Preparation method of bendable fully degradable zinc alloy nerve guide

A nerve catheter and zinc alloy technology, applied in medical science, prosthesis, etc., can solve the problems of uncomfortable nerve repair, inability to bend zinc alloy nerve catheter, late research and development, etc., achieve inhibition of bacterial growth, good lumen support effect, prevention The effect of infection

Active Publication Date: 2021-04-02
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, zinc alloy nerve conduits obtained by laser cutting of zinc alloy tubes cannot be bent, and are not suitable for the repair of nerves that need to be bent in joints and other parts. In addition, since the development of zinc alloy as a degradable medical material is later than that of magnesium alloy, zinc alloy fine The preparation of silk materials is rarely reported

Method used

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  • Preparation method of bendable fully degradable zinc alloy nerve guide
  • Preparation method of bendable fully degradable zinc alloy nerve guide

Examples

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Embodiment 1

[0035] Such as figure 1 with figure 2 As shown, the specific embodiment provides a method for preparing zinc alloy wire and a bendable fully degradable zinc alloy nerve guide braided with zinc alloy wire for nerve defect repair. The nerve guide is a round tube structure formed by braiding multiple zinc alloy wires, in which each row of zinc alloy wires forms a certain angle with the tube axis of the round tube, and there is a slight distance between two adjacent zinc alloy wires .

[0036] Further, the diameter of each zinc alloy wire is 0.05-0.2 mm.

[0037] Further, the flexible fully degradable zinc alloy nerve guide has a length of 5-200 mm, an outer diameter of 1.0-10.0 mm, and a tube wall thickness of 0.1-0.4 mm.

[0038] Further, the gap is 0.005-0.20mm.

[0039] Further, each row of zinc alloy wires forms an angle of 30-60 degrees with the tube axis of the round tube.

[0040] The preparation method of the bendable fully degradable zinc alloy nerve guide includes...

Embodiment 2

[0061] This embodiment relates to a bendable fully degradable zinc alloy nerve guide for nerve defect repair, its structure is as follows figure 1 As shown, the length is 200mm, the wall thickness is 0.40mm, and the outer diameter is 10mm. The nerve guide is braided by filaments with a diameter of 0.2 mm, the distance between two adjacent rows of filaments in the same direction is 0.20 mm, and the braiding angle between each row of filaments and the tube axis is 45 degrees.

[0062] This embodiment relates to the aforementioned method for preparing a degradable zinc alloy nerve guide for repairing nerve defects, and the shown method includes the following steps:

[0063] Step 1, extruding the initial Zn-Li-Fe ternary zinc alloy blank with an outer diameter of 30 mm and a length of 20 mm at a temperature of 230° C. to obtain a zinc alloy thick wire of Φ3 mm;

[0064] Step 2, after drawing the Φ3mm zinc alloy thick wire through multiple passes, a zinc alloy wire with a diameter...

Embodiment 3

[0069] This embodiment relates to a bendable fully degradable zinc alloy nerve guide for nerve defect repair, its structure is as follows figure 1 As shown, the length is 10mm, the wall thickness is 0.16mm, and the outer diameter is 2mm. The nerve guide is braided by filaments with a diameter of 0.10 mm, the distance between two adjacent rows of filaments in the same direction is 0.10 mm, and the braiding angle between each row of filaments and the tube axis is 60 degrees.

[0070] This embodiment relates to the aforementioned method for preparing a degradable zinc alloy nerve guide for repairing nerve defects, and the shown method includes the following steps:

[0071] Step 1, extruding a Zn-Li binary zinc alloy initial billet with an outer diameter of 25mm and a length of 25mm at a temperature of 240°C to obtain a zinc alloy thick wire of Φ2mm;

[0072] Step 2, drawing the Φ2mm zinc alloy thick wire through multiple passes to obtain a thin wire with a diameter of 0.10mm;

...

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Abstract

The invention provides a preparation method of a bendable fully-degradable zinc alloy nerve conduit. The preparation method comprises the following steps: step 1, extruding a zinc alloy initial blankby virtue of a mold to obtain a zinc alloy wire rough material; step 2, performing multi-pass cold drawing for the zinc alloy rough wire material obtained in step 1, and obtaining a final zinc alloy wire of the needed size; step 3, annealing the zinc alloy wire obtained in step 2; step 4, polishing the zinc alloy wire obtained in step 3; and step 5, alternately weaving the zinc alloy wire obtainedin step 4, and forming the bendable fully-degradable zinc alloy nerve conduit. The preparation method is simple in process, the zinc alloy is low in melting point, un-combustible, and easy to smelt,the zinc alloy wire can be obtained by directly performing the multi-pass cold drawing for the extruded rough wire without the heat treatment; and the woven degradable zinc alloy nerve conduit for repairing nerve deficiency is uniform and controllable in wall thickness and bendable.

Description

technical field [0001] The invention relates to a preparation method of a bendable fully degradable zinc alloy nerve guide, belonging to the technical field of biological material processing. Background technique [0002] Autologous tissues (such as nerves, blood vessels, acellular matrix, etc.) are often used clinically as materials for repairing peripheral nerve defects. However, the source of autologous tissues is limited and will cause permanent damage to the donor site. Bridging and repairing nerve defects through catheter-based tissue-engineered artificial nerves is the most promising therapeutic approach. At present, the catheters used in the repair of nerve defects are mainly concentrated in high molecular polymers and natural biomaterials (such as collagen, etc.). Although these materials have excellent biocompatibility, their degradation products are likely to cause inflammation in the surrounding tissues and collapse of the tube wall. The permeability of the tube...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/50A61L27/54A61L27/56A61L27/58B23P15/00
CPCA61L27/047A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/404B23P15/00
Inventor 黄华袁广银
Owner SHANGHAI JIAOTONG UNIV
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