an h that can be used in skin dressings 2 s-donor compound, sponge dressing and method of preparation

Abstract

The invention discloses a H2S donor compound capable of being used for skin dressing, sponge dressing and a preparation method, and relates to H2S donor compounds, sponge dressing and preparation methods. The invention firstly aims to provide a H2S donor compound CW-1 capable of being used for skin dressing. The compound can transfer H2S gas molecules to skin specifically and byproducts thereof have the antibacterial action. The invention secondarily aims to provide dressing suitable for skin. The dressing is sponge dressing of calcium alginate comprising the H2S donor compound CW-1. The dressing can be in contact with skin wounds, can transfer H2S gas molecules of a therapeutic dose stably to the skin of wounds effectively, and plays an antibacterial role.

Description

technical field The present invention relates to a H 2 S-donor compound, sponge dressing and method of preparation. Background technique h 2 S, a colorless gas molecule with the smell of rotten eggs, has long been considered a poisonous gas that can cause environmental pollution. However, recent studies have found that the toxic gas molecule H 2 Like nitric oxide (NO) and carbon monoxide (CO), S is an important endogenous gas signal molecule involved in various physiological and pathological processes. Mammals can synthesize H 2 S, mainly catalyzed by cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS) to metabolize cysteine. In the cardiovascular system H 2 S is mainly synthesized by CSE, while H in the nervous system 2 S is mainly synthesized by CBS catalysis. Under physiological conditions H 2 The concentration of S is 1-160μM, of which the brain reaches 50-160μM, and the blood reaches 10-160μM. Endogenous H 2 S has a variety of biological functions,...

AI Technical Summary

Problems solved by technology

Among them, GYY4137 is the most commonly used donor compound, which can be hydrolyzed in water and slowly release H 2 S, but this release method is too slow, and it needs the help of organic solvents such as acetone or chloroform to hydrolyze quickly, and it takes 71 days for complete hydrolysis

The core structure or phosphorothioate of GYY4137 is considered to be the design H 2 Effective templates for S-donor compounds, but new activation mechanisms still need to be developed

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