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A traditional Chinese medicine composition for preventing and treating cardiorenal syndrome
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A technique for cardio-renal syndrome and composition, applied in the field of preparation of the traditional Chinese medicine composition, can solve the problem of not recommending long-term use and the like, and achieve the effects of no toxic and side effects, improved quality of life, and remarkable therapeutic effect
Active Publication Date: 2021-04-23
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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At present, among these drugs, diuretics require special monitoring of adverse reactions during use, and long-term use is not recommended clinically; there is currently no large-scale clinical data on the application of receptor blockers in chronic heart failure with consistent renal function; Renin-angiotensin-aldosterone system antagonists are often avoided clinically due to concerns about exacerbating renal function deterioration
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[0028] Use experimental data to show that the Chinese medicine composition of the present invention prevents and treats cardiorenal syndrome in vivo
[0029] 1. Test drug
[0030] Weigh the 7-day amount of the crude drug in proportion, add 18 times the amount of 50% ethanol to reflux and extract 3 times, each time for 1.5 hours. Filter, combine the extracts, and concentrate under reduced pressure to the equivalent of 1 g crude drug per ml.
[0031] 2. Experimental animals
[0032] Wiatar rats, male (200-250g), provided by Shanghai Lingchang Biotechnology Co., Ltd. (SCXK (Shanghai) 2013-0018).
[0033] 3. Experimental method
[0034] 3.1 Establishment of cardiorenal syndrome rat model
[0035] Rats were anesthetized by intraperitoneal injection of 10% chloral hydrate (0.3 mL•100g-1) and fixed on the operating table. Turn on the ventilator (respiratory frequency 72 times min-1, tidal volume 18mL, respiratory ratio 1: 2), and insert a tracheal tube from the mouth of the rat....
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating cardiorenal syndrome. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight of traditional Chinese medicines: 5-20 parts of Radix Polygoni Multiflori, 8-24 parts of Whole Trichosanthes, 10-20 parts of Ligustrum lucidum, 8-16 parts of Shichangpu, 6 parts of Scallops ‑18 servings. Preferably, the parts by weight of the above-mentioned traditional Chinese medicine composition of the present invention are: 16 parts of Radix Polygoni Multiflori, 24 parts of Whole Trichosanthes, 16 parts of Ligustrum lucidum, 15 parts of Shichangpu, and 12 parts of Scallop. The invention of the traditional Chinese medicine composition is based on the principle of treating the heart and the kidney together, taking into account both the symptoms and the symptoms, with the principles of dredging yang and dispelling stagnation, promoting qi and eliminating phlegm, nourishing the kidney and nourishing yin. Among them, Baishouwu is the monarch drug, which nourishes the kidney and essence, nourishes the blood and nourishes the blood, Gualou disperses phlegm and resolves stagnation, Ligustrum lucidum nourishes the liver and kidney yin as the minister drug, Shichangpu promotes blood circulation and dispels wind, and Xie Bai regulates qi and widens the chest as the adjuvant drug. The whole formula starts from nourishing the heart and strengthening the kidney, and nourishing the kidney must be solid. It has a significant therapeutic effect on cardiorenal syndrome and has no toxic side effects. It can significantly improve the quality of life of patients with cardiorenal syndrome, improve the long-term prognosis, and reduce family and social economic burdens. .
Description
technical field [0001] The invention relates to a traditional Chinese medicine composition for preventing and treating cardiorenal syndrome; the invention also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] Cardiorenal syndrome (CRS) refers to heart and kidney comorbidity caused by primary heart or kidney disease or caused by the same cause, which eventually leads to joint damage to heart and kidney function, and is the manifestation of the disease developing to the end stage . Epidemiological data show that renal function worsens in 30% of patients with chronic heart failure (CHF), and 51% of patients with moderate to severe renal failure die. [0003] In traditional Chinese medicine, cardiorenal syndrome belongs to the categories of water-air disease, palpitations, shortness of breath, chest obstruction, phlegm retention, edema, etc. The core of the etiology and pathogenesis of this disease is heart-kidney di...
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