Bromhexine hydrochloride nanometer dispersible tablet and preparation method thereof

Abstract

The invention discloses a bromhexine hydrochloride nanometer dispersible tablet and a preparation method thereof. The bromhexine hydrochloride nanometer dispersible tablet is prepared from the following steps of 40 to 60 parts of bromhexine hydrochloride, 30 to 60 parts of filling agent, 2 to 8 parts of swelling auxiliary material, 1 to 5 parts of adhesive, 0.5 to 1 part of lubricant and 1 to 3 parts of sweetening agent, and is prepared by the following steps of stirring, mixing, granulating, and tableting by a plunger type extruder. Compared with commercial cough-relieving tablets, after proofed by detection results, the prepared bromhexine hydrochloride nanometer dispersible tablet has the advantages that the disintegration speed is quick, the dissolving rate and dissolving speed are high, the peak-reaching time of blood concentration is short, the releasing and absorbing rate is quick, the appearance of each tablet is complete, the hardness is stronger, the mouth feel is fine and cool, and the grit feel is avoided; compared with the existing freeze-drying, vacuum-drying and spray-drying type oral disintegration tablet technique, the special production equipment and conditions are not needed, the special package is not needed, the preparation technology is simple, the cost is low, and the benefit is high.

Description

technical field [0001] The invention belongs to the field of drug synthesis, and in particular relates to a bromhexine hydrochloride nano-dispersion tablet and a preparation method thereof. Background technique [0002] Due to the deteriorating environmental quality, air pollution has become a major public hazard that endangers human life. Smoking and drug abuse are becoming more and more common. At the same time, various new viruses, bacteria, chlamydia and other pathogenic microorganisms are complicated. The incidence of respiratory diseases has greatly increased, seriously affecting the quality of life of the public. As a commonly used drug for respiratory diseases, bromhexine hydrochloride not only requires the standardization and standardization of clinical use, but also needs to be further developed and researched to improve its safety and curative effect, thus contributing to the treatment of diseases . [0003] Bromhexine hydrochloride is an expectorant, which is a...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the traditional cough medicine tablets are too large, the production process is complicated, the prepared tablets are low in hardness and fragile, it is difficult to maintain the integrity of the tablets, and special packaging is required to prevent the tablets from breaking. Due to the disadvantages of high production costs, the bromhexine hydrochloride nano-dispersible tablets can be taken according to their own body weight to determine the amount of tablets to be taken, realizing personalized drug administration, making the intake of drugs more accurate and safer; at the same time, the active ingredients of the drug are in the form of nano Highly soluble and dispersible tablets in grade form, which is conducive to full absorption and high bioavailability

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