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Nicotine-zinc oxide complex, method for preparing same and tobacco product with nicotine-zinc oxide complex

A technology of tobacco products and compounds, which is applied in the fields of tobacco, processed tobacco, smoker’s products, etc. It can solve the problems of gastrointestinal or respiratory tract irritation, excessive nicotine release, physical discomfort, etc., and achieve good product stability Effect

Active Publication Date: 2018-07-27
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These new tobacco products either use tobacco as the direct raw material or add nicotine directly, which will cause the nicotine to be released too fast and too violently when the product is consumed. Or respiratory irritation, causing physical discomfort

Method used

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  • Nicotine-zinc oxide complex, method for preparing same and tobacco product with nicotine-zinc oxide complex
  • Nicotine-zinc oxide complex, method for preparing same and tobacco product with nicotine-zinc oxide complex
  • Nicotine-zinc oxide complex, method for preparing same and tobacco product with nicotine-zinc oxide complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0034] 1. Preparation of nicotine-zinc oxide complex

[0035] Accurately weigh 1.5 g of zinc sulfate solid, add distilled water, and ultrasonically dissolve the solid completely. Then add 7.5mL of distilled water, sonicate until completely dissolved, then add 0.2mL of nicotine dropwise to convert zinc (II) into zinc oxide. After the reaction, it was freeze-dried to obtain a white powder product. Determined by ultraviolet absorption spectrometry, it contains about 15% nicotine, which means that nicotine can interact with Zn 2+ The role thus exists in the Zn 2+ Formed zinc oxide precipitates.

[0036] 2. Structural characterization of nicotine-zinc oxide complex

[0037] 2.1 Powder X-ray Diffraction (XRPD)

[0038] The measurement conditions are: one-dimensional detection system X'Pert-PRO super energy detector, CuK α Radiation, IK α2 :IK α1 =0.5,λ 1 = 1.540598, λ 2 =1.544426, the light tube voltage is 40kV, the tube current is 40mA, the 2θ scanning range is 4-80°, the...

Embodiment 2

[0050] 1. Preparation of gum-based chewing tobacco containing nicotine-zinc oxide complex

[0051] a. Take microcrystalline paraffin 30%, acesulfame potassium 56%, propylene glycol 1%, glycerin 1%, lemon flavor 1%, Yunnan olive extract flavor 4%, red yeast rice 3%, nicotine-zinc oxide complex 4 %;

[0052] b. Baking the gum base first, mixing the materials evenly, stirring at 60°C for 60 minutes, forming, extruding, roller rolling, cutting, aging, and subpackaging is the finished product.

[0053] 2. Nicotine dissolution test in vitro

[0054] The product prepared in step 1, the gum-based chewing tobacco containing pure nicotine, and the gum-based chewing tobacco containing shredded tobacco were respectively subjected to nicotine dissolution test in vitro.

[0055] The present invention utilizes an oral cavity simulated chewing instrument to perform in vitro dissolution tests of nicotine on the above three gum-based chewing tobacco products.

[0056] Test method: Add the ar...

Embodiment 3

[0064] 1. Preparation of pouched snus containing nicotine-zinc oxide compound

[0065] a. Take 48% of microcrystalline cellulose, 5% of lemon flavor, 5% of propylene glycol, and 15% of nicotine-zinc oxide complex;

[0066] b. After mixing and sieving the materials, take 20-mesh powder and mix evenly. After baking and heat treatment in a pasteurizer, add water 13%, sodium chloride 3%, sodium carbonate 1%, vitamin A1 %, evenly blended, refrigerated for 12 hours, sprayed with 4% honey, 4% glucose, 1% aspartame, sealed and refrigerated for 24 hours, sterilized by ultraviolet light for 3 hours, and then packaged to obtain the finished product.

[0067] 2. Nicotine dissolution test in vitro

[0068] The product prepared in step 1, the bagged snus containing pure nicotine, and the bagged snus containing shredded tobacco were respectively subjected to nicotine dissolution test in vitro.

[0069] The present invention utilizes an oral cavity simulated chewing instrument to perform in...

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Abstract

The invention discloses a nicotine-zinc oxide complex. Characteristic peaks are available at locations with 2-theta angles of 12.49 degrees, 16.57 degrees, 18.73 degrees, 20.13 degrees, 22.07 degrees,22.80 degrees, 26.46 degrees, 35.81 degrees and 37.32 degrees of X-ray powder diffraction diagrams of the nicotine-zinc oxide complex. The invention further discloses a method for preparing the nicotine-zinc oxide complex and a tobacco product with the nicotine-zinc oxide complex. The method includes steps of a, adding inorganic acid and zinc oxide into solvents at the room temperature and completely dissolving the inorganic acid, the zinc oxide and the solvents by means of ultrasonic treatment; b, dropwise adding nicotine into products obtained at the step a; c, carrying out freeze-drying after reaction is completely carried out at the step b so as to obtain white powdery solid which is the nicotine-zinc oxide complex. The tobacco product can be a gum-based chewing tobacco, a mouth tobacco in bags, electronic cigarette liquid or a heating incombustible cigarette. The nicotine-zinc oxide complex, the method and the tobacco product have the advantages that the nicotine and zinc are bound with each other by the aid of salt forming modes, accordingly, the nicotine-zinc oxide complex can be formed, and obvious sustained-release effects are realized in artificial simulated saliva.

Description

technical field [0001] The invention belongs to the field of preparation of inorganic composites, and in particular relates to a nicotine-zinc oxide composite, a preparation method thereof and a tobacco product containing the same. Background technique [0002] Nicotine is the main chemical component of natural alkaloids in tobacco leaves. The molecular structure is composed of two nitrogen heterocycles, the pyrrole ring pKa=7.87, and the pyridine ring pKa=3.15. Due to the influence of aromatization, the nitrogen atom in the pyridine ring has a weak basicity, which is similar to that of aromatic amines. The nitrogen atom in the pyrrolidine ring belongs to a tertiary amine. Since the ring is not aromatic, its basicity is similar to that of an aliphatic tertiary amine, so nicotine is easy to chemically react with an acid. Rose, J.E., et al., Pulmonary delivery of nicotine pyruvate: Sensory and pharmacokinetic characteristics. Experimental and Clinical Psychopharmacology, 2010...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24B15/16A24B15/18A24B13/00A24F47/00
CPCA24F47/008A24B13/00A24B15/16A24B15/18
Inventor 杨继杨柳陈永宽段沅杏赵伟赵杨巩效伟韩熠王程娅李志强李寿波缪明明
Owner CHINA TOBACCO YUNNAN IND
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