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Composition, and preparation method and use thereof

A composition and technology of pueraria root extract, applied in the field of composition and preparation thereof, can solve the problems of difficult quality control, unclear active ingredients, unstable curative effect and the like

Active Publication Date: 2018-03-30
BEIJING YISHENGTANG MEDICAL TECH RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Our previous research results confirmed that the co-extracts of Astragalus, Pueraria Radix and Morus alba compositions have the effects of lowering blood fat, protecting the liver and treating obesity, but the co-extracts of the compositions have unclear active ingredients, low bioavailability, and curative effect. Defects such as instability and difficult quality control

Method used

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  • Composition, and preparation method and use thereof
  • Composition, and preparation method and use thereof
  • Composition, and preparation method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0147] An embodiment of the composition of the present invention comprises Astragalus extract, Pueraria root extract and Morus alba extract, and the mass ratio of the Astragalus extract, Pueraria root extract, and Morus alba extract is 1:1:1 .

[0148] The preparation method of composition comprises the steps:

[0149] (1a) Preparation of Radix Astragali Extract: A. Pulverize Radix Astragali medicinal material, extract once with 6BV volume fraction of 60% ethanol under reflux, 0.5h each time, extraction temperature is 60°C; B, combine extracts, reclaim ethanol, water Dilute to a crude drug concentration of 0.150g / mL to obtain a crude extract; C. Use a macroporous resin to absorb the crude extract obtained in step B, and then use 15BV of water, 8BV of 0.05% NaOH solution and 8BV of The ethanol solution that volume fraction is 10% carries out elution, and elution flow rate is 2mL / min, finally with 15BV volume fraction, the ethanol solution that is 30% carries out elution with t...

Embodiment 2

[0154] An embodiment of the composition of the present invention comprises Astragalus extract, Pueraria root extract and Morus alba extract, and the mass ratio of the Astragalus extract, Pueraria root extract, and Morus alba extract is 2:2:1 .

[0155] The preparation method of composition comprises the steps:

[0156] (1a) Preparation of Radix Astragali Extract: A. Pulverize Radix Astragali medicinal material, reflux extract 3 times with 14BV volume fraction of 65% ethanol, each time for 2.5h, extraction temperature is 100°C; B, combine extracts, reclaim ethanol, water Dilute to a crude drug concentration of 0.300 / mL to obtain a crude extract; C. Use a macroporous resin to absorb the crude extract obtained in step B, and then use 20BV of water, 12BV of 0.3% NaOH solution and 12BV of volume Fraction is that 10% ethanol solution is eluted, and elution flow rate is 3mL / min, is that 50% ethanol solution with 20BV volume fraction is eluted with the flow rate of 3mL / min at last, c...

Embodiment 3

[0161] An embodiment of the composition of the present invention comprises Astragalus extract, Pueraria root extract and Morus alba extract, and the mass ratio of the Astragalus extract, Pueraria root extract, and Morus alba extract is 1:2:1 .

[0162] The preparation method of composition comprises the steps:

[0163] (1a) Preparation of Radix Astragali Extract: A. Pulverize Radix Astragali medicinal material, reflux extract twice with 8BV volume fraction of 70% ethanol, 2 hours each time, extraction temperature is 80°C; B, combine extracts, recover ethanol, dilute with water When the crude drug concentration is 0.075g / mL, the crude extract is obtained; C. Use macroporous resin to absorb the crude extract obtained in step B, and then use 10BV of water, 10BV volume fraction of 0.5% NaOH solution and 10BV volume Fraction is that 10% ethanol solution carries out elution, and elution flow rate is 1mL / min, is that 70% ethanol solution with 10BV volume fraction carries out elution...

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Abstract

The invention discloses a composition. The composition comprises Radix Astragali extract, Radix Puerariae extract and white mulberry root-bark extract according to a mass ratio of (1-2):(1-2):(1-2); or the composition comprises Radix Astragali-Radix Puerariae extract and white mulberry root-bark extract, a mass ratio of Radix Astragali to Radix Puerariae in the Radix Astragali-Radix Puerariae extract is (0.5-5):1, and a mass ratio of the Radix Astragali-Radix Puerariae extract to the white mulberry root-bark extract is 1:1. The invention also discloses a preparation method and a use of the composition. The composition has the advantages of scientific and advanced preparation technology and controllable quality, has blood fat reducing, liver protecting, weight reducing and homocysteine reducing effects, can be effectively used to treat obesity induced hyperlipidemia, fatty liver, obesity and hyperhomocysteinemia, and has significant effects.

Description

technical field [0001] The invention relates to a composition and its preparation method and application, especially the preparation method and application of a composition capable of lowering blood fat, protecting the liver, reducing weight and reducing homocysteine. Background technique [0002] Astragalus, also known as Mianqi, its main active ingredient is astragaloside IV, which has the functions of inhibiting metabolic syndrome, delaying cardiomyopathy in myocardial ischemia, and improving heart function. , diuretic, anti-aging, anti-stress, antihypertensive and a wider range of antibacterial effects. It can eliminate experimental nephritis proteinuria, enhance myocardial contractility, and regulate blood sugar levels. Astragalus can not only dilate coronary arteries, improve myocardial blood supply, improve immune function, but also delay the process of cell aging. [0003] Pueraria lobata is the dried root of the leguminous plant Pueraria mirifica, commonly known a...

Claims

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Application Information

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IPC IPC(8): A61K36/605A23L33/105A61P3/06A61P1/16A61P3/04A61P3/00A61P7/00
CPCA23L33/105A23V2002/00A61K36/481A61K36/488A61K36/605A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00A23V2200/30A23V2200/3262A23V2200/332A23V2250/21A23V2300/14
Inventor 李卫民朱贺年冯毅凡玉荣李铀王春怡李艳
Owner BEIJING YISHENGTANG MEDICAL TECH RES CO LTD
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