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Miconazole nitrate emulsifiable paste and preparation method thereof

A technology of miconazole nitrate cream and miconazole nitrate, which is applied in the directions of pharmaceutical formulation, ointment delivery, emulsion delivery, etc., can solve the problems of large skin damage, secondary infection, and difficulty in cleaning, and achieve small skin damage, Uniform mixing and easy coating

Inactive Publication Date: 2018-05-18
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing miconazole nitrate cream is not easy to disperse and apply, and after application, it will cause great damage to human skin, and it is difficult to clean up, and it is easy to cause secondary infection. It is not easy to mix evenly between the oil phases, and it takes a lot of man-hours
For example, the patent number is CN01127644.4, and the patent name is: the preparation method of miconazole nitrate ointment, the ointment prepared by this preparation method is not easy to apply, and it is difficult to clean after application
The patent number is CN200910010074.2, and the patent name is: miconazole nitrate cream and preparation method. It is difficult to mix the raw and auxiliary materials evenly, which will easily affect the curative effect of miconazole nitrate. The preparation process will consume a lot of manpower and material resources, which increases the production cost.

Method used

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  • Miconazole nitrate emulsifiable paste and preparation method thereof
  • Miconazole nitrate emulsifiable paste and preparation method thereof

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preparation example Construction

[0021] The present invention also provides a kind of preparation method of miconazole nitrate cream, comprising the following steps:

[0022] S1, mixing for the first time;

[0023] Mix miconazole nitrate, dispersant, 70-80% oil-water mixture and water phase mixture. The amount of the oil-water mixture used in the first mixing is 70%-80% of the total amount of the oil-water mixture, in order to be more conducive to the dispersion of the active ingredient, and at the same time, to facilitate the dispersion of each substance in the water phase mixture, and then ensure the dispersion of the drug Uniformity, improve the performance of cream coating.

[0024] Specifically, mix disodium edetate and carbomer with triethanolamine and sodium hydroxide, then mix with miconazole nitrate and a dispersant, then mix with benzoic acid, 2,6 di-tert-butyl The mixture of p-cresol, 70-80% oil-water mixture and dimethyl sulfoxide is the first mixture.

[0025] Mix disodium edetate and carbomer...

Embodiment 1

[0036] The present embodiment provides a kind of miconazole nitrate emulsifiable paste, and it is mainly made of various raw materials, and multiple raw materials include 4kg miconazole nitrate, 11.6kg water phase mixture, 10kg oily phase mixture, 5kg oil-water mixture and 20kg dispersant. The final miconazole nitrate accounts for 2% of the total amount of emulsifiable cream, while the remaining raw and auxiliary materials are purified water. Among them, the 11.6kg aqueous phase mixture includes 1.4kg carbomer, 0.2kg edetate disodium, 0.8kg sodium hydroxide and 5kg dimethyl sulfoxide; 3kg triethanolamine, 1kg benzoic acid, 0.2kg2,6 di tert-butyl-p-cresol. 10 kg of the oil phase mixture included 6 kg of glyceryl stearate and macrogol 100 stearate and 4 kg of macrogol 4000. The dispersant is 1,2 propylene glycol, and the oil-water mixture is polysorbate 80.

[0037] The present invention also provides a kind of method for preparing miconazole nitrate cream, comprising the fol...

Embodiment 2

[0047] The present embodiment provides a kind of miconazole nitrate emulsifiable paste, and it is mainly made of various raw materials, and multiple raw materials include 5kg miconazole nitrate, 10kg water phase mixture, 9kg oily phase mixture, 3kg oil-water mixture and 17.8 kg dispersant. The final miconazole nitrate accounts for 2% of the total amount of emulsifiable cream, while the remaining raw and auxiliary materials are purified water. Among them, 10kg of aqueous phase mixture includes 1 carbomer, 0.4kg of disodium edetate, 0.6kg of sodium hydroxide and 4.8kg of dimethyl sulfoxide; 2kg of triethanolamine, 1kg of benzoic acid, 0.2kg of 2,6 di-tert Butyl p-cresol. 9 kg of the oil phase mixture comprised 5 kg of glyceryl stearate and macrogol 100 stearate and 4 kg of macrogol 4000. The dispersant is 1,2 propylene glycol, and the oil-water mixture is polysorbate 80.

[0048] The present invention also provides a kind of method for preparing miconazole nitrate cream, comp...

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Abstract

The invention relates to the field of pharmacy, in particular to a miconazole nitrate emulsifiable paste and a preparation method thereof. The miconazole nitrate emulsifiable paste is mainly preparedfrom the following raw materials and auxiliary materials: 4-6 parts of miconazole nitrate, 10-12.4 parts of a water-phase mixture, 9-12 parts of an oil-phase mixture, 3-5 parts of an oil-water mixtureand 17.8-30.4 parts of a dispersant. The emulsifiable paste is stable in long-time storage property, uniform and smooth in texture and easy to coat, and has a good moisturizing effect after coating;and injury of the miconazole nitrate emulsifiable paste to the skin is relieved.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a miconazole nitrate cream and a preparation method thereof. Background technique [0002] Miconazole Nitrate Cream is an over-the-counter drug for dermatology and gynecology. It is a broad-spectrum antifungal drug. Its mechanism of action is to inhibit the synthesis of fungal cell membranes and affect its metabolic process. It has antibacterial effects on dermatophytes and candida, and has certain curative effects on some Gram-positive cocci. The existing miconazole nitrate cream is not easy to disperse and apply, and after application, it will cause great damage to human skin, and it is difficult to clean up, and it is easy to cause secondary infection. It is not easy to mix evenly between the oil phases, and it takes a lot of man-hours. For example, the patent No. is CN01127644.4, and the patent name is: the preparation method of miconazole nitrate ointment, the ointment prepared by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/10A61K31/4174A61P31/10A61P17/00A61P15/00
CPCA61K9/06A61K9/0014A61K31/4174A61K47/10
Inventor 罗磊唐攀杨莉朱锋梅勇袁开超龙涛左娟王凤
Owner 重庆希尔安药业有限公司
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