Sofosbuvir and ledipasvir compound preparation
A technology of compound preparations and solubilizers, which is applied in the direction of medical preparations of non-active ingredients, antiviral agents, pill delivery, etc. It can solve the problems of cumbersome preparation methods, unsuitability for large-scale industrial production, poor dissolution rate of ledipasvir, etc. problems, achieve quality control, overcome dissolution problems, and improve initial dissolution rate
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Embodiment 1
[0027]
[0028] Redipavir d0.9=20μm
[0029] Preparation:
[0030] a. Mix sofosbuvir, ledipasvir, lactose, sodium lauryl sulfate, and croscarmellose sodium evenly to prepare a mixture;
[0031] b. dry granulating the mixture in step a to obtain drug granules;
[0032] c. Compressing the drug granules into tablets.
Embodiment 2
[0034]
[0035] Redipavir d0.9=25μm
[0036] The preparation method is the same as in Example 1.
Embodiment 3
[0038]
[0039] Redipavir d0.9=30μm
[0040] The preparation method is the same as in Example 1.
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