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Mesenchymal stem cell protection liquid and application thereof

A technology of mesenchymal stem cells and protective solution, which is applied in the field of mesenchymal stem cell protective solution, can solve the problems of decreased activity and affect the treatment effect, and achieve the effects of improving vitality, reducing bacterial infection rate, and slowing down metabolism

Inactive Publication Date: 2018-03-09
BEIJING ZHEN HUIKANG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, commonly used clinical preservation solutions include 0.9% sodium chloride injection, 5% glucose injection, 1% human serum albumin solution, etc., but the activity of MSCs in these preservation solutions will decrease, which will affect the clinical therapeutic effect

Method used

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  • Mesenchymal stem cell protection liquid and application thereof
  • Mesenchymal stem cell protection liquid and application thereof
  • Mesenchymal stem cell protection liquid and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A mesenchymal stem cell protection solution, which is composed of 0.2 parts of AB type umbilical cord blood plasma, 8 parts of heme protein, 4 parts of myoglobin, 5 parts of HEPES and 500 parts of aqueous solution.

Embodiment 2

[0032] A mesenchymal stem cell protection solution, which is composed of 0.5 parts of AB type umbilical cord blood plasma, 11 parts of heme protein, 7 parts of myoglobin, 7 parts of HEPES and 1000 parts of aqueous solution.

Embodiment 3

[0034] A mesenchymal stem cell protection solution, which is composed of 1 part of AB type umbilical cord blood plasma, 15 parts of heme protein, 8 parts of myoglobin, 10 parts of HEPES and 1500 parts of aqueous solution.

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PUM

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Abstract

The invention provides mesenchymal stem cell protection liquid and application thereof. The protection liquid comprises, by weight, 0.2-1 part of AB-type umbilical cord blood plasma, 8-15 parts of hemoprotein, 4-8 parts of myohemoglobin, 5-10 parts of HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) and 500-1500 parts of water solutions. The mesenchymal stem cell protection liquid has the advantages that rich nutrition is provided for mesenchymal stem cells, survival rate is maintained, and storage time is prolonged.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a mesenchymal stem cell protection solution and its application. Background technique [0002] Mesenchymal stem cells (MSCs) are a type of pluripotent stem cells belonging to the mesoderm, which have strong proliferation ability and multi-directional differentiation potential. MSCs are distributed in bone marrow, liver, muscle, brain, skin and other tissues and organs. MSCs can not only differentiate into mesoderm cells such as hematopoietic cells, bone, cartilage, fat, and muscle under the internal and external environment, but also can differentiate into endoderm and ectoderm cells in a specific environment. Renewal, low immunogenicity and immunoregulatory inhibitory effect have very broad application prospects in the fields of tissue engineering, organ transplantation and treatment of immune-mediated diseases. [0003] Due to their strong ability to proliferate and differentiate,...

Claims

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0226
Inventor 曹毓琳刘俊江时兆田白志惠王俊王沾
Owner BEIJING ZHEN HUIKANG BIOLOGICAL TECH CO LTD
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