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Mesoporous bioactive glass/metal organic framework support material and preparation method thereof

A metal-organic framework and bioactive glass technology, applied in the field of materials science, can solve the problems of pH microenvironment regulation, inability to precisely control the internal structure of scaffold materials, and unsatisfactory biological activity, etc., and achieve the effect of high mechanical strength

Active Publication Date: 2018-08-03
HUANGGANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem of preparation of bone tissue engineering scaffold material, the present invention provides a mesoporous bioactive glass / metal organic framework composite scaffold material and its preparation method. The preparation method of this composite scaffold material solves the problems in the prior art The prepared bone tissue engineering scaffold material cannot precisely control the internal structure of the scaffold material, and the mechanical properties, pH microenvironment regulation and biological activity are not very ideal.

Method used

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  • Mesoporous bioactive glass/metal organic framework support material and preparation method thereof
  • Mesoporous bioactive glass/metal organic framework support material and preparation method thereof
  • Mesoporous bioactive glass/metal organic framework support material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0024] A method for preparing a mesoporous bioactive glass / metal organic framework composite scaffold material, comprising the following steps:

[0025] Step 1, preparing mesoporous bioactive glass / metal organic framework (MBG / MOF) composite printing ink. The MBG and MOF powders were mixed evenly at a mass ratio of 90:10, passed through a 400-mesh sieve, and then 0.7 g of the mixed powder was added to 2.0 ml of polycaprolactone (PCL) / chloroform solution (0.15 g / mL ), stir evenly, and then seal and store.

[0026] Step 2, using CAD / CAM computer-aided software to design the appearance and internal structure of the MBG / MOF composite scaffold material, the scaffold material model is a cylinder ( h=10mm), the internal pore diameter is 400 μm, and the included angle between two adjacent ink layers is 60°.

[0027] Step 3, low temperature 3D printing technology to prepare MBG / MOF composite scaffold material. Put the prepared printing ink into the barrel of the 3D printer, then in...

Embodiment 2

[0029] A method for preparing a mesoporous bioactive glass / metal organic framework composite scaffold material, comprising the following steps:

[0030] Step 1, preparing MBG / MOF composite printing ink. Mix the MBG and MOF powders in a mass ratio of 70:30, pass through a 400-mesh sieve, and then add 0.7 grams to 3.0 ml of polycaprolactone (PCL) / chloroform solution (0.1 g / mL) , stir evenly, and then seal and store.

[0031] Step 2, using computer-aided software such as CAD / CAM to design the appearance and internal structure of the MBG / MOF composite scaffold material, the scaffold material model is a cylinder ( h=10mm), the internal pore diameter is 300 μm, and the included angle between two adjacent ink layers is 60°.

[0032] Step 3, low temperature 3D printing technology to prepare MBG / MOF composite scaffold material. Put the prepared printing ink into the barrel of the 3D printer, then install a needle with a diameter of 300 microns, and pre-cool at 8°C for 15 minutes; r...

Embodiment 3

[0034] A method for preparing a mesoporous bioactive glass / metal organic framework composite scaffold material, comprising the following steps:

[0035] Step 1, preparing MBG / MOF composite printing ink. Mix the MBG and MOF powders in a mass ratio of 50:50, pass through a 300-mesh sieve, and then add 0.7 grams to 3.0 ml of polycaprolactone (PCL) / chloroform solution (0.1 g / ml) , stir evenly, and then seal and store.

[0036] Step 2, using CAD / CAM computer-aided software to design the appearance and internal structure of the MBG / MOF composite scaffold material, the scaffold material model is a cylinder ( h=10mm), the internal pore diameter is 200 μm, and the included angle between two adjacent ink layers is 90°.

[0037]Step 3, low temperature 3D printing technology to prepare MBG / MOF composite scaffold material. Put the prepared printing ink into the barrel of the 3D printer, then install a needle with a diameter of 200 microns, and pre-cool at 4°C for 15 minutes; run the 3D...

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Abstract

The invention discloses a mesoporous bioactive glass / metal organic framework support material and a preparation method of the material. The preparation method comprises the steps of preparing mesoporous bioactive glass / metal organic framework composite printing ink, designing an appearance and an internal structure of the support material via CAD / CAM (computer aided design / computer aided manufacturing) computer aided software, and preparing the mesoporous bioactive glass / metal organic framework composite support material via a low temperature 3D (three dimensional) printing technology. The prepared mesoporous bioactive glass / metal organic framework composite support material has a three-dimensional communicating and controllable macroporous structure, is high in mechanical strength and good in biocompatibility, can promote proliferation, differentiation and osteogenesis of bone marrow mesenchym stem cells of a human body and is expected to provide a new strategy for repairing treatmentof a large segmental bone defect clinically.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a bone tissue engineering support material, in particular to a mesoporous bioactive glass / metal organic framework composite support material. Background technique [0002] The repair and treatment of large bone defects caused by bone tumors and traffic accidents is a huge clinical challenge. At present, the use of bone tissue engineering scaffold materials to repair and treat bone defects is considered to be one of the effective methods to solve related problems. Generally, bone tissue engineering scaffold materials need to have basic requirements such as a three-dimensional interconnected porous structure, good mechanical support performance, biodegradability and biological activity. Therefore, the design and preparation of bone tissue engineering scaffold materials that meet the above basic requirements is a key issue in the repair and treatment of bone defects. [0003] Mesopo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/18A61L27/50A61L27/56A61L27/58B33Y10/00B33Y50/02B33Y70/00B33Y80/00
CPCA61L27/10A61L27/18A61L27/50A61L27/56A61L27/58A61L2430/02B33Y10/00B33Y50/02B33Y70/00B33Y80/00C08L67/04
Inventor 朱钰方田正芳陈砚美阮志军
Owner HUANGGANG NORMAL UNIV
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