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Construction of Tween 80-based biocompatible microemulsion and in vitro release and oxidation resistance study of carried apigenin

A technology of apigenin and microemulsion, applied in the directions of emulsion delivery, antidote, drug combination, etc., can solve the problems of poor water solubility and practical utilization limitation, and achieve the effect of improving solubility and good sustained release effect.

Active Publication Date: 2018-06-05
海生健康科技(青岛)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its poor water solubility limits its practical application.

Method used

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  • Construction of Tween 80-based biocompatible microemulsion and in vitro release and oxidation resistance study of carried apigenin
  • Construction of Tween 80-based biocompatible microemulsion and in vitro release and oxidation resistance study of carried apigenin
  • Construction of Tween 80-based biocompatible microemulsion and in vitro release and oxidation resistance study of carried apigenin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Put 1.7g Tween80, 0.15g IPM, and 0.15g PEG 400 in a stoppered colorimetric tube, mix it evenly with a vortex mixer, and stir it well to dissolve it. Then, 8 g of double-distilled water was added dropwise into the colorimetric tube, and fully stirred in a constant temperature water bath at 50-60° C. to dissolve it. Finally, let it stand in a constant temperature water bath at 25°C to achieve phase equilibrium, and the obtained microemulsion is the drug-loaded microemulsion, denoted as P 1 .

Embodiment 2

[0040] Put 1.8g Tween80, 0.1g IPM, and 0.1g PEG 400 in a stoppered colorimetric tube, mix them evenly with a vortex mixer, stir well to dissolve them. Then, 8 g of double-distilled water was added dropwise into the colorimetric tube, and fully stirred in a constant temperature water bath at 50-60° C. to dissolve it. Finally, let it stand in a constant temperature water bath at 25°C to achieve phase equilibrium, and the obtained microemulsion is the drug-loaded microemulsion, denoted as P 2 .

Embodiment 3

[0042] Put 1.9g Tween80, 0.05g IPM, and 0.05g PEG 400 in a stoppered colorimetric tube, mix it evenly with a vortex mixer, and stir it well to dissolve it. Then, 8 g of double-distilled water was added dropwise into the colorimetric tube, and fully stirred in a constant temperature water bath at 50-60° C. to dissolve it. Finally, let it stand in a constant temperature water bath at 25°C to achieve phase equilibrium, and the obtained microemulsion is the drug-loaded microemulsion, denoted as P 3 .

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Abstract

The invention relates to construction of Tween 80-based biocompatible microemulsion and in vitro release and oxidation resistance study of carried apigenin. A pseudo-ternary phase diagram is adopted for constructing Tween80 / IPM / PEG400 / H2O biocompatible microemulsion, and partition is carried out by utilizing conductivity, so that structure of the microemulsion is changed from a bicontinuous phase(B.C.) to an O / W type. Further the O / W type microemulsion is selected as an apigenin carrier, saturation solubility experiments show that the constructed microemulsion obviously improves solubility ofthe apigenin, and compared with the solubility in water, the solubility is improved by 300 times when the microemulsion is taken as the carrier. In vitro release experiments show that the microemulsion has better slow-release effect on the apigenin, and a releasing process of the apigenin in the microemulsion accords with first-order kinetics and is under concentration diffusion control. A medicine still has better antioxidant activity in the microemulsion and has better clearing effect on ABTS<+>.. Release rate of the apigenin in the microemulsion, accumulated release rate and antioxidant activity can be regulated and controlled by changing a mass ratio of a surfactant to oil (S / O) and water content.

Description

technical field [0001] The invention belongs to the field of apigenin drug delivery system, and in particular relates to the construction of Tween 80-based biocompatible microemulsion, the in vitro release and antioxidant performance research of loaded apigenin. Background technique [0002] Apigenin (API) is a common flavonoid compound widely found in various fruits, plants and vegetables. Found in various fruits and vegetables. API has a wide range of pharmacological applications, including anti-virus, anti-oxidation, anti-inflammatory, anti-cancer, etc. Due to its potential physiological activity, it has received extensive attention in the fields of food and medicine. However, its poor water solubility limits its practical application. Therefore, the aggregates constructed by surfactants, such as lyotropic liquid crystals, micelles, etc., can be used to encapsulate the drug, improve the solubility of the drug, and provide an efficient delivery carrier for the utilizati...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/26A61K47/10A61K47/14A61K31/352A61P39/06
CPCA61K9/1075A61K31/352A61K47/10A61K47/14A61K47/26
Inventor 王仲妮董爽爽
Owner 海生健康科技(青岛)有限公司
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