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Composition for dry sensitive skin and preparation method thereof

A composition and sensitive technology, which is applied in the field of dry and sensitive skin compositions, can solve the problems of no effective method for dry skin sensitivity, poor skin moisture retention, and thin cuticle, so as to improve the sensitive state of the skin and accelerate Circulating metabolism, repairing effect of dry sensitive skin

Inactive Publication Date: 2018-06-08
ZHEJIANG ORIGIN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When dryness and sensitivity coexist, the deterioration of the skin soars, the stratum corneum is thin and fragile, and the skin’s ability to lock water is poor. Even frequent replenishment of water often does not help, but easily leads to discomfort such as erythema and scales
[0007] However, there is currently no fully satisfactory treatment or prevention of sensitive skin
CN 101254159A, CN 101380288A, CN 102665673 A, etc. all provide formulas for improving sensitive skin, but there is no effective method for dry skin sensitive problems

Method used

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  • Composition for dry sensitive skin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of anti-dry muscle liquid comprises the following steps:

[0027] (1) Preparation of neural stem cell lysates

[0028] The human neural stem cells were cooled in liquid nitrogen for 30 minutes, thawed in a cell culture incubator at 37°C, and repeated 3 times; the transmembrane was collected by filtration with a 250nm pore size membrane, and the product was obtained. Put it in 37 ℃ and keep warm for later use.

[0029] (2) Preparation of skin stem cell culture supernatant:

[0030] Configure medium: basal medium is DMEM / F12, 25μg / L VEGF, 35μg / L EGF, 8μg / L NGF, 20mg / L human serum albumin, 25μg / L vitamin E, iron citrate 2mmol / L, grain Aminoamide 2mmol / L, gentamicin 50g / L, putrescine 1.6mg / L. Human skin stem cells were cultured in the culture medium at 37°C for 24 hours, then 1 wt% of the neural stem cell lysate prepared in step (1) was added to the culture medium, and cultured for another 24 hours, then the cell liquid was collected, centrifuged, ...

Embodiment 2

[0035] A composition for dry sensitive skin, its preparation method comprises the following steps:

[0036] 1. Preparation of Neural Stem Cell Lysates

[0037] The human neural stem cells were cooled in liquid nitrogen for 30 minutes, thawed in a cell culture incubator at 37°C, and repeated 5 times; the transmembrane was collected by filtration with a 250nm pore size membrane to obtain the final product. Put it in 37 ℃ and keep warm for later use.

[0038] 2. Preparation of skin stem cell culture supernatant:

[0039] Configure medium: basal medium is DMEM / F12, 30μg / L VEGF, 40μg / L EGF, 10μg / L NGF, 45mg / L human serum albumin, 30μg / L vitamin E, iron citrate 3mmol / L, grain Aminoamide 2mmol / L, gentamicin 80g / L, putrescine 2.0mg / L. Human skin stem cells were cultured in this medium at 37°C for 15 hours, then 1.5wt% of the neural stem cell lysate prepared in step (1) was added to the medium, and cultured for another 60 hours, then the cell liquid was collected, centrifuged, and t...

Embodiment 3

[0043] A composition for dry sensitive skin, its preparation method comprises the following steps:

[0044] 1. Preparation of Neural Stem Cell Lysates

[0045]The human neural stem cells were cooled in liquid nitrogen for 30 minutes, thawed in a cell culture incubator at 37°C, and repeated 3 times; the transmembrane was collected by filtration with a 250nm pore size membrane, and the product was obtained. Put it in 37 ℃ and keep warm for later use.

[0046] 2. Preparation of skin stem cell culture supernatant:

[0047] Configure medium: basal medium is DMEM / F12, 25μg / L VEGF, 30μg / L EGF, 5μg / L NGF, 10mg / L human serum albumin, 20μg / L vitamin E, iron citrate 1mmol / L, grain Aminoamide 1mmol / L, gentamicin 30g / L, putrescine 1.0mg / L. Human skin stem cells were cultured in this medium at 37°C for 30 hours, then 0.6wt% of the neural stem cell lysate prepared in step (1) was added to the medium, and cultured for another 80 hours, then the cell liquid was collected, centrifuged, and t...

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Abstract

The invention provides a composition for dry sensitive skin. The composition is prepared from skin stem cell cultured supernate, hydrolyzed sweet almond protein, vitamin E palmitate, glutathione, polygonatum odoratum extract, troxerutin and camellia-seed oil, wherein neural stem cell lysate is added in the skin stem cell culture medium. The composition can be used for improving the sensitive stateand the dry state of skin, and solving the problems of skin erythema, scale, moisture loss and other problems.

Description

technical field [0001] The invention belongs to the field of beauty and makeup, and mainly relates to a composition for dry and sensitive skin. Background technique [0002] Sensitive skin, also known as sensitive skin syndrome, is a state of highly sensitive skin. Specifically, it refers to a fragile skin state with strong skin sensitivity, weak resistance, and easy to be stimulated to cause a certain degree of discomfort. Unlike allergic skin, this reactivity is not caused by an immune response to the presence of an allergen. [0003] There are many factors that cause skin sensitivity, the most direct and common is the result of cumulative damage to the skin caused by inferior cosmetics. In addition, various factors such as food, certain substances in the air, and equipment used [0004] May cause skin allergies. Common triggers are: cosmetics, chemicals, ultraviolet rays, food, pollen, mites, pesticides, fertilizers, dust, animal fur, detergents, hair dyes, metal jewel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/9794A61K8/92A61K8/67A61K8/64A61K8/60A61Q19/00
CPCA61K8/602A61K8/64A61K8/645A61K8/678A61K8/922A61K8/97A61K8/99A61K2800/10A61Q19/00A61Q19/005A61Q19/007
Inventor 江克光宣丹英谭德松何祖法
Owner ZHEJIANG ORIGIN BIOTECH
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