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Benzoyl hydrazine derivative P and synthesis and application thereof

A technology of benzoyl hydrazide and derivatives is applied in the fields of benzoyl hydrazide derivative P and its synthesis and application, and achieves the effects of high yield, good selectivity and low cost

Inactive Publication Date: 2018-03-06
HAINAN MEDICAL COLLEGE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fluorescent probes based on benzoyl hydrazide derivatives have been applied to the detection of mercury ions, lead ions, iron ions, chromium ions, and copper ions, but they are rarely used in the detection of aluminum ions and magnesium ions. It has not been reported that the needle can simultaneously realize the detection of the two ions under different pH conditions

Method used

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  • Benzoyl hydrazine derivative P and synthesis and application thereof
  • Benzoyl hydrazine derivative P and synthesis and application thereof
  • Benzoyl hydrazine derivative P and synthesis and application thereof

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Embodiment

[0022] Benzohydrazide derivative P is a compound represented by formula 1.

[0023] The preparation of benzohydrazine derivative P (see figure 1 ): Put 1mmol of ethyl o-hydroxybenzoate and 5mmol of hydrazine hydrate in 30ml of absolute ethanol, heat and reflux at 75-80°C for 4h, cool to room temperature, precipitate the solid and filter, wash the solid with absolute ethanol, and dry the obtained intermediate The bulk compound was used directly in the next step. The intermediate is reacted with o-hydroxynaphthaldehyde at a molar ratio of 1:1-1.2 in absolute ethanol at 75-80°C for 4 hours, and after cooling, the precipitated solid is suction-filtered, washed successively with a large amount of water and absolute ethanol, and dried to obtain Pale yellow solid pure product P, yield 85% (see figure 2 and image 3 ).

[0024] From figure 2 Molecular ion peaks and image 3 The chemical shift of H in can be used to know the generation of benzoylhydrazide derivative P.

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Abstract

The invention relates to detection of a fluorescence method on metal ions, and particularly relates to a benzoyl hydrazine derivative P which identifies and detects two different metal ions Mg<2+> andAl<3+> separately in different pH conditions. The structural formula of the benzoyl hydrazine derivative P is as shown in a formula (1). The preparation method of the benzoyl hydrazine derivative P comprises the following steps: firstly, carrying out hydrazinolysis on ethyl salicylate; carrying out a reaction with o-hydroxy naphthaldehyde at a molar ratio of 1 to 1 for 4 hours at 80 DEG C in anhydrous ethanol; cooling the mixture and separating out a solid and carrying out suction filtration; washing the mixture with a lot of water and anhydrous ethanol successively; and drying the solid to obtain a light yellow solid pure product P. The benzoyl hydrazine derivative P can be used for detecting Mg<2+> and Al<3+> separately in different pH conditions as a fluorescent probe. The benzoyl hydrazine derivative P is obtained by means of an effective synthetic means and shows relatively good selectivity on the metal ions Mg<2+> and Al<3+> separately. On a basis of an optimized experimental condition, the metal ions Mg<2+> and Al<3+> can be detected separately. The formula is as show in the description.

Description

technical field [0001] The invention relates to the detection of fluorescent probes, in particular to a benzohydrazide derivative P and its synthesis and application. Background technique [0002] Among the reported fluorescent molecular probes, most of them are a kind of probe to realize the detection of specific target substances. [1-3] . It has also been reported that the same probe uses different mechanisms to detect different metal ions [4] . However, it is rare to report that the same probe can detect different metal ions under different pH conditions. [0003] Benzohydrazide derivatives have excellent optical properties and are easy to synthesize, and have been widely used in metal ion fluorescent probes. Fluorescent probes based on benzoyl hydrazide derivatives have been applied to the detection of mercury ions, lead ions, iron ions, chromium ions, and copper ions, but they are rarely used in the detection of aluminum ions and magnesium ions. It has not been rep...

Claims

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Application Information

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IPC IPC(8): C07C249/16C07C251/86G01N21/64
CPCC07C249/16C07C251/86G01N21/643
Inventor 张军于春伟袁勇
Owner HAINAN MEDICAL COLLEGE
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