Micronano bioactive glass microsphere prepared by microemulsion technology and preparation method thereof

Abstract

The invention discloses a micronano bioactive glass microsphere prepared by the microemulsion technology and a preparation method thereof. The preparation method of the micronano bioactive glass microsphere includes the following steps that 1, water, ethanol, an organic solvent and a surfactant are used for preparing a mixed solution, tetraethyl orthosilicate, a catalyst, triethyl phosphate and calcium nitrate are sequentially added, and the mixture is stirred evenly to obtain a bioactive glass gel solution; 2, the bioactive glass gel solution is centrifuged and cleaned, a wet gel precipitateis obtained, and the wet gel precipitate is placed in a drying oven for drying, and bioactive glass gel powder is obtained; 3, the bioactive glass gel powder is placed in a high-temperature furnace for heat treatment, and the micronano bioactive glass microsphere is obtained. The prepared micronano bioactive glass microsphere has the advantages of being good in dispersion and uniform in particle size distribution, and is a novel bone and dental regeneration and repair material.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a micro-nano bioactive glass microsphere prepared by microemulsion technology and a preparation method thereof. Background technique [0002] In the early 1970s, Professor Hench obtained 45S5 (mass percentage: 45%SiO 2 -24.5%Na 2 O-24.5%CaO-6%P 2 o 5 ) Bioactive glass, which has good biocompatibility and bioactivity, has been used in clinical bone, tooth and skin tissue repair. However, the preparation process of the melting method has harsh preparation conditions (preparation at a high temperature of about 1400 degrees), high energy consumption, and easily leads to material impurity ion doping, and the surface of the material particles is dense and the specific surface area is small, which is not conducive to ion release and in vivo degradation. [0003] In recent years, the bioactive glass prepared by the sol-gel method provides a good preparation for the preparation of ...

AI Technical Summary

Problems solved by technology

However, the bioactive glass prepared by a single sol-gel method still has the disadvantages of uncontrollable particle shape, severe particle agglomeration, and poor dispersion.

Some researchers have improved the dispersion and morphology of bioactive glass in the micron-scale range by introducing organic templates, but bioactive glass particles in the nano-scale range still have shortcomings such as serious agglomeration, poor dispersion, and uneven particle size distribution.

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