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Glucosamine chlorogenate as well as preparation method and application thereof

A technology of glucosamine hydrochloride and glucosamine, which is applied in the field of daily chemicals, can solve problems such as unresearched organic salts of glucosamine, and achieve the effects of easy availability of equipment and raw materials, strong antioxidant activity and low cost

Active Publication Date: 2018-07-13
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is no research on the preparation of glucosamine organic acid salt

Method used

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  • Glucosamine chlorogenate as well as preparation method and application thereof
  • Glucosamine chlorogenate as well as preparation method and application thereof
  • Glucosamine chlorogenate as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] 1) Preparation of glucosamine solution: Weigh 6g of 50% sodium methoxide and add it into 60mL of anhydrous methanol to dissolve. Weigh 12g of glucosamine hydrochloride and add to the above system. Stir at room temperature for 5 min, and then centrifuge at 3000 r / min for 10 min. Remove the supernatant from the centrifuge tube for use;

[0026] 2) Preparation of glucosamine chlorogenic acid salt: add 19.7 g of chlorogenic acid in batches to the glucosamine solution, react at 0°C for 1 h, add 100 mL of acetone to precipitate, then stir at room temperature for 0.5 h, pump After filtration, the resulting solid was repeatedly washed with acetone and freeze-dried to obtain the glucosamine chlorogenic acid salt.

Embodiment 2

[0028] The difference from Example 1 is:

[0029] 1) Preparation of glucosamine solution: Weigh 4.8g of 50% sodium methoxide and add it into 60mL of anhydrous methanol to dissolve. Weigh 12g of glucosamine hydrochloride and add to the above system. Stir at room temperature for 10 min, and then centrifuge at 2800 r / min for 10 min. Remove the supernatant from the centrifuge tube for use;

[0030] 2) Preparation of glucosamine chlorogenic acid salt: add 19.7 g of chlorogenic acid in batches to the glucosamine solution, react at 0°C for 2 h, add 100 mL of acetone to precipitate, stir at room temperature for 1 h, and filter with suction , the obtained solid is repeatedly washed with acetone and freeze-dried to obtain the glucosamine chlorogenic acid salt.

Embodiment 3

[0032] The difference from Example 1 is:

[0033] 1) Preparation of glucosamine solution: Weigh 6g of 50% sodium methoxide and add it into 70mL of anhydrous methanol to dissolve. Weigh 12g of glucosamine hydrochloride and add to the above system. Stir at room temperature for 10 min, then centrifuge at 3000 r / min for 10 min. Remove the supernatant from the centrifuge tube for use;

[0034] 2) Preparation of glucosamine chlorogenic acid salt: add 39.5 g of chlorogenic acid in batches to the glucosamine solution, react at 0°C for 2 hours, add 100 mL of acetone to precipitate, stir at room temperature for 1 hour, and filter with suction , the obtained solid is repeatedly washed with acetone and freeze-dried to obtain the glucosamine chlorogenic acid salt.

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PUM

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Abstract

The invention discloses glucosamine chlorogenate as well as a preparation method and application thereof. The preparation method comprises the following steps of by taking glucosamine hydrochloride, sodium methoxide and chlorogenic acid as raw materials, performing neutralisation and desalination on the glucosamine hydrochloride with a sodium methoxide alkaline solution to obtain a glucosamine solution, and performing reaction on the glucosamine solution and the chlorogenic acid to obtain the glucosamine chlorogenate. The prepared glucosamine chlorogenate is greatly improved in the biologicalactivity such as antioxidant activity, available in preparation raw materials, simple to prepare and mild in condition, can be developed into an antioxidant, can be widely used for the field of biology, medicines, foods, chemical engineering and the like and lays a foundation of further application and development of the glucosamine.

Description

technical field [0001] The invention relates to the field of daily chemicals, in particular to a chlorogenic acid salt of glucosamine and its preparation method and application. Background technique [0002] Glucosamine compounds are a class of specific drugs for the treatment of osteoarthritis, and are also important components necessary for the synthesis of amino polysaccharides in the human articular cartilage matrix. At present, the reported glucosamine compounds are almost all in the form of glucosamine inorganic acid salts, mainly including its hydrochloride, sulfate, and compound salts containing metal elements such as magnesium and calcium. Among them, glucosamine hydrochloride is mainly obtained by degrading chitin under hydrochloric acid and high temperature conditions; the preparation of glucosamine sulfate is obtained by degrading chitin through sulfuric acid, and one method is through glucosamine hydrochloride obtained by salt substitution. The preparation of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H5/06C07H1/00A61P39/06
CPCC07H1/00C07H5/06
Inventor 郭占勇秦荣基谭文强秦荣珍董方姜峰
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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