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Preparation method of stable-hygroscopicity tissue adhesive material

An adhesive and stable technology, which is applied in the field of preparation of hygroscopic stable tissue adhesive materials, can solve the problems of poor adhesiveness and ineffective bonding of the adhesive, and achieves improvement in the decrease of adhesive performance and the improvement of hygroscopic stability. Performance, effect of good hygroscopic and moisturizing properties

Inactive Publication Date: 2018-06-15
CHANGZHOU LANXU CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: Aiming at the problem that the existing tissue adhesive material has poor adhesive viscosity and cannot be effectively bonded in a wet environment, a preparation of a moisture-absorbing stable tissue adhesive material is provided method

Method used

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  • Preparation method of stable-hygroscopicity tissue adhesive material

Examples

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example 1

[0018] Take the mangosteen fruit, remove the shell and core, and vacuum freeze-dry to a moisture content of 5%, ball mill and grind through a 100-mesh sieve to obtain a dry powder, and add the dry powder to an 85% ethanol solution in a mass ratio of 1:10 in water bath at 65-75°C for 2-3 hours, let it cool down to room temperature and filter to obtain a filter cake. According to the mass ratio of 1:10, stir and mix the filter cake with deionized water and place it under 250-300W Ultrasonic-assisted extraction for 3-5 hours, control the extraction temperature at 75-85°C, let it cool down to room temperature and filter to obtain the filtrate, add 5% ethanol dropwise to the filtrate at a volume ratio of 1:5, and let it stand for 6 After ~8h, centrifuge at 1500~2000r / min for 10~15min, collect the lower sediment and vacuum freeze-dry to obtain modified particles. In parts by weight, weigh 45~50 parts of deionized water, 13~ 15 parts of rubber viscose fiber, 10-15 parts of modified p...

example 2

[0020] Take the mangosteen fruit, remove the shell and core, and vacuum freeze-dry to a moisture content of 5%, ball mill and grind through a 100-mesh sieve to obtain a dry powder, and add the dry powder to an 85% ethanol solution in a mass ratio of 1:10 in water bath at 65-75°C for 2-3 hours, let it cool down to room temperature and filter to obtain a filter cake. According to the mass ratio of 1:10, stir and mix the filter cake with deionized water and place it under 250-300W Ultrasonic-assisted extraction for 3-5 hours, control the extraction temperature at 75-85°C, let it cool down to room temperature and filter to obtain the filtrate, add 5% ethanol dropwise to the filtrate at a volume ratio of 1:5, and let it stand for 6 After ~8h, centrifuge at 1500~2000r / min for 10~15min, collect the lower sediment and vacuum freeze-dry to obtain modified particles. In parts by weight, weigh 45~50 parts of deionized water, 13~ 15 parts of rubber viscose fiber, 10-15 parts of modified p...

example 3

[0022] Take the mangosteen fruit, remove the shell and core, and vacuum freeze-dry to a moisture content of 5%, ball mill and grind through a 100-mesh sieve to obtain a dry powder, and add the dry powder to an 85% ethanol solution in a mass ratio of 1:10 in water bath at 65-75°C for 2-3 hours, let it cool down to room temperature and filter to obtain a filter cake. According to the mass ratio of 1:10, stir and mix the filter cake with deionized water and place it under 250-300W Ultrasonic-assisted extraction for 3-5 hours, control the extraction temperature at 75-85°C, let it cool down to room temperature and filter to obtain the filtrate, add 5% ethanol dropwise to the filtrate at a volume ratio of 1:5, and let it stand for 6 After ~8h, centrifuge at 1500~2000r / min for 10~15min, collect the lower sediment and vacuum freeze-dry to obtain modified particles. In parts by weight, weigh 45~50 parts of deionized water, 13~ 15 parts of rubber viscose fiber, 10-15 parts of modified p...

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Abstract

The invention relates to a preparation method of a stable-hygroscopicity tissue adhesive material, and belongs to the technical field of medical materials. Mangosteen extraction and mangosteen polysaccharide collection are performed, and the molecular structure of the mangosteen polysaccharides is rich in hydroxyl groups or carboxyl groups and other polar groups, so the mangosteen polysaccharidesand water molecules can form hydrogen bonds and are mutually crosslinked to form a network structure in order to achieve good hygroscopicity and moisturizing properties; and banana adhesive fibers areeffectively coated and modified with the mangosteen polysaccharides, and a material is filled with the modified banana adhesive fibers to effectively improve the moisture resistance of the adhesive material and effectively improve the hygroscopicity stability of the adhesive. The stable-hygroscopicity tissue adhesive material forms a hydrogel after being oxidized and cross-linked, the gel polymerizes and swells after absorbing moisture, and the defect of water absorption induced adhesion decrease of the material is effectively overcome; and the stable-hygroscopicity tissue adhesive material has excellent biocompatibility, so the prepared hydrogel can be easily gelatinized and healed, so the adhesion of the adhesive in organisms is effectively promoted.

Description

technical field [0001] The invention relates to a preparation method of a hygroscopic stable tissue adhesive material, which belongs to the technical field of medical materials. Background technique [0002] With the development of modern medical science and technology, the requirements for clinical postoperative recovery effect are getting higher and higher. During the operation process, while minimizing pain and achieving rapid recovery, it is also hoped that the appearance can be restored to the greatest extent. Currently, there are several types of commercially available tissue adhesives, traditionally divided into three categories: natural and biological adhesives, synthetic and semi-synthetic adhesives, and biomimetic adhesives. When medical sutures are used in clinical practice, various complications are usually caused by leakage of body fluids, which may endanger the lives of patients in severe cases. However, there are still many deficiencies in the traditional me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/04A61L24/08
CPCA61L24/04A61L24/0005A61L24/0031A61L24/08C08L5/08C08L5/00
Inventor 汪巍蒋益
Owner CHANGZHOU LANXU CHEM CO LTD
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