A modified carbon nano-dot with near-infrared absorption and near-infrared emission characteristics, its preparation method and application

A carbon nano-dot and near-infrared technology, which is applied in nanotechnology, chemical instruments and methods, and luminescent materials for materials and surface science, can solve the difficulty of red or near-infrared light emission and limit the application of carbon nano-dots And other issues

Active Publication Date: 2021-01-05
CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, although carbon nanodots have good photophysical properties, the absorption spectrum of carbon nanodots in the prior art is still mainly distributed in the ultraviolet, blue, and green light regions, and the emission spectrum is mainly distributed in the blue and green light regions. Infrared light emission is still difficult to realize, especially the near-infrared emission under the excitation of near-infrared light has not been reported, which limits the application of carbon nanodots in deep tissue fluorescence imaging in vivo

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  • A modified carbon nano-dot with near-infrared absorption and near-infrared emission characteristics, its preparation method and application
  • A modified carbon nano-dot with near-infrared absorption and near-infrared emission characteristics, its preparation method and application
  • A modified carbon nano-dot with near-infrared absorption and near-infrared emission characteristics, its preparation method and application

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preparation example Construction

[0060] The present invention provides a method for preparing modified carbon nano-dots described in the above technical solution, comprising the following steps:

[0061] The carbon nano-dots are mixed with a raw material containing an electron-withdrawing group, and the raw material containing an electron-withdrawing group is a compound containing an electron-withdrawing group or a polymer containing an electron-withdrawing group, and reacted to obtain a modified carbon nano-dot.

[0062] The preparation method is simple, low in price and easy to realize industrialization.

[0063] The types of the carbon nano-dots, electron-withdrawing group-containing compounds and electron-withdrawing group-containing polymers are the same as those of the carbon nano-dots, electron-withdrawing group-containing compounds and electron-withdrawing group-containing polymers described in the above technical scheme The types are the same and will not be repeated here.

[0064] The volume ratio ...

Embodiment 1

[0070] Carbon nano-dots with near-infrared absorption and near-infrared luminescence under near-infrared light excitation are prepared by modifying the surface of carbon nano-dots emitting red light with DMSO.

[0071] The preparation method of the carbon nano-dots with near-infrared luminescence under the above-mentioned near-infrared absorption and near-infrared light excitation:

[0072] Dissolve citric acid and urea in DMF at a mass ratio of 1:2 to obtain a transparent solution, place it in a 50ml polytetrafluoroethylene autoclave, react at 160°C for 6h, add NaOH (50mg / ml) solution to the reacted solution, Add a large amount of ethanol to obtain a black solid, wash the solid with water, centrifuge (16000rpm, 5min), freeze-dry to obtain a dark green powder, disperse the powder in an aqueous solution, add dilute HCl solution (5wt%), obtain a precipitate, centrifuge, and wash with water twice Freeze-dry after three times to obtain a black powder, which is carbon nanodots emit...

Embodiment 2

[0078] Carbon nano-dots with near-infrared absorption and near-infrared luminescence under near-infrared light excitation are prepared by modifying the surface of carbon nano-dots emitting orange-red light with DMSO.

[0079] The preparation method of the carbon nano-dots with near-infrared luminescence under the above-mentioned near-infrared absorption and near-infrared light excitation:

[0080] Dissolve citric acid and urea in DMF at a mass ratio of 1:2 to obtain a transparent solution, place it in a 50ml polytetrafluoroethylene autoclave, react at 160°C for 6h, add NaOH (50mg / ml) solution to the reacted solution, A large amount of ethanol was added to obtain a black solid, which was washed with water, centrifuged (16,000 rpm, 5 min), and freeze-dried to obtain a dark green powder, which was carbon nanodots emitting orange-red light.

[0081] Put the dark green powder in a beaker, add DMSO, stand for 1 h, freeze-dry to obtain a black powder, which is carbon nanodots with ne...

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Abstract

The invention provides a modified carbon nano-dot with near-infrared absorption and near-infrared luminescent properties, its preparation method and application. The electron-withdrawing group is prepared by polymer modification; the electron-withdrawing group is selected from one or more of carbonyl, sulfone, sulfoxide, cyano and hydroxyl. The electron-withdrawing group reacts with the surface active sites (C, N, O) of the carbon nano-dots, and is connected to the outer layer and edge of the carbon nano-dots through adsorption and bonding (chemical bonds and hydrogen bonds), and the electron acceptor group The LUMO energy level of the outer layer of the carbon nano-dot is reduced, so that the carbon nano-dot has near-infrared absorption and near-infrared luminescence with high fluorescence quantum efficiency under near-infrared light excitation. The modified carbon nanodots can be applied to near-infrared dyes, fluorescent imaging reagents, anti-counterfeiting reagents or encryption reagents.

Description

technical field [0001] The invention relates to the technical field of carbon nanomaterials, in particular to a modified carbon nanodot with near-infrared absorption and near-infrared luminous properties, a preparation method and application thereof. Background technique [0002] Bio-optical imaging technology has high temporal / spatial resolution and can realize non-destructive real-time dynamic monitoring in vivo. It is an important technology in the field of biomedical imaging at present. Due to the weak absorption, scattering, and autofluorescence of near-infrared light in organisms, using near-infrared light as a light source and performing fluorescence imaging in the near-infrared region can effectively improve the tissue penetration depth of fluorescence imaging. The development of highly efficient near-infrared fluorescence imaging reagents is of great significance to the clinical advancement of bio-optical imaging. [0003] Carbon nanodots (Carbon dots, CDs) have go...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/65C09K11/02G01N21/64B82Y20/00B82Y30/00A61K49/00
CPCA61K49/0019A61K49/0065B82Y20/00B82Y30/00C09K11/025C09K11/65G01N21/6428
Inventor 曲松楠李迪
Owner CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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