A compound DICTYOPTERISINF and applications thereof in preparation of anti-tumor medicines

An anti-tumor drug and technology for anti-tumor effect, applied in the field of medicine, can solve the problem of unreported anti-tumor activity

Active Publication Date: 2018-03-02
HUNAN STEROL PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reticopterin F is a new compound, and its antitumor activity has not been reported

Method used

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  • A compound DICTYOPTERISINF and applications thereof in preparation of anti-tumor medicines
  • A compound DICTYOPTERISINF and applications thereof in preparation of anti-tumor medicines
  • A compound DICTYOPTERISINF and applications thereof in preparation of anti-tumor medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation of described pterosin F

[0026] 1. Preparation of Reticula wavy extract extract

[0027] (1) Preparation of extract

[0028] 1.8 kg (wet weight) of frozen D. undulata (collected from the coast of Zhanjiang, Guangdong) were extracted three times by percolation with 5L 95% ethanol, each percolation for 2 days, and the extracts were combined;

[0029] (2) Preparation of extract extract

[0030] Concentrate the above extract under reduced pressure at a temperature of ≤45°C to recover ethanol to obtain 174.5 g of crude extract;

[0031] 2. Separation and purification

[0032] 1) Disperse the above crude extract in 2L of water to form a suspension, extract the suspension with ether (1.5L) four times, and concentrate the obtained extract under reduced pressure to obtain ether extract (54.3g);

[0033] 2) The diethyl ether extract was subjected to silica gel column chromatography, followed by petroleum ether / acetone and dichloromethanol / methan...

Embodiment 2

[0047] Embodiment 2: The in vitro antitumor activity test of the reticectin F

[0048] Cell lines: human acute promyelocytic leukemia cells (HL-60) and human lung cancer cells (A-549).

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PUM

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Abstract

The invention relates to the technical field of medicines, and relates to a novel natural medicine having anti-tumor functions and extracted and separated from dictyopteris undulata Holmes in China. The medicine is a steroid compound that is dictyopterisin F. In-vitro anti-tumor activity tests prove that IC50 values of the compound for human acute promyelocytic leukemia cells (HL-60) and human lung cancer cells (A-549) are 2.45 [mu]M and 2.85 [mu]M respectively, and therefore the compound can be used for preparing anti-tumor medicines, can be prepared into anti-tumor medicine compositions withother medicines, and can be prepared into injections, tablets, pills, capsules, solutions, suspensions, emulsions, and other dosage forms with pharmaceutically acceptable auxiliary materials, and administration routes of the compound can be oral administration, intravenous administration, intramuscular administration or percutaneous administration.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new natural medicine with anti-tumor effect extracted and separated from Chinese Dictyopteris undulata Holmes. The medicine is a new steroidal compound dictyopterisin F (dictyopterisin F). Background technique [0002] With the progress of society, the resulting increasing work pressure and the deteriorating global environment, the incidence of malignant tumors is increasing year by year, and malignant tumors have become one of the major diseases that endanger human health. According to the latest data released by the World Health Organization (WHO), 8.8 million people die from cancer every year in the world, accounting for nearly one-sixth of the total number of deaths in the world every year. There are more than 14 million new cancer cases every year, and this number is expected to increase to more than 21 million by 2030. Cancer will surpass cardiovascular disease and becom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00A61K31/575A61P35/00A61P35/02
CPCC07J9/00
Inventor 毛水春冯美堂蔡浙飞郭跃伟
Owner HUNAN STEROL PHARM TECH CO LTD
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