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Liniment for treating vitiligo and preparation method of liniment

A technology of vitiligo and solvents, which is applied in the field of medicine, can solve the problems of poor drug compliance, complicated preparation process, and large toxic and side effects, and achieve the effects of small side effects, simple preparation process, and low cost

Pending Publication Date: 2018-05-25
JIANGSU LINGBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the existing problems of betamethasone injection, such as complex preparation process, poor drug compliance of patients, relatively high toxicity and side effects, and easy relapse after drug withdrawal, the present invention aims to provide a simple preparation process and convenient use for the treatment of Liniment for Vitiligo

Method used

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  • Liniment for treating vitiligo and preparation method of liniment
  • Liniment for treating vitiligo and preparation method of liniment
  • Liniment for treating vitiligo and preparation method of liniment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1- Embodiment 9

[0032] Embodiment 1-Embodiment 9: Utilize pigment to formulate coloring agent.

[0033] According to the pigment components and dosage in Table 1, the pigments were formulated into three colorants of yellow, brown and black for use by people suffering from vitiligo with different skin colors. The specific preparation process is as follows: under stirring conditions, according to the ratio of 1mg pigment: 1mL water, add various required pigments to the water in sequence, visually observe the dissolution or dispersion, and continue stirring for 10 minutes to obtain the prepared colorant.

[0034] Table 1. Experimental results of coloring agent deployment

[0035]

[0036]

[0037] After comparing the coloring agents of the same color, it was found that the coloring agent formulated with 1 part of lemon yellow, 2 parts of sunset yellow and 1 part of titanium dioxide is closer to the skin color of the yellow race, and 1 part of caramel pigment and 1 part of titanium dioxide ...

Embodiment 10- Embodiment 12

[0038] Example 10-Example 12: Preparation of liniment.

[0039] Table 2. The prescription composition of liniment

[0040]

[0041] Weigh betamethasone acetate or betamethasone acetate and tacrolimus according to the amount in Table 2, add it to an appropriate amount of 75% ethanol, and stir to obtain the main drug solution; weigh the low-molecular weight according to the amount in Table 2 Sodium hyaluronate (average molecular weight is 40~80kDa), dimethyl sulfoxide, penetration aid and coloring agent (preparation is carried out according to the prescription in embodiment 1, embodiment 5 and embodiment 7), low molecular weight hyaluronic acid Add sodium bicarbonate into an appropriate amount of 75% ethanol, stir evenly, add dimethyl sulfoxide, penetration aid and coloring agent in turn, and selectively add fragrance, after stirring evenly, obtain the auxiliary material solution; add the main drug solution Add it to the auxiliary material solution, adjust the volume to 1000...

experiment example 1

[0042] Experimental Example 1: Skin irritation experiment of liniment for treating vitiligo.

[0043] Adopt the liniment in embodiment 10 to embodiment 14 to carry out skin irritation experiment, concrete experiment process is as follows: choose the rabbit that body weight is 2.0~2.5kg as experimental animal, use scissors and electric shaver 24 hours before the experiment in rabbit A region was shaved on both sides of the back spine, with a size of about 10cm×5cm, wherein the upper half was the intact skin test area, the lower half was the damaged skin test area, and the left side was coated with the test drug or positive control (product name: 100 Dianling liniment, batch number: 151204, manufacturer: Jiangsu Lingbao Pharmaceutical Co., Ltd.), the application amount is 1.0mL, and the right side is its own blank control; the skin on the left and right sides of the damaged skin test area is treated with surgical treatment before administration. The knife cuts the skin, forming ...

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Abstract

The invention belongs to the technical field of medicines and relates to a liniment for treating vitiligo and a preparation method of the liniment. The liniment is prepared from betamethasone acetate,low molecular sodium hyaluronate, dimethyl sulfoxide, a penetrant aid, a coloring agent and a solvent. According to the liniment, good drug permeability and pigment retention are realized through a special penetration promoter, treatment of vitiligo and white spot covering of skin damage parts are completed simultaneously, betamethasone acetate and tacrolimus are used together, and the synergistic interaction function is realized. The preparation process of the liniment is simple, the liniment is easy to produce and operate and convenient to use and has small side effects, and the drug compliance of patients is notably improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a liniment for treating vitiligo and a preparation method thereof. Background technique [0002] Vitiligo is a common multiple pigmented skin disease, which is characterized by localized or generalized depigmentation and the formation of leukoplakia. It is caused by the decrease or loss of the function of the amino acid enzyme system. Vitiligo has incidence cases all over the world, and the prevalence rate in my country is about 1%, and about half of the patients develop the disease before the age of 20. So far, the etiology of the disease is still unclear, and most scholars believe that it is related to genetic, immune and neurological factors. Vitiligo is easy to diagnose but difficult to cure. There are various treatment methods, most of which aim to increase the number of melanocytes in the skin lesion and restore the color of the damaged skin to normal. [0003] Betamethas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K47/36A61K47/20A61P17/00A61K31/436
CPCA61K47/20A61K47/36A61K9/0014A61K31/436A61K31/573A61K2300/00
Inventor 浦洁王有志陈旭升王德才
Owner JIANGSU LINGBAO PHARMA
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