A kind of enteral nutrition preparation combining konjac manna oligosaccharide and L-glutamine and its application

A technology of enteral nutrition preparation and mannose oligosaccharides, which is applied in the field of medicine, can solve problems such as lowering blood lipids, achieve the effects of regulating blood sugar, good patient compliance, and enhancing immunity

Active Publication Date: 2020-04-10
WUHAN GENERAL HOSPITAL OF GUANGZHOU MILITARY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Mechanism of Konjac Mannooligosaccharides in Lowering Blood Lipids Has Not Been Fully Elucidated

Method used

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  • A kind of enteral nutrition preparation combining konjac manna oligosaccharide and L-glutamine and its application
  • A kind of enteral nutrition preparation combining konjac manna oligosaccharide and L-glutamine and its application
  • A kind of enteral nutrition preparation combining konjac manna oligosaccharide and L-glutamine and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A compounding method of an enteral nutrition preparation combining konjac mannan oligosaccharide and L-glutamine:

[0022] Dissolve 16g of konjac mannan oligosaccharide in 100mL of physiological saline, and then add 3g of L-glutamine to obtain the result.

Embodiment 2

[0024] Therapeutic effect of an enteral nutrition preparation combined with konjac mannan oligosaccharide and L-glutamine on model hyperlipidemia rats:

[0025] 1. The effect of an enteral nutrition preparation combined with konjac mannan oligosaccharide and L-glutamine on the body weight of model hyperlipidemia rats

[0026] Introduction of rat groups: the control group is the negative control group; the model group is the hyperlipidemia group without intervention, KMOS-L is the low-dose KMOS experimental group; KMOS-M is the medium-dose KMOS experimental group; KMOS-H is the high-dose KMOS experimental group. Dose KMOS experimental group; KMOS-HL is a combined high-dose KMOS and L-glutamine group. Except for the control group, the other groups were model groups fed with high-fat diet. As shown in Table 1, from the beginning of the experiment to the fourth weekend, there was no significant difference in the body weight of the rats in each group. At the fifth weekend, that is...

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Abstract

The invention belongs to the technical field of medicines, and particularly discloses an enteral nutrition preparation containing konjac mannan oligosaccharide and L-glutamine and application thereofin hyperlipoidemia nutritional therapy. When the method is adopted in the nutritional therapy of a hyperlipoidemia rat model, a certain curative effect is realized, no toxic and side effects exist, the preparation method is simple, the preparation raw materials are easy to obtain, and the application prospect is wide.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an enteral nutrition preparation combining konjac mannan oligosaccharide and L-glutamine, and also relates to the application of the enteral nutrition preparation in the nutritional treatment of hyperlipidemia. Background technique [0002] Epidemiological studies have shown that the incidence of atherosclerosis and coronary heart disease is closely related to hyperlipidemia, while the levels of triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) are elevated A decrease in the level of high-density lipoprotein cholesterol (HDL-C) is an important indicator of hyperlipidemia. The elevated level of TC is one of the important causes of atherosclerosis, and HDL-C can transport TC in peripheral tissues to the liver to be decomposed into bile acid, and activate lecithin cholesterol transacylase to catalyze the esterification of TC. Serum TC level...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/702A61K31/198A61P3/02A61P3/06
CPCA61K31/198A61K31/702A61K2300/00
Inventor 韩芳李晓迪刘晔
Owner WUHAN GENERAL HOSPITAL OF GUANGZHOU MILITARY
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