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Construction method and applications of polycystic ovary animal model

A polycystic ovary and animal model technology, applied in the field of polycystic ovary animal model construction, can solve the problems of low success rate of polycystic ovary animal model, low degree of conformity of pathological features, strong randomness, etc. High compliance and weight-relieving effect

Inactive Publication Date: 2018-07-24
THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
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Problems solved by technology

[0006] The present invention aims to solve the problem of low success rate and strong randomness in the construction of polycystic ovary animal models in the prior art, and the low coincidence degree between the constructed polycystic ovary animal models and the clinical pathological characteristics of polycystic ovary syndrome; The construction method and application of the polycystic ovary animal model have realized the high-efficiency construction of the polycystic ovary animal model, and the constructed animal model is highly consistent with the clinical polycystic ovary pathological characteristics, which is convenient for further drug development

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  • Construction method and applications of polycystic ovary animal model
  • Construction method and applications of polycystic ovary animal model
  • Construction method and applications of polycystic ovary animal model

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Embodiment Construction

[0029] The present invention will be further described in detail below in conjunction with examples, but the embodiments of the present invention are not limited thereto.

[0030] A method for constructing a polycystic ovary animal model, comprising the following steps:

[0031] Step 1: Screen the test animals with normal follicles, place the test animals in the experimental space and mark them from 1 to N; specifically, the test animals with the first normal follicles are marked as 1; the test animals with the second normal follicles are marked is 2, and so on, the test animal whose Nth follicle is normal is marked as N.

[0032] Among them, normal follicles are ≥ 12 follicles with a diameter of 2-9 mm in one or both ovaries according to ultrasound standards and / or ovarian volume ≥ 10 ml.

[0033] Step 2: Detect the body weight, androgen level and blood sugar tolerance level of each experimental animal, and record them as Wt1, AI1, Glu1, Wt2, AI2, Glu2, Wt3, AI3, Glu3, Wt4, ...

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Abstract

The invention discloses a construction method and applications of a polycystic ovary animal model, and belongs to the technical field of animal models. A letrozole sustained release agent is embeddedin subcutaneous tissues of an animal for a test to simulate the symptoms of polycystic ovarian syndrome so as to establish a polycystic ovary animal model. The pathological characteristics of the polycystic ovary animal model are highly similar with those of polycystic ovarian syndrome; and further drug development is assisted by the animal model. At the same time, the influence of the inflammation environment and androgen environment of polycystic ovarian syndrome on the secretion of inflammation factors and the influence of the inflammation environment on fat tissues are studied.

Description

technical field [0001] The invention relates to an animal model, in particular to a construction method and application of a polycystic ovary animal model. Background technique [0002] Polycystic ovary syndrome (PCOS) is a common endocrine disease that causes infertility in women of reproductive age. Its pathological features are diverse and heterogeneous, including oligomenorrhea or amenorrhea, chronic anovulation, infertility, hirsutism, and acne. At the same time, it is often accompanied by symptoms such as obesity, hyperandrogenemia, hyperinsulinemia, and chronic inflammation. [0003] A good animal model is essential to study the pathogenesis of PCOS. A number of PCO animal models have been established at home and abroad, including androgen induction, estrogen induction, insulin combined with gonadotropin induction, and aromatase inhibitor induction. [0004] The State Intellectual Property Office published the application number CN201410696583.6 on June 08, 2016, wh...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4196A01K67/02A61K49/00
CPCA01K67/02A01K2207/20A01K2267/03A01K2267/0368A61K9/0019A61K31/4196A61K49/0008
Inventor 秦朗左涛许文明谢义东邱珂
Owner THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
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