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N,N-dimethylglycine organic acid compound salt and composition and application thereof

A technology of dimethyl glycine and dimethyl glycine root is applied in the application field of preparing animal feed additives, which can solve the problems of mildew and deterioration of products, caking of products, failure to meet application requirements of the feed processing industry, etc. The effect of production costs

Active Publication Date: 2018-07-31
GUANGZHOU INSIGHER BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, N,N-dimethylglycine is a strong hygroscopic solid, which is inconvenient to store and use
Commonly used N,N-dimethylglycine hydrochloride, N,N-dimethylglycine sodium, N,N-dimethylglycine potassium, etc. are also very hygroscopic, and are easy to absorb moisture and deliquescence during storage. In product processing, the requirements for production equipment and plant facilities are high, otherwise it will lead to product agglomeration due to moisture absorption during the production process, which cannot meet the application requirements of the feed processing industry
In addition, the packaging of products containing DMG or DMG hydrochloride or alkali metal salts must be tightly sealed. Once the seal is not enough, the product will be moldy and deteriorated due to moisture absorption during storage.

Method used

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  • N,N-dimethylglycine organic acid compound salt and composition and application thereof
  • N,N-dimethylglycine organic acid compound salt and composition and application thereof
  • N,N-dimethylglycine organic acid compound salt and composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Example 1 N,N-Dimethylglycine Calcium Benzoate, the chemical structural formula is as follows:

[0113]

[0114] Add 28.00g (200.60mmol, 1.00eq) of N,N-dimethylglycine hydrochloride (DMG hydrochloride for short), 350mL of absolute ethanol, and stir vigorously at room temperature to form a uniform suspension in a 1L three-necked reaction flask; Add solid sodium hydroxide 8.2g (1g×8, 205.0mmol, 1.02eq) to the reaction system in batches, exothermic, and stir at room temperature for 0.5h; add 25.0g (204.7mmol, 1.02eq) needle-like crystalline solid benzoic acid to the reaction system ), stir vigorously at room temperature to make the reaction solution evenly dispersed; 15.0g (202.45mmol, 1.01eq) of powdered calcium hydroxide was put into the reaction system and stirred for 1h to obtain a white viscous reaction solution; 80mL of absolute ethanol was added to the reaction system, vigorously Stir the reaction for 3 hours to obtain a white suspension, filtered under reduced pressur...

Embodiment 2

[0116] Example 2 N,N-Dimethylglycine calcium sulfate, chemical formula and structural formula are as follows:

[0117]

[0118] Add 28.00g (200.60mmol, 1.00eq) of DMG hydrochloride to 300mL of absolute ethanol, stir vigorously at room temperature to form a uniform suspension; add solid sodium hydroxide 8.2g (1g×8, 205.0mmol) to the reaction system in batches , 1.02eq), exothermic, stirring at room temperature for 0.5h; the reaction solution was cooled to -20°C, and concentrated sulfuric acid 9.84g (100.30mmol, 0.50eq) was slowly added dropwise under vigorous stirring. After dripping, the reaction solution was warmed to room temperature and then added powder 15.0g (202.45mmol, 1.01eq) of calcium hydroxide was stirred and reacted for 1h to obtain a milky viscous reaction liquid; 80mL of absolute ethanol was added to the reaction system, and the reaction was vigorously stirred for 3h to obtain a white suspension. Filter under reduced pressure and filter residue After washing with ab...

Embodiment 3

[0119] Example 3 N, N-dimethyl glycine calcium phosphate, chemical formula and structural formula are as follows:

[0120]

[0121] Add 28.00g (200.60mmol, 1.00eq) of DMG hydrochloride to 300mL of absolute ethanol, add solid NaOH 8.02g (200.60mmol, 1.00eq) under vigorous stirring, exotherm violently, slowly add 85% phosphoric acid 7.86 dropwise at room temperature g(68.20mmol, 0.34eq), add solid Ca(OH) to the reaction solution after dropping 2 15.00g (202.45mmol, 1.00eq), the reaction solution was stirred at room temperature for 1 hour to obtain an emulsion. Add 100 mL of absolute ethanol to the emulsion reaction solution, and continue to stir and react for 3 hours. The reaction solution was filtered under reduced pressure to obtain the filter residue as a white solid. The filter residue was washed with absolute ethanol (50 mL×3) and dried under vacuum at 50° C. overnight to obtain the product as a white solid. The yield was 27.58 g and the yield was 77.53%.

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PUM

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Abstract

The invention discloses a N,N-dimethylglycine organic acid polyvalent metal ion compound salt, and a solvate thereof, and application thereof in manufacturing of novel feed additive, and application in manufacturing of feed. The invention also discloses a feeding composition including the N,N-dimethylglycine organic acid polyvalent metal ion compound salt or the solvate thereof. Applying the N,N-dimethylglycine organic acid polyvalent metal ion compound salt or the solvate in animal farming industry has effects of improving animal weight gain rate, reducing feed conversion ratio and other animal production performance, and the N,N-dimethylglycine organic acid polyvalent metal ion compound salt has similar or better effect than that of N,N-dimethylglycine sodium salt.

Description

Technical field: [0001] The invention belongs to the field of animal feed additives, and specifically relates to N,N-dimethylglycine complex salt or its solvate and a composition containing the foregoing salt and their application in preparing animal feed additives. Background technique: [0002] Dimethylglycine (DMG), the molecular formula is (CH 3 ) 2 NCH 2 COOH, white crystal in appearance, soluble in water and ethanol, is a physiologically active nutrient that naturally exists in food, grains, beans, and liver, and is a natural substance in the metabolic pathways of animals and plants. As a nutritional antioxidant additive, dimethylglycine also shows important physiological and biochemical functions in the health of humans and animals. A large number of animal experiments have found that dimethylglycic acid is a very safe food nutritional additive. [0003] However, N,N-dimethylglycine is a strong hygroscopic solid, which is inconvenient to store and use. Commonly used N,N-di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/12C07C63/08C07C57/15C07C53/126C07C309/30A23K20/111A23K20/105A23K10/30A23K10/37A23K20/28A23K20/24A23K20/163A23K20/147A23K20/26A23K20/20A23K20/174A23K20/142
CPCA23K10/30A23K10/37A23K20/105A23K20/111A23K20/142A23K20/147A23K20/163A23K20/174A23K20/24A23K20/26A23K20/28A23K20/30C07C53/126C07C57/15C07C63/08C07C229/12C07C309/30C07C229/76A23K20/10Y02P60/87
Inventor 彭险峰
Owner GUANGZHOU INSIGHER BIOTECHNOLOGY CO LTD
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