Multivalent meningococcus conjugated vaccine and preparation method thereof
A meningococcal and conjugation technology, applied in the biological field, can solve the problem of low expression level of fHbp protein, achieve the best immune effect and reduce the risk
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[0046] A multivalent meningococcal conjugate vaccine based on the ΔfHbp-NadA protein carrier provided by the present invention will be further described below in conjunction with specific examples. The embodiments described below are exemplary only for explaining the present invention and should not be construed as limiting the present invention.
[0047] The experimental methods in the following examples are conventional methods unless otherwise specified. The experimental materials used in the following examples were purchased from the market unless otherwise specified.
[0048] 1. Cloning and prokaryotic expression of ΔfHbp and ΔfHbp-NadA recombinant proteins
[0049] 1. Construction of Pet-ΔfHbp and Pet-ΔfHbp-NadA recombinant plasmids
[0050] fHbp is a membrane surface lipoprotein, and many strains of meningococcus have its gene, and strains that do not carry the gene have also been found. According to the antigenic cross-reactivity and sequence similarity of the whole...
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