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Method for extracting curcuma oil and total curcumin in Curcuma longa as well as applications thereof

An extraction method and technology of turmeric oil, which is applied in the field of plant component extraction and separation, can solve the problems of complicated process, difficult control, high temperature and pH value requirements, and achieve the effects of simple extraction method, improved production efficiency, and easy operation

Inactive Publication Date: 2018-02-23
YAAN TAISHI BIOLOGICAL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the enzymatic method has high requirements on temperature and pH value, is difficult to control, and the process is complicated; the alkaline water extraction method can solve the problem that the turmeric extract is not easy to dry, but the curcumin is damaged greatly under alkaline adjustment, resulting in low yield and Does not collect turmeric oil efficiently

Method used

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  • Method for extracting curcuma oil and total curcumin in Curcuma longa as well as applications thereof
  • Method for extracting curcuma oil and total curcumin in Curcuma longa as well as applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Using turmeric as raw material, reflux extraction with acetone at 60°C for 2 hours, and then concentrate the extract at 65°C to obtain turmeric extract. Wherein, the solid-liquid ratio of turmeric and acetone is 1kg: 5L.

[0041] Mix methanol and water at a volume ratio of 40:60, and then use it to dissolve the above-mentioned turmeric extract to obtain a column sample. Among them, the volume ratio of methanol to turmeric extract is 3:1.

[0042]80-mesh neutral alumina particles are used as fillers to fill the chromatographic column, the upper column sample is passed through the neutral chlorine oxide chromatographic column, the unadsorbed effluent is collected, and the solvent is removed to obtain turmeric oil.

[0043] Use the alkane-ester mixture as the eluent to carry out gradient elution on the neutral chlorine oxide chromatography column. During the elution process, the volume ratio of alkane to ester increases from 1:0.5 to 1:4, and the elution flow rate is 1BV...

Embodiment 2

[0046] Use turmeric as raw material, after drying and grinding, extract three times with the mixture of isopropanol and water under the condition of 80°C, each time for 1.5h, combine the extracts obtained from the three extractions respectively, and then extract them at 75°C Concentrate the extract under conditions to obtain turmeric extract. Wherein, the volume ratio of isopropanol and water is 1:1, and the solid-liquid ratio of turmeric and the above-mentioned mixture of isopropanol and water is 1kg:8L.

[0047] Mix isopropanol and water at a volume ratio of 60:40, and then use it to dissolve the above-mentioned turmeric extract to obtain a column sample. Among them, the volume ratio of isopropanol to turmeric extract is 6:1. The column sample was filtered to obtain a filtrate.

[0048] 150-mesh neutral alumina particles are used as fillers to fill the chromatographic column, the upper column sample is passed through the neutral chlorine oxide chromatographic column, the u...

Embodiment 3

[0052] Use turmeric as raw material, after drying and grinding, under the condition of 65°C, use the mixture of methanol and water to reflux extract twice, each time for 2 hours, combine the extracts obtained from the two extractions respectively, and then extract them under the condition of 65°C Concentrate the extract to obtain turmeric extract. Wherein, the volume ratio of methanol and water is 4:1, and the solid-liquid ratio of turmeric and the above-mentioned mixture of methanol and water is 1kg:6L.

[0053] Mix ethanol and water at a volume ratio of 45:55, and then use it to dissolve the above-mentioned turmeric extract to obtain a column sample. Among them, the volume ratio of ethanol to turmeric extract is 4:1. The column sample was filtered to obtain a filtrate.

[0054] 120-mesh neutral alumina particles are used as fillers to fill the chromatographic column, the upper column sample is passed through the neutral chlorine oxide chromatographic column, the unadsorbed...

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Abstract

The invention relates to a method for extracting curcuma oil and total curcumin in Curcuma longa, and belongs to the field of plant component extraction and separation technology. The extraction method comprises the following steps: a first extraction solvent is used for extracting Curcuma longa, a solvent in the extract is removed, and an extract of Curcuma longa is obtained. The extract of Curcuma longa is dissolved, the extract passes a neutral aluminum oxide chromatography column, effluent is collected, and curcuma oil is obtained. Gradient elution is carried out with a neutral aluminum oxide chromatography column, elution components are collected, and the total curcumin is obtained. A first extraction solvent is a first organic solvent or a mixture of the first organic solvent and water. The first organic solvent comprises low carbon alcohol whose carbon atom number does not exceed 5, ethyl acetate and acetone. The extraction method is simple and easy to operate, time consuming isshort, utilization rate of raw materials is high, and the method is good for industrial production. The curcuma oil extracted by the method has pale yellow and cleared color, and good quality, and purity of extracted curcumin is high. The curcuma oil and the total curcumin can be used as effective components for foodstuff or medicines.

Description

technical field [0001] The invention relates to the technical field of extraction and separation of plant components, and in particular to an extraction method and application of turmeric oil and total curcumin in turmeric. Background technique [0002] Turmeric (Latin scientific name: Curcuma longa L.) is also known as turmeric, Baodingxiang, millet, and yellow ginger. It is a perennial herb that likes warm and humid climates. It is mainly distributed in Sichuan, Yunnan, Guangdong, Guangxi, Fujian and Taiwan in my country, and it is mainly distributed in Southeast Asia such as India and Indonesia abroad. The main components in turmeric are turmeric oil and curcumin, and curcumin mainly includes curcumin, demethoxy curcumin and bisdemethoxy curcumin. [0003] The total content of turmeric oil in turmeric rhizome is about 1.5%-3.5%, mainly containing curcumone, zingiberene, borneol, etc. Turmeric oil is often used in food spices and pigments. In traditional Chinese medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066C07C49/255C07C49/248C07C45/78C07C45/79A23L5/43A23L27/10A61P3/06A61P35/00A61P29/00A61P1/16A61P39/06A61P31/06
CPCA23L5/43A23L27/10A23V2002/00A61K36/9066A61K2236/333A61K2236/55C07C45/78C07C45/79A23V2200/04A23V2250/2112A23V2300/14C07C49/255C07C49/248
Inventor 梁林辉郭军伟杨军李海媚宋进博陈彬
Owner YAAN TAISHI BIOLOGICAL SCI & TECH CO LTD
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