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Porous injectable calcium phosphate bone cement compound

A technology of calcium phosphate bone cement and composites, applied in drug delivery, medical science, prostheses, etc., can solve the problems of increasing composite porosity, accelerating CPC degradation, incomplete degradation, etc., to achieve good biocompatibility and Bone repair ability, accelerated degradation effect

Inactive Publication Date: 2018-06-05
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention aims to solve the defects that the existing bone cement is incompletely degraded in the human body, has no osteoinductive activity, and often releases monomers and generates other degradation products in a physiological environment or after being implanted in the body, causing adverse effects on the human body. A method to improve the degradation of calcium phosphate composite bone cement, on the basis of calcium phosphate inorganic bone cement that has been developed and widely used, combines chondroitin sulfate particles with good biocompatibility and degradability in the form of porogen with Calcium phosphate bone cement composite, increasing the porosity of the composite can accelerate the degradation of CPC, and at the same time, play the active role of chondroitin sulfate in the process of osteogenesis, and promote the degradation of calcium phosphate bone cement into bone

Method used

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  • Porous injectable calcium phosphate bone cement compound
  • Porous injectable calcium phosphate bone cement compound
  • Porous injectable calcium phosphate bone cement compound

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preparation example Construction

[0019] Preparation of chondroitin sulfate:

[0020] Chondroitin sulfate was prepared by enzymatic hydrolysis-resin extraction process, the animal cartilage was minced, hydrolyzed with protease at 55°C for 20 hours, neutralized with hydrochloric acid to near neutrality, filtered, and the concentration of sodium chloride in the filtrate was adjusted to 0.5mol / L , the solution is absorbed through the ion exchange resin column, washed with 0.5mol / L sodium chloride solution, then eluted with 1.8mol / L sodium chloride solution, the flow rate is 2L / h, the eluent is ethanol precipitated, and the precipitate is collected , dry, can prepare the chondroitin sulfate with higher purity, the chondroitin sulfate prepared above adopts 150 and 300 mesh screens, separates the chondroitin sulfate particles whose particle diameter is 50um~100um for later use; wherein, the molecular weight of chondroitin sulfate 10,000 to 30,000.

Embodiment 1

[0022] A porous injectable calcium phosphate bone cement composite, using the spare chondroitin sulfate granules as a porogen, and the amount of chondroitin sulfate granules accounts for 20% of the total mass of solid-phase calcium phosphate bone cement and chondroitin sulfate granules , respectively weighed the spare chondroitin sulfate granules and solid-phase calcium phosphate bone cement, and then mixed and shaken the chondroitin sulfate granules and solid-phase calcium phosphate bone cement to obtain a mixture, and added 0.4 ml of liquid-phase calcium phosphate bone cement, add liquid-phase calcium phosphate bone cement to the mixture and mix evenly to obtain a porous injectable calcium phosphate bone cement composite; wherein, the solid-phase calcium phosphate bone cement is calcium phosphate powder, The liquid phase calcium phosphate bone cement is 4% Na by mass fraction 2 HPO 4 solution.

Embodiment 2

[0024] A porous injectable calcium phosphate bone cement composite, using the spare chondroitin sulfate granules as a porogen, and the amount of chondroitin sulfate granules accounts for 10% of the total mass of solid-phase calcium phosphate bone cement and chondroitin sulfate granules , respectively weighed the spare chondroitin sulfate granules and solid-phase calcium phosphate bone cement, and then mixed and shaken the chondroitin sulfate granules and solid-phase calcium phosphate bone cement to obtain a mixture, and added 0.4 ml of liquid-phase calcium phosphate bone cement, add liquid-phase calcium phosphate bone cement to the mixture and mix evenly to obtain a porous injectable calcium phosphate bone cement composite; wherein, the solid-phase calcium phosphate bone cement is calcium phosphate powder, The liquid phase calcium phosphate bone cement is 4% Na by mass fraction 2 HPO 4 solution.

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Abstract

The invention discloses a porous injectable calcium phosphate bone cement compound. A chondroitin sulfate particle is used as a pore-foaming agent, and is uniformly mixed with solid-phase calcium phosphate bone cement; afterwards, an obtained mixture is uniformly mixed and agitated with liquid-phase calcium phosphate bone cement, so that the porous injectable calcium phosphate bone cement compoundis obtained, wherein the amount of the chondroitin sulfate particle accounts for 10 to 30 percent of the total mass of the solid-phase calcium phosphate bone cement and the chondroitin sulfate particle. The porous injectable calcium phosphate bone cement compound prepared by the invention has the internal pore size of 10 to 50 microns and the porosity reaching approximately 60 percent, can be used for forming favorable pore connectivity, is used for accelerating the degradation of bone cement, further, has favorable biocompatibility and bone repair capacity, and can be used as a novel bionicbone repair material for bone tissue of a human body.

Description

technical field [0001] The invention relates to a calcium phosphate bone cement compound, in particular to a porous injectable calcium phosphate bone cement compound using chondroitin sulfate particles as a porogen. Background technique [0002] As the world enters the era of aging, human bone defects caused by tumors, aging degenerative changes, trauma, congenital development and other reasons are showing a rapid growth trend, and the demand for bone defect repair filling and scaffold materials has also doubled accordingly. In view of human bone tissue Due to the complexity of shape, structure and function, various artificial bone substitute materials have various defects in different aspects at present. Research and preparation of new bone biosubstitute materials with high biological activity, excellent mechanical properties and bionic structure is currently the An urgent need in clinical medicine. [0003] Calcium Phosphate Cement (CPC) is a polymer degradable bone subst...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/50A61L27/12A61L27/20A61L27/54
CPCA61L27/12A61L27/20A61L27/50A61L27/54A61L27/56A61L2300/236A61L2300/412A61L2400/06A61L2430/02C08L5/08
Inventor 廖红兵周强强刘慧胡焕英陈晓薇曲仁飞
Owner GUANGXI MEDICAL UNIVERSITY
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