing or treating acute respiratory distress syndrome
  • Application of fraxin in preparation of drugs for preventing or treating acute respiratory distress syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1: Effects of arugeridin on pathological changes of lung tissue, pulmonary edema and pulmonary vascular permeability.

[0060] This example detects the effects of azeperidin on the pathological changes of lung tissue, pulmonary edema and pulmonary vascular permeability. In this example, an ARDS mouse injury model induced by extrapulmonary factors LPS was used.

[0061] 1. Materials

[0062] C57BL / 6 mice, male, weighing 18-20g, clean grade, were purchased from Shandong Jinan Pengyue Experimental Animal Breeding Co., Ltd. (product number: SCXK (Lu) 20140007 ), fed adaptively for 3 days (d ), during the administration period Drink water and eat freely.

[0063] Fraxin (Fraxin) with a purity of 98% was purchased from Chengdu Mansite Biotechnology Co., Ltd. (product number: A0405); lipopolysaccharide (LPS) and Evans blue (Evans blue) were purchased from sigma (product number: L2880, E2129) ).

[0064] 2. Method

[0065] 2.1 Establishment and grouping of ARDS mous...

Embodiment 2

[0075] Example 2: Effect of azeperidin on the content of inflammatory factors tumor necrosis factor-α (TNF-α) and interleukin (IL-1β, IL-6) in alveolar lavage fluid.

[0076] This example examines the effect of arugeridin on the content of inflammatory factors tumor necrosis factor-α (TNF-α) and interleukin (IL-1β, IL-6) in alveolar lavage fluid. In this example, LPS-induced ARDS Mouse injury model.

[0077] 1. Materials

[0078] C57BL / 6 mice, male, weighing 18-20g, clean grade, were purchased from Shandong Jinan Pengyue Experimental Animal Breeding Co., Ltd. (product number: SCXK (Lu) 20140007 ), fed adaptively for 3 days (d ), during the administration period Drink water and eat freely.

[0079] Fraxin (Fraxin) with a purity of 98% was purchased from Chengdu Mansite Biotechnology Co., Ltd. (product number: A0405); lipopolysaccharide (LPS) and Evans blue (Evans blue) were purchased from sigma company (product number: L2880, E2129 ) Kit Tumor necrosis factor (TNF-α) kit, in...

Embodiment 3

[0088] Example 3: Effects of arugeridin on the contents of oxidative damage indicators reactive oxygen species (ROS), superoxide dismutase (SOD) and malondialdehyde (MDA) in lung tissue.

[0089] This example examines the effects of arugeridin on the contents of reactive oxygen species (ROS), superoxide dismutase (SOD), and malondialdehyde (MDA) in lung tissue. In this example, the LPS-induced ARDS mouse injury model was used.

[0090] 1. Materials

[0091] C57BL / 6 mice, male, weighing 18-20g, clean grade, were purchased from Shandong Jinan Pengyue Experimental Animal Breeding Co., Ltd. (product number: SCXK (Lu) 20140007 ), fed adaptively for 3 days (d ), during the administration period Drink water and eat freely.

[0092] Fraxin (Fraxin) with a purity of 98% was purchased from Chengdu Mansite Biotechnology Co., Ltd. (product number: A0405); lipopolysaccharide (LPS), Evans blue (Evans blue), and 2′,7′-dichlorofluorescein diacetate were purchased from Purchased from Sigma C...

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PUM

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Abstract

The invention provides application of fraxin in preparation of drugs for preventing or treating an acute respiratory distress syndrome (ARDS). The fraxin is a coumarins compound which is extracted from dry barks of oleaceae fraxinus chinensis, Fraxinus szaboana Lingelsh or Fraxinus stylosa Lingelsh. Existing researches show that the fraxin has effects of resisting inflammation, reducing blood uricacid, resisting bacteria and inducing diuresis. On the basis of constructing an anima damage model of acute respiratory distress syndrome, by HE, Evan blue staining, fluorescence probes, immunofluorescent labeling, western blotting and the like, it verifies that the fraxin can reduce generation and releasing of reactive oxygen (ROS), inhibit generation and releasing of inflammatory factors and inhibit activation of signal paths MAPKs, therefore, degradation of a blood vessel endothelial polysaccharide coating is relieved, and vascular permeability is relieved to prevent or treat ARDS.

Description

technical field [0001] The present invention relates to a new medicine application of auretidin, in particular to the application of auretidin in the preparation of medicines for preventing or treating acute respiratory distress syndrome. Aziperidin reduces oxidative damage by inhibiting the production and release of reactive oxygen species (ROS) in acute respiratory distress syndrome; inhibits the production of inflammatory factors and the activation of key inflammatory regulatory signaling pathways, and relieves the inflammatory response; reduces the polysaccharide coating damage of vascular endothelial cells , Inhibit the increase of vascular permeability and pulmonary edema; and then inhibit the occurrence and development of ARDS, prevent or treat ARDS. Background technique [0002] Acute respiratory distress syndrome (ARDS) refers to severe infection, trauma, aspiration and other non-cardiogenic pathogenic factors inside and outside the lungs, characterized by diffuse d...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P11/00
CPCA61K31/7048A61P11/00
Inventor 刘向勇王晓芝马晓红张东黄丽娜
Owner BINZHOU MEDICAL COLLEGE
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