Preparation method and application of hyperbranched polyester based polyurethane medical adhesive

A technology of hyperbranched polyester and polyurethane, which can be used in applications, surgical adhesives, medical science, etc. It can solve the problems of general adhesion, easy infection, and difficulty in completely covering the bacterial invasion and infection of the wound surface, and the modulus can be adjusted. Large range, good biocompatibility, and comfortable and convenient implementation

Active Publication Date: 2018-08-07
广州迅合医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical sutures need to be operated by professional doctors, causing pain to patients when using them, difficult to repair microtrauma, and easy to cause infection
Medical adhesive tape has low adhesion strength, poor adaptability to complex wounds, and it is difficult to completely cover the wound, resulting in subsequent bacterial invasion and infection
Commercial bioglues mainly include fibrin glue, α-cyanoacrylate, etc. Fibrin glue has good biological safety, but its adhesion is general and expensive; although α-cyanoacrylate has fast curing speed and high strength, it has Certain biological toxicity, and will prevent wound healing, high modulus is brittle, difficult to adapt to the tissue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The first step is to pass N 2 , Under stirring, add 10gH101 (20mmol, 120mmol of -OH) into a round bottom flask, then slowly drop 3.17ml (40mmol) of acryloyl chloride and an equimolar amount of triethylamine into it, react for more than 24h, and separate and purify it. Precursor 1. The second step is to pass N 2 , Add 4.52gLDI (20mmol) into a round bottom flask under stirring environment, then slowly drop 2gPEG200 (10mmol) into it, and react at 60℃ for >12h to obtain precursor 2. The third step is to pass N 2 , Add 6.52g (10mmol, 20mmol of -NCO) precursor 2 into a round bottom flask under stirring, and then slowly drop 1.52g (2.5mmol, 10mmol of -OH) precursor 1 into it to obtain a Double bond hyperbranched polyester-based polyurethane medical adhesive. In the fourth step, the medical adhesive obtained in the third step is uniformly mixed with the 0.1 wt% photoinitiator i2595, and stored in the dark for use. When in use, apply the medical adhesive to the damaged tissue, ...

Embodiment 2

[0021] The first step is to pass N 2 , Add 12gH201 (20mmol, 120mmol of -OH) into a round bottom flask under stirring environment, then slowly drop 6.34ml (80mmol) of acryloyl chloride and an equimolar amount of triethylamine into it, react for more than 24h, and separate and purify it. Precursor 1. The second step is to pass N 2 , Add 4.52gLDI (20mmol) into a round bottom flask under stirring environment, then slowly drop 2gPEG200 (10mmol) into it, and react at 60℃ for >12h to obtain precursor 2. The third step is to pass N 2 , Add 3.586g (5.5mmol, 11mmol of -NCO) precursor 2 into a round bottom flask under stirring, and then slowly drop 1.52g (2.5mmol, 10mmol of -OH) precursor 1 into it to obtain a Hyperbranched polyester-based polyurethane medical adhesive containing double bonds. In the fourth step, the medical adhesive obtained in the third step is uniformly mixed with 0.5 wt% photoinitiator i2595, and stored in the dark for use. When in use, apply the medical adhesive to...

Embodiment 3

[0023] The first step is to pass N 2 , Add 18.4g of H301 (20mmol, 120mmol of -OH) into a round bottom flask under agitation, then slowly add 4.755ml (60mmol) of acryloyl chloride and an equimolar amount of triethylamine to it, react for more than 24h, separate and purify Get the precursor 1. The second step is to pass N 2 , Add 4.52gLDI (20mmol) into a round bottom flask under stirring environment, then slowly drop 2gPEG200 (10mmol) into it, and react at 60℃ for >12h to obtain precursor 2. The third step is to pass N 2 , Add 4.89g (7.5mmol, 15mmol of -NCO) precursor 2 into a round bottom flask under stirring, and then slowly drop 1.52g (2.5mmol, 10mmol of -OH) precursor 1 into it to obtain a Hyperbranched polyester-based polyurethane medical adhesive containing double bonds. In the fourth step, the medical adhesive obtained in the third step is uniformly mixed with the 0.2wt% photoinitiator i2595, and stored in the dark for use. When in use, apply the medical adhesive to the ...

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PUM

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Abstract

The invention discloses a preparation method and application of a hyperbranched polyester based polyurethane medical adhesive. The preparation method comprises the following steps: 1) taking hydroxyl-terminated hyperbranched polyester and acryloyl chloride to react, and obtaining a series of double-bond modified precursors 1 through a regulation and control ratio, wherein the mol ratio of -OH in the hydroxyl-terminated hyperbranched polyester to the acryloyl chloride is 1 to (2 to 4); 2) feeding diisocyanate and polyethylene glycol according to the mol ratio of 2 to 1 and reacting to obtain aprecursor 2; 3) taking the precursor 1 and the precursor 2 to react according to the ratio of a -OH functional group number of the precursor 1 to a -NCO functional group number of the precursor 2 of 1to (1.1 to 2.0), so as to obtain a double-bond-containing hyperbranched polyester based polyurethane medical adhesive; 4) uniformly mixing the hyperbranched polyester based polyurethane medical adhesive with 0.1 to 0.5 weight percent of photoinitiator i2595 and preserving in a dark place for later use. The medical adhesive prepared by the preparation method has no toxicity and harms, good biocompatibility and a strong chemical adhesive force on human tissues.

Description

Technical field [0001] The invention relates to the technical field of medical glue, in particular to a preparation method and application of a hyperbranched polyester-based polyurethane medical adhesive. Background technique [0002] Existing human tissue wound repair methods: surgical suture, medical tape and commercial biological glue. Surgical sutures need to be operated by professional doctors, which cause pain to the patient when used, are difficult to use for the repair of minimal wounds, and easily cause infection. Medical tape has low adhesive strength and poor adaptability to complex wounds, and it is difficult to completely cover the wounds, causing subsequent bacterial invasion and infection. Commercial bio-glue mainly includes fibrin glue, α-cyanoacrylate, etc. Fibrin glue has good biological safety, but the adhesion is general and expensive; although α-cyanoacrylate has fast curing speed and high strength, it has Certain biological toxicity, and will prevent wound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/68C08G18/48C08G63/91A61L24/00A61L24/04
CPCA61L24/001A61L24/046C08G18/48C08G18/68C08G63/91
Inventor 施雪涛宣承楷
Owner 广州迅合医疗科技有限公司
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