Preparation method of electro-deposited hydroxyapatite in choline chloride based ionic liquid

A choline chloride and ionic liquid technology, applied in the field of biomedical materials, can solve the problems of difficulty in providing hydroxyl groups, restrictions, etc., and achieve the effects of reducing hydrogen evolution, improving density, and simple process operation

Active Publication Date: 2018-05-22
TIANJIN AGRICULTURE COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although non-aqueous ionic liquids (imidazolium salt ions and pyrrole salt ions, etc.) can avoid hydrogen embrittlement and pH changes caused by hydrogen evolution, they are sensitive to air and water, and must be kept under harsh conditions such as vacuum and inert gas protection. operating under conditions, and it is difficult to provide the hydroxyl group required for the preparation of HA, the practical application is limited

Method used

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  • Preparation method of electro-deposited hydroxyapatite in choline chloride based ionic liquid
  • Preparation method of electro-deposited hydroxyapatite in choline chloride based ionic liquid
  • Preparation method of electro-deposited hydroxyapatite in choline chloride based ionic liquid

Examples

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Comparison scheme
Effect test

Embodiment 1

[0019] Method for preparing HA coating by ultrasonic-pulse electrodeposition in choline chloride-urea ionic liquid

[0020] Weigh 50 g of dried choline chloride and 72 g of urea, and control the temperature in an oil bath at 80°C to prepare a colorless and uniform choline chloride-urea ionic liquid, and then add CaCl 2 and NH 4 h 2 PO 4 Further dissolves, regulates Ca 2+ The concentration is 10 mmol∙L -1 , H 2 PO 4 2- The concentration is 6 mmol∙L -1 , join H 2 o 2 3 mL, adjust the pH of the solution to 4.6, and complete the preparation of the electrodeposition solution.

[0021] Under the composition of the above electrodeposition solution, the temperature of the solution is controlled at 80°C, the ultrasonic power is 300 W, and the ultrasonic frequency is 80kHz. The HA coating is prepared by unidirectional positive pulse electrodeposition. The pulse electrodeposition waveform is as attached figure 1 As shown, the pulse average current density is 5mA∙cm -2 , with ...

Embodiment 2

[0023] Method for preparing HA coating by ultrasonic-pulse electrodeposition in choline chloride-ethylene glycol ionic liquid

[0024] Weigh 60 g of dried choline chloride and 80 g of ethylene glycol, and control the temperature in an oil bath at 90°C to prepare a colorless and uniform choline chloride-ethylene glycol ionic liquid, and then add CaCl 2 and NaH 2 PO 4 Further dissolves, regulates Ca 2+ The concentration is 10 mmol∙L -1 , H 2 PO 4 2- The concentration is 5.5 mmol∙L -1 , join H2 o 2 2 mL, adjust the pH of the solution to 4.8, and complete the preparation of the electrodeposition solution.

[0025] Under the above electrodeposition solution composition, the temperature of the solution was controlled at 90 °C, the ultrasonic power was 200 W, and the ultrasonic frequency was 100 kHz. The HA coating was prepared by unidirectional positive pulse electrodeposition, and the pulse average current density was 4 mA∙ cm -2 , with a turn-on time of 8 s, a turn-off t...

Embodiment 3

[0027] Method for preparing HA coating by ultrasonic-pulse electrodeposition in choline chloride-glycerol ionic liquid

[0028] Weigh 80 g of dried choline chloride and 100 g of glycerol, and control the temperature in an oil bath at 90°C to prepare a colorless and uniform choline chloride-glycerol ionic liquid, and then add Ca(NO 3 ) 2 and NH 4 h 2 PO 4 Further dissolves, regulates Ca 2+ The concentration is 15mmol∙L -1 , H 2 PO 4 2- The concentration is 8 mmol∙L -1 , join H 2 o 2 4 mL, adjust the pH of the solution to 5.5, and complete the preparation of the electrodeposition solution.

[0029] Under the above electrodeposition solution composition, the temperature of the solution was controlled at 90 °C, the ultrasonic power was 300 W, and the ultrasonic frequency was 60 kHz. The HA coating was prepared by unidirectional positive pulse electrodeposition, and the pulse average current density was 10 mA∙ cm -2 , with a turn-on time of 12 s, a turn-off time of 6 s...

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Abstract

The invention provides a preparation method of ultrasonic-pulse electro-deposited hydroxyapatite (HA) in choline chloride based ionic liquid. According to the technical scheme, the preparation methodcomprises the following steps: taking the choline chloride based ionic liquid as a solvent; adding a compound which contains Ca and P in the solvent according to the quantity relative ratio that the concentration of Ca2+ is 2-50 mmol-L-1, and the concentration of H2PO42- is 1-30 mmol-L-1; and adding 1-10% of an additive H2O2 to prepare an electro-deposited solution of HA. Under an ultrasonic condition, an HA coating is prepared by a one-way positive pulse electrodeposition method. By the preparation method, hydrogen evolution can be relieved effectively, concentration polarization is weakened,and the structural compactness of HA is improved. The preparation method has the advantages of simplicity in operation, easiness in preparation, safety, reliability and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a method for preparing a hydroxyapatite coating by ultrasonic-pulse electrodeposition using a choline chloride-based ionic liquid as a solvent. Background technique [0002] Hydroxyapatite (HA) has a chemical composition and crystal structure similar to that of the main mineral apatite in human bones and teeth. It is the main inorganic component of human bone tissue and is the most representative Biomedical materials with good biocompatibility and bioactivity can induce bone tissue to grow on its surface in a short time after implanted in the human body, and form a good chemical bond with bone tissue, which can be used as a substitute material for human bones. and has been applied clinically. However, HA material has poor mechanical properties and high brittleness. Attaching it to the surface of titanium or titanium alloy as a hard tissue implant material is an effective meth...

Claims

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Application Information

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IPC IPC(8): C25D9/04C25D5/18A61L27/32A61L27/50
CPCA61L27/32A61L27/50A61L2420/02A61L2430/02C25D5/18C25D9/04
Inventor 卜路霞田琳
Owner TIANJIN AGRICULTURE COLLEGE
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