Method and system for producing D-phenylalanine

Abstract

The invention discloses a method and a system for producing D-phenylalanine. The method comprises the following steps: adding water to dissolve a D-phenylalanine and D-tartaric acid double salt, adding ammonia water to adjust the pH value to the isoelectric point of D-phenylalanine, adding the obtained solution into the raw water chamber of an electrodialysis device, introducing the aqueous solution of D-phenylalanine in the raw water chamber into a first concentrating crystallization kettle when the electric conductivity is about zero, performing concentrating crystallization, centrifuging and drying to obtain D-phenylalanine, introducing D-tartrate ions in a cathode concentrating chamber into a second concentrating crystallization kettle, performing concentrating crystallization and centrifuging to obtain D-tartaric acid, and returning the obtained D-tartaric acid into a second reaction vessel for reuse. Existing methods and systems are improved, and the electrodialysis device is used to separate the obtained double salt in order to obtain the D-phenylalanine, so the method and the system have the advantages of simplicity and easiness in operation, time saving, high yield reaching 85-90%, no use of methanol or triethylamine, low cost and environmental protection.

Description

technical field [0001] The invention relates to a process and system for producing D-phenylalanine. Background technique [0002] D-phenylalanine is an important chiral amino acid, which is widely used in the fields of medicine and chemical industry. For example, D-phenylalanine is the raw material of anti-diabetic drug nateglinide, anti-tumor drug octreotide, and anti-AIDS drug indinavir. It can also be used as a chiral reagent or chiral sex intermediate. In addition, D-phenylalanine can also be used directly as a drug, such as an anti-stress agent, a preparation for controlling diabetes, an anti-inflammatory analgesic, etc., and can also be used as a chiral reagent or a chiral intermediate. [0003] There are many reports about the preparation method of D-phenylalanine. At present, the asymmetric conversion of L-phenylalanine that is mainly adopted in the industry prepares D-phenylalanine. Its process system includes the first reaction kettle connected successively, The...

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Problems solved by technology

[0003] There are many reports about the preparation method of D-phenylalanine. At present, the asymmetric conversion of L-phenylalanine that is mainly adopted in the industry prepares D-phenylalanine. Its process system includes the first reaction kettle connected successively, The first centrifuge, the first conveyor, the second reactor, the second centrifuge, the second conveyor, the third reactor, suction filtration device and concentrated crystallization kettle, when utilizing its process system for production, the L- Phenylalanine, catalyst salicylaldehyde and solvent acetic acid are added to the first reaction kettle, and the resulting reactants are sent to the second reaction kettle, and D-tartaric acid is added to the second reaction kettle. After the reaction is completed, it is concentrated and crystallized The isolated DL-phenylalanine is sent to the second reaction kettle, and D-tartaric acid is added in the second reaction kettle. After the reaction is completed, the D-phenylalanine·D-tartrate double salt is obtained through concentration and crystallization separation; -Phenylalanine·D-tartrate double salt is sent into the third reaction kettle, then triethylamine and methanol are added into the third reaction kettle for dissociation, after stirring for 1-2h, the D-tartaric acid and triethylamine The generated salt is precipitated because it is insoluble in methanol. After being filtered and removed by a suction filtration device, the obtained filtrate is concentrated and crystallized in a concentrated crystallization kettle to obtain D-tartaric acid. The triethylamine that needs to be used in this process is expensive and expensive. In addition, a large amount of solvent methanol must be used, which is not environmentally friendly.

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