Porphyrin zinc europium phosphorus cluster material as well as preparation method and application thereof

A technology of porphyrin zinc and porphyrin europium is applied in the field of porphyrin zinc europium phosphorus cluster materials and their preparation, and can solve the problems of physiological repulsion, slow degradation of photothermal preparations, affecting application ability and the like

Active Publication Date: 2022-07-12
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, black phosphorus is less stable in the air, and black phosphorus itself will degrade rapidly when exposed to air and water, which seriously affects its application ability.
At present, other common photothermal antibacterial materials are mainly metal sulfides and metal oxides. However, these photothermal preparations degrade slowly and easily cause biological safety problems such as physiological rejection.

Method used

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  • Porphyrin zinc europium phosphorus cluster material as well as preparation method and application thereof
  • Porphyrin zinc europium phosphorus cluster material as well as preparation method and application thereof
  • Porphyrin zinc europium phosphorus cluster material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Preparation of porphyrin zinc europium phosphorus cluster material (denoted as BP@Eu-TCPP-Zn)

[0048] In this example, the material preparation process was carried out under nitrogen protection.

[0049] (1) Under the protection of nitrogen, take 100 mg of black phosphorus in bulk, grind it and disperse it in 90 mL of NMP solution, add 10 mL of n-octylamine, stir and mix evenly, and use a cell crusher to ultrasonically peel under the condition of 800w power under ice bath. 30 hours. After ultrasonication, centrifuge at 4000 rpm to take the NMP solution containing black scale in the upper layer, centrifuge at 8000 rpm at high speed to obtain 90 mg of lamellar black phosphorus (BP), and store it under nitrogen in the dark.

[0050] (2) Under nitrogen protection, get black phosphorus (32mg, 1mmol) of sheet layer and disperse in 10mL DMF solution, get europium trichloride (258mg, 1mmol) and dissolve in 10mL DMF solution, the DMF solution of europium trichloride...

Embodiment 2

[0060] Example 2: Preparation of porphyrin zinc europium phosphorus cluster material (BP@Eu-TCPP-Zn)

[0061] In this example, the material preparation process was carried out under nitrogen protection.

[0062] (1) Under the protection of nitrogen, take 100 mg of black phosphorus in bulk, grind it and disperse it in 40 mL of NMP solution, add 0.1 mL of n-octylamine, stir and mix evenly, and then use a cell crusher in an ice bath to sonicate at a power of 800w Peel for 5 hours. After ultrasonication, centrifuge at 4000 rpm to take the upper layer solution to obtain a small amount of lamellar black phosphorus (BP) 15 mg, which is stored under nitrogen in the dark.

[0063] (2) Under nitrogen protection, take the sample lamellar black phosphorus (3.2 mg, 0.1 mmol) prepared in step (1) of Example 1 and disperse it in 10 mL of DMF solution, take europium trichloride (25.8 mg, 0.1 mmol) to dissolve In 10 mL of DMF solution, the DMF solution of europium trichloride was slowly adde...

Embodiment 3

[0066] Example 3: Preparation of porphyrin zinc europium phosphorus cluster material (BP@Eu-TCPP-Zn)

[0067] In this example, the material preparation process was carried out under nitrogen protection.

[0068](1) Under the protection of nitrogen, take 100 mg of black phosphorus in bulk, grind it and disperse it in 120 mL of NMP solution, add 20 mL of n-octylamine, stir and mix evenly, and use a cell crusher to ultrasonically peel under the condition of 800w power under ice bath. 60 hours. After ultrasonication, centrifuge at 4000 rpm to take the upper layer solution to obtain lamellar black phosphorus (BP), 40 mg, which is stored under nitrogen in the dark.

[0069] (2) Under nitrogen protection, take the sample lamellar black phosphorus (32 mg, 1 mmol) prepared in step (1) of Example 1 and disperse it in 10 mL of DMF solution, take europium trichloride (516 mg, 20 mmol) and dissolve it in 10 mL of DMF solution , the DMF solution of europium trichloride was slowly added dr...

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Abstract

The invention provides a porphyrin zinc europium phosphorus cluster material as well as a preparation method and application thereof. Lamellar black phosphorus and europium chloride react with black phosphorus under a noise condition to form europium-doped black phosphorus containing P-Eu and O-Eu bonds; then enabling tetra (4-carboxyphenyl) porphyrin and zinc acetate to react with europium-doped black phosphorus by utilizing solvothermal reaction to obtain a porphyrin zinc europium phosphorus cluster material; the prepared material has good photo-thermal performance, can reduce NAD < + > into NADH under driving of visible light, can be used for reduction catalysis of NAD < + > in a living body, and is expected to become a novel green bacterial bacteriostasis material.

Description

technical field [0001] The invention relates to a porphyrin zinc europium phosphorus cluster material, a preparation method and application thereof, and belongs to the technical field of material preparation and application. Background technique [0002] NAD in normal organisms + The / NADH ratio is always in a state of dynamic equilibrium. This ratio is a very important indicator that can reflect the redox state of the cell, thereby determining the metabolic activity of a cell and the health of the cell. Nicotinamide adenine dinucleotide (NAD + ) and its reduced state NADH are important coenzymes in life processes, and they are involved in redox metabolism and a series of other important biochemical processes in life. Humans respond to NAD + and NADH requirements affect the ratio between the two, resulting in various effects on cellular health and biological processes. Intervention with mitochondria-targeted NADH (reduced form of nicotinamide adenine dinucleotide) / NAD fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/22B01J31/22C07H1/06C07H19/207
CPCC07D487/22B01J31/2243B01J35/004C07H1/06C07H19/207B01J2531/26B01J2531/38B01J2531/025B01J2231/646Y02A50/30
Inventor 陈秋云王军
Owner JIANGSU UNIV
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